Neonatal and Maternal Infections

Glucose restriction reduces systemic, but not cardiac, inflammation during neonatal sepsis in preterm pigs

Monocyte microRNA signatures in late-onset neonatal sepsis

This study identifies monocyte-specific miRNA expression changes in neonatal late-onset sepsis and links them to clinical markers like NLR.

Microbial Crosstalk in the Neonatal Gut: Candida albicans Impacts Group B Streptococcus Pathogenicity

This study shows that Candida albicans increases Group B Streptococcus burden and pathogenicity in the neonatal gut, with fluconazole reducing extraintestinal GBS spread.

Serum proteomics in newborns reveals a multi-pathway molecular panel for neonatal sepsis, encompassing pathogen sensing, leukocyte recruitment, and endothelial injury.

This study identifies a 53-protein serum panel in newborns associated with three key biological processes in sepsis: pathogen sensing, immune activation, and endothelial injury.

Investigating laboratory capacity and whole genome sequencing practices to inform standardised protocols for bacterial genomic surveillance in Africa.

This study surveys genomic surveillance practices in African labs, finding sufficient capacity but highlighting needs for improved infrastructure and standardization.

Serial acquisition of virulence determinants and aminoglycoside resistance by the emerging Streptococcus agalactiae sequence type 1010 lineage

This paper analyzes the genomic characteristics of Streptococcus agalactiae ST1010 strains, showing they share virulence genes with CC17 and have a subclade with high-level gentamicin resistance.

Home is where the host is: Evolutionary history of geographic spread, host switching, and adaptive genomic signatures in two generalist Group B Streptococcus clonal groups

This study analyzes the evolutionary history and host adaptation of two GBS clonal groups, revealing host switching, regional AMR gene distribution differences, and biased sampling in multi-host pathogens.

Competitive advantage of hypervirulent Group B Streptococcus for neonatal colonization revealed by metagenomic analysis of gut microbiota

The paper identifies GBS CC17's competitive advantage over non-CC17 GBS in neonatal gut colonization through metagenomic analysis and in vitro experiments.

Reduced parenteral glucose supply in preterm neonatal infection ameliorates the pulmonary damage

This study shows that reducing glucose supply in preterm infants with infection reduces pulmonary damage and metabolic disturbances.

A neonatal rat sepsis score captures the time course and severity of disease in a clinically relevant rat peritonitis model.

This paper develops a neonatal rat sepsis model and scoring system to monitor disease severity and time course in a clinically relevant polymicrobial sepsis context.

A fungal pathobiont promotes Streptococcus agalactiae vaginal persistence and pathogenesis through physical and metabolic interactions

This study shows that Candida albicans supports Group B Streptococcus vaginal persistence and pathogenesis through physical and metabolic interactions.

RodA Promotes Intestinal Colonization by Group B Streptococcus

This study shows that RodA promotes Group B Streptococcus intestinal colonization by enhancing fitness under gastrointestinal stress and competitive interactions.

Maternal low-fat and high-fat diet decreases survival and alters cytokine signaling in neonatal mice with Staphylococcus epidermidis sepsis

This study shows that maternal low-fat and high-fat diets reduce survival and alter cytokine signaling in neonatal mice with Staphylococcus epidermidis sepsis.

Towards a holistic epidemiology of Streptococcus agalactiae using the BakRep repository

This study analyzes 37970 Streptococcus agalactiae genomes from BakRep to map population trends and identify metadata gaps in serotypes, lineage-specific genes, and AMR profiles.

Macrophage renewal in the small intestine governs early-life control of streptococci

This study shows that small intestine macrophage dynamics control GBS colonization and invasion in infant mice, with region-specific responses to the pathogen.

A murine model of adult gastrointestinal colonization by Group B Streptococcus

This study establishes a murine model of Group B Streptococcus colonization in the adult gastrointestinal tract and identifies the GBS capsule as a critical colonization factor.

Interactions between Streptococcus agalactiae and Candida albicans affect persistence and virulence

This study investigates how interactions between Streptococcus agalactiae and Candida albicans affect virulence and antibiotic effectiveness in vivo.

Meningeal γδ T cells facilitate bacterial entry into the brain in neonatal meningitis and trigger long-term behavioural sequelae

This study shows that meningeal γδ17 T cells promote bacterial entry into the brain during neonatal meningitis and cause long-term behavioral issues.

Characterization of the Cellular Immune Response to Group B Streptococcal Vaginal Colonization

This study investigates the cellular immune response to GBS vaginal colonization in mice, finding that neutrophils and γδ T cells contribute to host defense, while overall immune cell numbers remain stable.

Evidence of a novel sublineage of Streptococcus agalactiae in elephants from zoo populations in Germany

This study identifies a novel sublineage of Streptococcus agalactiae in German zoo elephants through whole-genome sequencing, showing phylogenetic divergence and clustering by zoo and genotype.

Ketone and glycolytic metabolism are key modulators of inflammation during neonatal sepsis

This study shows that inhibiting glycolysis or supplementing ketones can reduce inflammation and improve outcomes in neonatal sepsis by enhancing mitochondrial metabolism and disease tolerance.

GENOTYPIC DETECTION OF ANTIBIOTIC-RESISTANT GENES IN EMERGING BACTERIAL PATHOGENS FROM NEONATAL SEPSIS PATIENTS IN LAGOS

The paper investigates antibiotic-resistant genes in bacterial pathogens from neonatal sepsis cases in Lagos, finding high resistance to common antibiotics and identifying Meropenem as a viable treatment.

Harnessing systemic glycolysis-TCA cycle axis to boost the host defense against newborn infection

The paper shows that boosting TCA cycle activity through nutritional strategies improves neonatal host defense against infection by enhancing disease tolerance and resistance.

Genomic Characterisation of Group B Streptococcus from Argentina: Insights into Prophage Diversity, Virulence Factors and Antibiotic Resistance Genes

This study characterizes the genomic features of Group B Streptococcus isolates from Argentina, revealing prophage diversity, virulence factors, and antibiotic resistance genes across different clinical sources.

A CRISPRi Library Screen in Group B Streptococcus Identifies Surface Immunogenic Protein (Sip) as a Mediator of Multiple Host Interactions

This study uses CRISPRi to identify Sip as a key surface protein in GBS that modulates host interactions and pathogenesis.

Identification of Glyoxalase A in Group B Streptococcus and its contribution to methylglyoxal tolerance and virulence

This study identifies Glyoxalase A (gloA) in Group B Streptococcus as essential for methylglyoxal tolerance and virulence during infection.

Reduced glucose supply during neonatal infection attenuates neurological and renal pathology via modulation of innate and Th1 immunity

This study shows that reducing glucose supply in infected preterm pigs decreases neurological and renal damage by modulating innate and Th1 immunity.

The Streptococcus agalactiae LytSR two-component regulatory system promotes vaginal colonisation and virulence in vivo

This study shows that the LytSR two-component system in Streptococcus agalactiae enhances vaginal colonization and virulence by promoting biofilm formation and inflammatory responses.

A group B streptococcal type VII secreted LXG toxin mediates interbacterial competition and colonization of the female genital tract

This study identifies a GBS T7SS-secreted toxin, BltA, that mediates interbacterial competition and vaginal colonization by inhibiting Enterococcus faecalis in vitro and in vivo.

Three Accessory Gene Clusters Drive Host-Adaptation in Group B Streptococcus

The paper identifies three accessory gene clusters driving host adaptation in Group B Streptococcus across different hosts.