Ion Channels and Receptors

This study shows that swimming motions in larval zebrafish trigger Ca2+ events in vascular endothelial cells through mechanical activation of Piezo1, independent of neural activity or blood flow.

The paper identifies a dominant-negative TRPV1 splice variant unique to catarrhine primates, which inhibits canonical TRPV1 function by preventing its membrane localization.

This study characterizes TRPM3 activation by chemical agonists and heat, revealing a shared mechanism involving intracellular domain rearrangements.

This study shows that mitochondria-ER contacts inhibit store-operated Ca²⁺ entry by trapping STIM1 through Ca²⁺ flickering and microdomain formation.

This study identifies DEGT-1 as a mechanosensory ion channel in C. elegans that modulates pharyngeal pumping by detecting proprioceptive feedback from organ movement.

The paper investigates the dynamic localization and activity-dependent behavior of STIM1 and STIM2 at ER-PM contacts in hippocampal neurons, revealing their heterogeneous dynamics and differential recruitment under different conditions.

The paper identifies bidirectional thermoreceptors in mice that respond to both cool and warm temperatures, revealing their role in encoding innocuous thermal sensations.

The paper shows that ER Ca2+ depletion in mouse neurons reduces DCV exocytosis by inhibiting L-type Ca2+ channels via a STIM1-dependent feedback loop, while not affecting SV exocytosis.

The paper reports the cryo-EM structure of TRPC1/5 heterotetramer, revealing structural features that differentiate it from TRPC5 homomers and provide insights into its functional properties.

The paper engineers hTRPV4 to create an ultrasound-sensitive actuator for sonogenetics, showing improved mechano-sensitivity and reduced sensitivity to other stimuli.

This study shows TRPM8 controls Golgi morphology by regulating Scd1 gene expression and lipid content via the androgen receptor.

The paper identifies and characterizes a conserved population of spinal cerebrospinal fluid contacting neurons in mice, revealing their sensory functions and receptor expression.

This study identifies TENM4 as an essential extracellular linker protein for mechanotransduction in mechanoreceptors, showing its role in touch sensitivity.

This study investigates magnetogenetic tools to regulate T cell activity, finding they enhance activation with antigen stimulation but deactivate cells without it.

This study uses electrophysiology and in silico modeling to propose binding sites and modes of action for four CRAC channel inhibitors.

The paper identifies a mitochondrial TRPV1 isoform, mitoTRPV1, which regulates intracellular Ca2+ and mitochondrial temperature without affecting respiration.

This study investigates how inflammatory mediators affect TRPM3 channel function in mouse sensory neurons and finds that IL-1β and TNF potentiate TRPM3 without changing its expression, while pharmacological blockade does not alleviate inflammatory pain in a specific model.

This paper shows that Piezo1 and Piezo2 channels are expressed in retinal ganglion cells and that their activation increases light-dependent neural activity and excitability, potentially linking to glaucoma progression.

The paper shows that the C. elegans PIEZO channel regulates pharyngeal movement by sensing food accumulation in the intestine.

This study identifies glucosidase II as a regulator of STIM1 activation dynamics by modulating Ca2+ binding affinity and influencing store-operated Ca2+ entry.

This study investigates osmosensing mechanisms in trabecular meshwork cells, identifying TRPV4 and Cl- channels as key players in volume regulation and calcium homeostasis under osmotic stress.

This study identifies glutamate as a co-agonist for acid-sensing ion channels (ASICs) that worsens ischemic brain damage, and presents a small molecule inhibitor that targets this interaction without affecting NMDARs.

This study identifies distinct temperature representations in the somatosensory thalamus of mice, showing differences in cellular encoding and cortical output targets.

This study identifies TMEM63B as a mammalian thirst receptor in the subfornical organ, showing it mediates osmotic and dehydration-induced thirst through ion channel activity.

This study shows TRESK channels regulate non-histaminergic itch by modulating sensory neuron excitability, and enhancing TRESK function reduces acute and chronic itch in mice.

This study shows that SHP-1 overexpression reduces capsaicin-induced mechanical allodynia in both male and female mice by dephosphorylating TRPV1 in DRG neurons.

This study shows that SARS-CoV-2's PLpro activates nociceptors to cause sneezing and pain by triggering TRPA1-dependent responses.

This study shows that silencing TRPV1-expressing fibers reduces colitis-induced visceral pain in rats by using QX-314 with TRPV1 activators or blockers.

This study identifies Krause corpuscles as vibrotactile sensors in the genitalia essential for normal sexual behavior in mice.

The paper shows that SOCE-mediated Ca2+ elevation drives membrane bleb formation in avian PGCs, essential for in vivo migration.