Trace Elements in Health

Copper modulates iron-dependent survival through distinct TORC1 and AMPK signaling pathways

The paper shows copper and iron regulate cellular survival through distinct TORC1 and AMPK pathways in yeast under nutrient stress.

Multiomics Approach to Regionally Profile Zinc-Driven Host-Gut Microbiome Interactions in the Intestinal Tract

This study uses a multiomics approach to examine how zinc deficiency affects host-gut microbiome interactions in mice, revealing region-specific changes in metabolism, immunity, and microbial diversity.

Distinct signaling mechanisms and proteome phenotypes are elicited by compartment-specific genetic defects of copper homeostasis

The paper compares the effects of copper deficiency in CTR1- and COX17-deficient cells using multiomics approaches, revealing distinct signaling mechanisms and proteome responses.

THE EVOLUTIONARY HISTORY OF METALLOTHIONEINS IN HORSESHOE CRABS, SCORPIONS, SPIDERS AND OTHER CHELICERATE SPECIES.

This study identifies and classifies over 400 metallothioneins (MTs) in chelicerates, revealing three types with distinct structural and evolutionary features.

Dynamic assessment of the allocation of copper to cytochrome c oxidase using size-exclusion chromatography (SEC) combined with inductively coupled plasma mass spectrometry (ICP-MS)

This study uses SEC-ICP-MS to assess copper allocation to cytochrome c oxidase and identifies key transporters involved in mitochondrial copper trafficking.

The copper chaperone ATOX1 exhibits differential protein-protein interactions and contributes to skeletal myoblast differentiation

The paper investigates ATOX1's protein-protein interactions during myoblast differentiation and shows its dynamic interactome contributes to skeletal myoblast differentiation.

Lysosomal Expansion Compartments Mediate Zinc and Copper Homeostasis in Caenorhabditis elegans

The paper shows that lysosomes in C. elegans expand to store zinc, copper, and manganese, with metal transporters localizing to both acidified and expansion compartments.

Conserved inter-domain interactions drive trans-Golgi network localisation and trafficking of homologous copper-ATPases

This study identifies conserved inter-domain interactions critical for TGN localization and copper trafficking in Cu-ATPases by analyzing chimeric proteins and evolutionary relationships.

Metabolic regulation of copper homeostasis governs the Sec61-dependent protein translocation process in Saccharomyces cerevisiae

This study shows that metabolic pathways regulate copper homeostasis and protein translocation in yeast, with amino acids and mitochondrial function playing key roles.

Systematic characterization of zinc in a series of breast cancer cell lines reveals significant changes in zinc homeostasis

This study measures zinc levels in breast cancer cell lines and finds differences in zinc homeostasis affecting proliferation and viability.

Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration

The paper investigates how neuronal cells adapt to copper deficiency by increasing protein synthesis through mTORC1 activation and reduced PERK signaling in multiple model systems.

Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings

The paper identifies SLC39A5 as a gene whose loss-of-function variants are associated with reduced type II diabetes risk and improved liver function in metabolic disorders.

Cysteine Rich Intestinal Protein 2 is a copper-Responsive regulator of skeletal muscle differentiation.

This study identifies mCrip2 as a copper-responsive regulator of skeletal muscle differentiation through functional and biochemical analyses in murine myoblasts.

Determination of metal ion transport rate of human ZIP4 using stable zinc isotopes

This paper determines the turnover number of human ZIP4 using stable zinc isotopes and ICP-MS, finding it ranges from 0.08 to 0.2 s-1.

Developmental regulation of zinc homeostasis in differentiating oligodendrocytes

The paper investigates zinc homeostasis changes during oligodendrocyte differentiation using zinc sensors and gene expression analysis, finding dynamic regulation of zinc levels and storage proteins.

The role of intestine in metabolic dysregulation in murine Wilson disease

This study investigates the role of the intestine in metabolic dysregulation in murine Wilson disease by analyzing gut microbiota and lipidome in mouse models.

Wilson disease: intersecting DNA methylation and histone acetylation regulation of gene expression in a mouse model of hepatic copper accumulation

This study investigates how DNA methylation and histone acetylation changes in a mouse model of Wilson disease are influenced by diet and copper chelation, revealing their role in regulating gene expression in metabolic pathways.

Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content

This study shows that Golgi-dependent copper homeostasis, mediated by ATP7 and COG, is essential for maintaining mitochondrial function and synaptic integrity in neurons.

Natural variation in the sequestosome-related gene, sqst-5, underlies zinc homeostasis in Caenorhabditis elegans

The paper identifies a gene, sqst-5, associated with zinc resistance in C. elegans by analyzing genetic variation between strains with different zinc responses.

Zinc oxide nanoparticles modulate the gene expression of ZnT1 and ZIP8 to manipulate zinc homeostasis and stress-induced cytotoxicity in human neuroblastoma SH-SY5Y cells

This study shows that low concentrations of ZnO-NP elevate [Zn2+]c, modulate ZnT1 and ZIP8, and reduce 6-OHDA-induced cytotoxicity in SH-SY5Y cells.

Copper Induces Zebrafish Central Neural System Myelin Defects: the Regulatory Mechanisms in Wnt/Notch-hoxb5b Signaling and Underlying DNA Methylation

This study identifies copper-induced myelin defects in zebrafish via disruption of Wnt/Notch-hoxb5b signaling and DNA methylation of fam168b/pou3f1 genes.

Brain-derived neurotrophic factor and TrkB levels in mice that lack vesicular zinc: Effects of age and sex

This study measures BDNF and TrkB levels in ZnT3 knockout mice across ages and sexes, finding no difference in protein levels but sex-specific mRNA expression changes.

Effects of enriched housing on the neuronal morphology of mice that lack zinc transporter 3 (ZnT3) and vesicular zinc

This study examines the effects of environmental enrichment on neuronal morphology in ZnT3 knockout mice, finding no modulation of enrichment effects by ZnT3 absence.

The pharmacological perturbation of brain zinc impairs BDNF-related signalling and the cognitive performances of young mice

This study shows that reducing brain zinc levels with clioquinol impairs memory and BDNF-related signaling in young mice.