Trace Elements in Health

Functional validation and characterization of Slc39a8 genotype effects on ethanol consumption and related phenotypes

This study investigates the effects of Slc39a8 genotype on ethanol consumption and related behaviors in mice, finding reduced alcohol intake in heterozygous knockout mice without changes in locomotion or affective behaviors.

Metallothionein loss in cancer cells contributes to increased mutations through defective DNA repair and metabolic imbalance

This study shows that loss of metallothionein (MT) in cancer cells increases mutations by impairing DNA repair and causing metabolic imbalance.

Hydrogen sulfide dynamically upregulates copper uptake and localization

This study shows hydrogen sulfide increases copper uptake and localization in cells, with copper primarily in the Cu2+ state, using the ZNT1 transporter for import and ATP7A for export.

Disrupted Mitochondrial Copper Homeostasis Promotes Ferroptotic Stress, Senescence and MASLD Progression

This study shows that mitochondrial copper deficiency drives MASLD by causing ferroptosis, senescence, and fibrosis, and that restoring copper homeostasis can alleviate disease.

A Dual-Function Guanidinium Scaffold that Couples Copper Sequestration with Redox Protection in Wilson disease

This paper introduces Gua-Cu-3, a dual-function molecule that sequesters copper and reduces oxidative stress in Wilson disease models, outperforming existing treatments.

Mitochondrial degradation of metallothionein enables local zinc mobilization during zinc limitation

The paper identifies a mitochondrial degradation pathway for metallothionein that releases zinc during zinc limitation, maintaining metabolic homeostasis.

Metal homeostasis is remodeled in response to different quiescence triggers

The paper investigates metal homeostasis changes in quiescent cells induced by different triggers and finds trigger-specific remodeling of metal pools and associated gene expression.

Deficiency of the membrane androgen receptor ZIP9 alters brain zinc distribution, reproductive endocrinology, and female fertility

This study shows that ZIP9 deficiency in zebrafish disrupts zinc distribution, reproductive endocrinology, and female fertility.

Zinc excess promotes lysosome remodeling by activating HLH-30/TFEB through the action of the high zinc sensor HIZR-1.

The paper identifies a zinc-regulated genetic pathway in C. elegans that activates lysosome remodeling through HIZR-1 and HLH-30/TFEB to enhance zinc detoxification.

Cellular Senescence Drives Zinc Accumulation and Transporter Dysregulation in Intestinal Epithelial Cells

The paper investigates zinc homeostasis in senescent intestinal epithelial cells, finding increased zinc levels and transporter dysregulation, with chelation reducing senescence markers.

Context-dependent ATP7 Interactions with Parkinson's Disease-associated Genes Modulate Copper Homeostasis Phenotypes

The paper investigates context-dependent interactions between ATP7 and Parkinson's disease-associated genes in Drosophila, revealing sex-specific effects on copper homeostasis and neurodegeneration.

A First-In-Class Broad Spectrum Inhibitor of Copper Exporting P1B-type ATPases

This paper identifies MKV3 as the first small-molecule inhibitor of Cu+-transporting P1B-type ATPases, showing broad activity across species and defining a conserved Cu+ entry pocket for drug development.

NON-REDUNDANT ROLES OF COPPER TRANSPORTERS ATP7A AND ATP7B IN NORADRENERGIC SIGNALING

This study investigates the distinct roles of ATP7A and ATP7B in noradrenergic signaling, showing they have non-redundant functions in neuronal copper homeostasis and metabolic regulation.

A Closed Computational - Experimental Loop Identifies Metabolic Collapse at the Root of Macrophage Dysfunction due to Zinc Dyshomeostasis

This study identifies metabolic collapse due to zinc dyshomeostasis in macrophages, showing succinate and kynurenic acid can restore immune function.

Alcohol Use Disorder Affects Brain Metals

This study measures trace metal levels in brain regions of individuals with and without alcohol use disorder, finding dysregulated iron and other metals, particularly in females.

