Inflammatory mediators and NSAID effects

Spleen-dependent role of cyclooxygenase-1 in the physiological manifestations of severity in systemic inflammation

This study shows that COX-1 in the spleen mediates systemic inflammation severity through PGE2 and PGD2, as SC-560's effect on LPS-induced symptoms is lost after splenectomy.

Prostaglandin E2 facilitates reciprocal crosstalk between intestinal smooth muscle tissue and epithelium in tumor development

The paper identifies Prostaglandin E2 as a key mediator of crosstalk between intestinal smooth muscle tissue and epithelium in tumor development, showing reciprocal effects on both cell types.

OKN4395, a first-in-class EP2/EP4/DP1 triple antagonist reprograms prostanoid-driven immunosuppression to restore antitumor immunity

OKN4395, a triple EP2/EP4/DP1 antagonist, restores antitumor immunity by reversing prostanoid-driven immunosuppression and synergizes with anti-PD1 therapy.

Concomitant suppression of COX-1 and COX-2 is insufficient to induce enteropathy associated with chronic NSAID use

The paper shows that suppressing both COX-1 and COX-2 does not cause intestinal injury in mice unless combined with specific NSAIDs, and that gut microbiome changes amplify NSAID-induced enteropathy.

Mammalian Neuraminidase-1 is a Critical Target of Thromboxane Induced T-Cell Immunosuppression

This paper shows that aspirin and celecoxib inhibit TXA2-induced NEU1 activity and ARHGEF1 expression, explaining their similar clinical efficacy in colorectal cancer.

Indomethacin exerts both cyclooxygenase inhibition-dependent and independent mechanisms to enhance chemo-immunotherapy in mice

This study shows indomethacin enhances chemo-immunotherapy in mice through both COX-dependent and independent mechanisms, including RAS inhibition.

Phagocytosis is differentially regulated by LPS in M1- and M2-like macrophages via PGE2 formation and EP4 signaling

This study shows that LPS differentially affects phagocytosis in M1- and M2-like macrophages via PGE2 and EP4 signaling, with NSAID inhibition increasing phagocytosis in M1-like macrophages.

Metabolomic Response to Non-Steroidal Anti-Inflammatory Drugs

This study compares the metabolomic effects of naproxen and celecoxib in humans and mice, finding that naproxen reduces tryptophan levels independently of Cox-2 inhibition.

Spatiotemporal Characterization of Cyclooxygenase Pathway Enzymes During Vertebrate Embryonic Development

The paper characterizes the spatiotemporal expression of COX pathway enzymes during avian embryonic development and suggests potential non-canonical roles in early neural development.

Cyclooxygenase-2 disruption predisposes to heart failure with preserved ejection fraction

This study shows that COX-2 deletion or inhibition leads to heart failure with preserved ejection fraction in zebrafish, mice, and humans.

Disruption of the PGE2 synthesis / response pathway restrains atherogenesis in programmed cell death-1 (Pd-1) deficient hyperlipidemic mice

This study shows that disrupting the PGE2 synthesis or response pathway reduces atherogenesis in PD-1 deficient hyperlipidemic mice through different immune mechanisms.

Amino-alcohol Bio-conjugate of Naproxen Exhibits Anti-inflammatory Activity through NF-κB Signaling Pathway

The paper investigates NBC-2, a naproxen bio-conjugate with amino alcohol, showing enhanced anti-inflammatory effects by inhibiting NF-κB signaling and reducing pro-inflammatory proteins in macrophages.