Congenital heart defects research

This study shows that oxytocin promotes epicardial cell activation and heart regeneration in both mammals and zebrafish by inducing proliferation, EMT, and migration through the TGF-β pathway.

This study shows that epicardial impairment in zebrafish leads to smaller ventricles due to defective cardiomyocyte growth, highlighting the role of FGF and VEGF signaling in cardiac morphogenesis.

This study shows that coupled proliferation of cardiac endothelial cells and cardiomyocytes is essential for heart growth and regeneration, mediated by VEGF-VEGFR2 signaling.

The paper shows that DICER1 activity is essential for mitral valve development but not tricuspid valve development, revealing miRNA-mediated gene regulation as a differential mechanism.

The paper identifies lineage regionalization defects in a mouse model of DiGeorge syndrome using vitamin B12 treatment and shows that SLUG+ cells are mislocalized and partially rescued by treatment.

The paper identifies fibroblast-like cell types as key drivers of heart regeneration in zebrafish using single-cell transcriptomics and lineage tracing.

This study identifies KMT2D-NOTCH signaling defects in HLHS coronary artery endothelial cells, showing impaired differentiation and proliferation due to suppressed NOTCH target genes.

This study shows that PKN2 deficiency causes prenatal congenital cardiomyopathy and impairs angiotensin II-induced cardiac hypertrophy in adult mice.

This study shows that HDAC3 in the epicardium promotes myocardial growth by regulating FGF9 and IGF2 through miR-322/miR-503 repression.

This study identifies GATA4/5/6 as conserved regulators of cardiac versus pharyngeal mesoderm fate by analyzing single-cell gene expression in zebrafish and Ciona.

This study shows that Apelin signaling-dependent endocardial protrusions are essential for cardiac trabeculation by modulating cardiomyocyte behavior through Neuregulin and Erk signaling.

The paper identifies enhancer elements that regulate epicardial gene expression during zebrafish heart regeneration by analyzing transcriptomes and chromatin accessibility.

This study shows ERp44 is essential for endocardial cushion development by regulating VEGFA secretion in myocardium, leading to congenital heart defects in mice.

The paper identifies heterogeneous pdgfrβ+ cells critical for coronary vessel development and heart regeneration in zebrafish.

The paper shows that coronary endothelial cells in mouse and human hearts initially show lineage-specific transcriptional differences but later become influenced by location, with adult cells becoming more homogeneous.

This study shows that inhibiting GSK-3β in cardiomyocytes promotes cardiac progenitor cell proliferation and improves cardiac function after myocardial infarction through paracrine signaling.

This study identifies a Tbx1-dependent multilineage primed population in the murine cardiopharyngeal mesoderm using single-cell RNA-sequencing and shows its role in cardiac and skeletal muscle development.

This study demonstrates that African spiny mice exhibit improved cardiac repair and tolerance to myocardial infarction compared to other mammals.

This study shows that spiny mice (Acomys) have better cardiac recovery after myocardial infarction compared to common lab mice, with less scarring and better function.

This study identifies sequential defects in cardiac lineage commitment and maturation in hypoplastic left heart syndrome using multi-omics approaches and iPSC modeling.

This study identifies a gene regulatory network involving Tbx5, RA, Hedgehog, and Wnt signaling that coordinates cardiopulmonary development.

This study shows direct RA signaling in cardiomyocytes protects against apoptosis after MI in mice by identifying Tgm2 and Ace1 as RA targets.

This study identifies a role for laminin in zebrafish heart development by showing that Lamb1a limits SHF addition to the atrium, preventing excessive growth and morphogenesis defects.

The paper identifies rare GATA6 variants linked to increased risk of bicuspid aortic valve in a large UK Biobank exome study.

This study identifies Prrx1b's role in directing pro-regenerative fibroblasts during zebrafish heart regeneration, reducing fibrosis and promoting tissue repair.

This study shows noncanonical Notch signaling has stage-specific roles in cardiac development, inhibiting early heart formation but promoting later growth.

This study shows that overexpressing Dach1 in endothelial cells extends coronary arteries and improves heart function after myocardial infarction in mice.