Bacteriophages and microbial interactions

Virus {Psi}M2 enters a non-lytic lifecycle alternative to lysogeny during infection of Methanothermobacter marburgensis

This study shows that the virus {Psi}M2 can enter a non-lytic lifecycle alternative to lysogeny in Methanothermobacter marburgensis under suboptimal conditions, with genetic variability in viral populations.

Epidemiological model selection unravels the molecular processes of antiviral resistance from experimental phytoplankton-virus dynamics

The paper uses epidemiological models to identify molecular mechanisms of antiviral resistance in phytoplankton from experimental data.

A phage-encoded host transcription modulator, Htm, reprograms the transcriptome of ESBL Escherichia coli

This study identifies Htm, a phage-encoded protein that reprograms the transcriptome of ESBL-E. coli to support phage replication by altering gene expression and metabolic pathways.

Analysis of Phycodnaviridae Tetrapyrrole Enzymes: Subcellular Localization and Functional Divergence from Host Homologs

The paper analyzes Phycodnaviridae viral homologs of heme oxygenase-1 and Phycocyanobilin:Ferredoxin oxidoreductase to predict their subcellular localization and functional divergence from host enzymes.

Conserved mycobacteriophage protein uses structural mimicry to displace host initiation factors

The paper identifies a conserved viral protein module that displaces host RNA polymerase sigma factors to control transcription in mycobacteria.

Uncovering novel phage defense systems through genomic island analysis in Streptococcus thermophilus

This study identifies novel antiviral defense systems in Streptococcus thermophilus by analyzing genomic islands, revealing previously uncharacterized systems and highlighting their role as reservoirs of bacterial immunity.

Host Cellular Remodeling, Not Viral Transcriptional Inhibition, Drives Quorum Sensing Signal-Mediated Evasion of Viral Lysis in Gephyrocapsa huxleyi

The paper shows that HHQ enables Gephyrocapsa huxleyi to evade viral lysis by remodeling host processes, not by inhibiting viral transcription.

Genetic exchange drives relatedness of large linear and circular extrachromosomal elements of archaea

The paper identifies three new families of archaeal extrachromosomal elements and shows their relatedness is due to horizontal gene transfer, not common ancestry.

Evidence of active phage replication during vegetable fermentation and implications for the dynamics of bacterial communities

The paper investigates phage activity during vegetable fermentation and shows phages influence bacterial succession without disrupting fermentation stability.

Tracking gene flow in the gut microbiome reveals phage activation and host-range expansion in response to diet

The paper tracks gene flow in the gut microbiome, showing diet and community ecology influence phage activation and horizontal gene transfer.

Environment-dependent evolution drives divergent adaptive strategies balancing parasite costs and competitive benefits

The paper investigates how prophage costs and competitive benefits shape bacterial evolution in polymicrobial environments, finding environment-dependent adaptive strategies and trade-offs.

A bifunctional RNase H protein supports DNA replication and transcription in nucleus-forming Chimalliviridae phages

This study identifies Rhc as a multifunctional protein essential for DNA replication and transcription in nucleus-forming phages, revealing its role in resolving R-loops and coordinating gene expression.

A bacteriophage split DNA polymerase incorporates a sliding clamp-derived processivity subunit

This study identifies a unique DNA replication mechanism in the chimallivirus PhiKZ, where a sliding clamp-derived protein enhances polymerase activity through a transient interaction.

The bacterial antiphage protein Tiamat is an ATPase and DNase whose homologs are found across the tree of life

This study identifies Tiamat as an ATPase and DNase in bacteria and shows its homologs are widespread across eukaryotes, with some acquiring non-defense roles.

A novel virus lineage is abundant in metaviromes from Dehalococcoides-containing mixed cultures

The paper identifies a novel virus lineage, IME1, found in Dehalococcoides-containing cultures, characterized by features similar to filamentous bacterial viruses.

Site, Fertilization and Season Structure the Soil Microbiome and its Interactions with Bdellovibrio and Like Organisms Predators

The paper investigates how season and fertilization affect soil microbiome dynamics and interactions with Bdellovibrio-and-Like Organisms (BALOs) in agricultural fields.

Isolation and characterisation of Lytic Jumbo Klebsiella phage BMPCR_005026

The paper isolates and characterizes a new jumbo Klebsiella phage, BMCPR_005026, identifying it as a new species within the Alcyoneusvirus genus with limited host range.

RecBCD Prevents Bacterial Autoimmunity by Clearing Self-DNA Ends Produced During Replication Termination

The paper shows that RecBCD clears self-DNA ends during bacterial replication termination to prevent autoimmunity, similar to TREX1 and DBR1 in eukaryotes.

Virophage-like viruses replicate with a candidate phycodnavirus of C. parva

Two polinton-like viruses, Larry and Curly, replicated in C. parva cultures only with the Algavirales phycodnavirus CpV-BQ1, not with the Imitervirales virus CpV-BQ3, and they reduced BQ1 replication.

Genomic Characterization of 30 Lytic Klebsiella pneumoniae Bacteriophages

This study characterizes 30 lytic Klebsiella pneumoniae bacteriophages, finding diverse genomic structures and no virulence or antibiotic resistance genes, with potential as antimicrobial agents against carbapenem-resistant K. pneumoniae.

Capsule types driving carbapenem-resistant Klebsiella pneumoniae in Pakistan are largely absent from the phage literature

The paper identifies capsule types in carbapenem-resistant Klebsiella pneumoniae from Pakistan that lack corresponding phages, highlighting regional disparities in phage coverage.

A reference genome without a virus: cDNA reconstruction reveals the provenance and function of the MS2 phage sequence

The paper reconstructs the MS2 phage genome using cDNA and shows that the current NCBI reference genome does not produce infectious phage, highlighting the need to verify reference genome infectivity.

Anti-defense systems of viral communitie vary with genomic traits, host immunity and environmental stress

The paper investigates how viral anti-defense systems vary with genomic traits, host immunity, and environmental stress across microbial ecosystems.

Bacteriophage and Antibiotic Resistance Are Positively Associated across a Phylogenetically Diverse Set of Clinical Pseudomonas aeruginosa Isolates

The paper examines the association between phage and antibiotic resistance in Pseudomonas aeruginosa clinical isolates and finds a positive correlation between the two resistance phenotypes.

A microbiota-derived protease links phage susceptibility to host epithelial responses

This study identifies a bacterial protease that influences phage susceptibility and links it to host epithelial responses in ulcerative colitis.

Viral infection and virophage co-infection induce distinct remodeling of host lipidome

This study investigates how giant virus and virophage co-infection alter the host lipidome, finding distinct lipid remodeling patterns associated with each infection type.

CheckAMG: Accurate Identification of Auxiliary Viral Genes with Genome-Language Models

CheckAMG identifies auxiliary viral genes by combining annotation-based prediction with a genome-language model, improving accuracy and uncovering novel genes with no sequence similarity to references.

Cellular heterogeneity in the response of Burkholderia thailandensis to antibiotics and phages in synthetic spatial refuges

This study investigates how Burkholderia thailandensis responds to antibiotics and phages in spatial refuges, revealing distinct subpopulation behaviors and interactions.

Loss of restriction-modification methyltransferases drives persistence to fluoroquinolones in Pseudomonas aeruginosa

This study shows that loss of type I restriction-modification methyltransferases in Pseudomonas aeruginosa increases fluoroquinolone persistence through enhanced SOS response and slower growth.

Bloom-forming bacteria heavily invest in anti-phage defense

This study shows bloom-forming bacteria, like GSB-TRL01, invest heavily in anti-phage defense systems, which reduces lysis and allows blooms to persist.