Cisplatin and Copper Induce Distinct Endocytic Pathways of Copper Transporter-1 and Elicits Unique Response on Copper Homeostasis Proteins

The paper shows that cisplatin and copper use distinct endocytic pathways via CTR1, leading to different effects on lysosomal acidity and copper homeostasis proteins.

Discovery of a Selective Inhibitor of ZIP14 with Therapeutic Potential for Cancer-associated Cachexia

This paper identifies PPTD, the first selective ZIP14 inhibitor, showing it reverses ZIP14-driven cytotoxicity and ameliorates cancer cachexia in mice.

Quantitative Prevalence, Chemical Speciation, and ECM-Embedded Networks of Biogenic Silicon in Animal Tissues Revealed by Refined Analytical Methods

The paper refines analytical methods to quantify, identify, and visualize biogenic silicon in animal tissues, revealing its abundance and ECM-embedded networks in mice and humans.

Changes in Urinary Proteome Post-Translational Modifications Following Short-Term Intake of Specific Magnesium, Calcium, Zinc, and Iron Supplements in Rats

This study examines changes in urinary proteome post-translational modifications in rats after short-term mineral supplementation, finding age-dependent responses and associations with mineral metabolism.

Repurposing Melatonin in dual-mode for Wilson disease therapy as a Copper Chelator and an antioxidant agent

This paper evaluates melatonin as a dual-function therapeutic for Wilson disease, showing it reduces copper toxicity and oxidative stress in vitro and in vivo.

Structures and zinc ion transport pathways of the human SLC39A family of metal transporters

This study uses AlphaFold3 to predict 3D structures of all 14 human ZIP family zinc transporters, revealing structural features and zinc-binding motifs that explain their transport mechanisms.

Novel Role of Copper Transporter CTR1 and Therapeutic Potential of Copper Chelators in Retinal Ischemia-Reperfusion Injury

This study shows that CTR1 contributes to retinal ischemia-reperfusion injury by promoting oxidative stress and inflammation, and that copper chelators like TTM can mitigate these effects.

Epithelium intrinsic zinc sensor controls immune homeostasis with gut microbes via regulation of Tuft cell lineage

This study shows that zinc sensing via MTF1 in intestinal epithelial cells regulates Tuft cell lineage and immune homeostasis with gut microbes.

Excessive zinc reduces histone acetylation in mouse cardiomyocytes by downregulating acetyltransferases

This study shows excessive zinc reduces histone acetylation in mouse cardiomyocytes by downregulating acetyltransferases, not deacetylases, and links this to reduced Bmp4 expression.

Endothelial Cu Uptake Transporter CTR1 Senses Disturbed Flow to Promote Atherosclerosis through Cuproptosis

This study shows that endothelial CTR1 senses disturbed flow by increasing mitochondrial copper, leading to cuproptosis and atherosclerosis, and identifies a therapeutic target.

Role of copper during microglial inflammation

The paper investigates how copper levels affect microglial inflammation, finding that both excess and deficiency disrupt immune responses to LPS.

Glial swip-10 expression controls systemic mitochondrial function, oxidative stress, and neuronal viability via copper ion homeostasis

This paper identifies swip-10's role in systemic copper homeostasis in C. elegans, linking it to mitochondrial function, oxidative stress, and neurodegeneration.

Cellular zinc status alters chromatin accessibility and binding of transcription factor TP53 to genomic sites

The paper shows that changes in labile zinc levels affect chromatin accessibility and TP53 binding to DNA.

Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn2+ uptake into the Golgi apparatus

The paper presents cryo-EM structures of human ZnT7, revealing its mechanism for Zn2+ uptake into the Golgi apparatus through conformational changes and histidine-rich loop interactions.

Copper imbalance linked to oxidative stress and cell death during Zika virus infection in human astrocytes

This study shows that ZIKV infection disrupts copper homeostasis in human astrocytes, leading to oxidative stress and cell death, and that copper chelation can reduce oxidative stress and improve cell viability.