Axon Guidance and Neuronal Signaling

Sema7A and Sema4D Heterodimerization is Essential for Membrane Targeting and Neocortical Wiring

The paper shows that Sema7A and Sema4D heterodimerization is essential for membrane targeting and neocortical wiring, with a mutation in Sema4D causing epilepsy.

SorCS2 binds progranulin and regulates motor axon outgrowth

This study identifies SorCS2 as a receptor for progranulin that regulates motor axon outgrowth in zebrafish and mice, with loss-of-function phenotypes observed in both species.

Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant

This study shows that Vax1 intercellular transfer is necessary for proper RGC axon projection and normal visuomotor responses in mice.

Function of cell adhesion molecules in differentiation of ray sensory neurons in C. elegans.

The paper investigates the role of cell adhesion molecules in the differentiation and connectivity of ray sensory neurons in C. elegans, finding limited effects on axon trajectory and synaptic component accumulation in CAM mutants.

Presynaptic contact and activity opposingly regulate postsynaptic dendrite outgrowth

The paper investigates how presynaptic contact and activity opposingly regulate postsynaptic dendrite outgrowth during neural circuit development in Drosophila.

Cbln1 regulates axon growth and guidance in multiple neural regions

This study identifies Cbln1 as a novel axon growth and guidance cue in multiple CNS regions, revealing its role in early development and its interaction with Nrxn2.

Neuronal contact predicts connectivity in the C. elegans brain

The paper evaluates C. elegans connectomes to assess whether neuronal adjacency predicts synaptic connectivity, supporting Peters rule over the lock-and-key model.

Discoidin domain receptor regulates ensheathment, survival, and caliber of peripheral axons

This study identifies Ddr as a key regulator of non-myelinating glial ensheathment and its role in axon survival and caliber in Drosophila.

Microtubule retrograde flow retains neuronal polarization in a fluctuating state

The paper reveals that microtubule retrograde flow in developing neurons maintains a fluctuating state, which is essential for neuronal polarization by stabilizing microtubule density cycles before axon formation.

ADULT EXPRESSION OF SEMAPHORINS AND PLEXINS IS ESSENTIAL FOR MOTONEURON SURVIVAL

The paper identifies fourteen guidance genes essential for adult Drosophila nervous system survival and motility through RNAi screening, highlighting the role of Semaphorins and Plexins in motoneuron survival.

Semaphorin signaling restricts neuronal regeneration in C. elegans

This study investigates the role of semaphorin signaling in neuronal regeneration and locomotion recovery in C. elegans by analyzing knockout mutants and neuronal morphology.

A human DCC variant causing mirror movement disorder reveals an essential role for the Wave regulatory complex in Netrin/DCC signaling

This paper identifies a DCC variant causing mirror movement disorder and shows it disrupts the DCC-WAVE regulatory complex interaction, essential for Netrin-1 signaling.

KLC4 shapes axon arbors during development and mediates adult behavior

This study shows KLC4 is essential for axon branching and arborization in zebrafish sensory neurons and links it to anxiety-like behavior in adults.

Characterization of enhancer fragments in Drosophila robo2

The paper identifies enhancer fragments in Drosophila robo2 that regulate its expression in specific neural cell types and describes their activity in embryonic tissues.

Nhlh1 and Nhlh2, a global transcriptional mechanism regulating commissural axon projection via Robo3 activation

The paper identifies Nhlh1 and Nhlh2 as transcription factors that globally regulate commissural axon laterality through Robo3 activation in mammals.

Zebrafish Slit2 and Slit3 act together to regulate retinal axon crossing at the midline

The paper shows that Slit2 and Slit3 work together in zebrafish to guide retinal axons across the optic chiasm, with Slit2 having a more critical role.

The Vap33/Eph/Vav/Cdc42 complex confers temporal specification to the outgrowth of primary dendrites in Drosophila neurons

This study identifies the Vap33/Eph/Vav/Cdc42 complex as a temporal regulator of primary dendrite outgrowth in Drosophila neurons by integrating signals from multiple pathways.

Antagonistic activities of Fmn2 and ADF regulate axonal F-actin patch dynamics and the initiation of collateral branching

This study identifies Fmn2 and ADF as regulators of axonal F-actin patch dynamics, showing Fmn2 stabilizes these patches while ADF promotes their disassembly, influencing collateral branching.

Membrane tension propagation couples axon growth and collateral branching

This paper shows that membrane tension propagates along axons at 20 micrometers per second, influencing axon growth and branching through mechanical signaling.

Probabilistic axon targeting dynamics lead to individualized brain wiring

The paper shows that stochastic developmental processes explain individual wiring variation in the brain.

Constructive Connectomics: how neuronal axons get from here to there using gene-expression maps derived from their family trees

The paper proposes a mechanism for axon guidance using gene expression patterns from neural stem cell lineage trees, validated through simulations and mouse brain data.

Layer-specific developmentally precise axon targeting of transient suppressed-by-contrast retinal ganglion cells (tSbC RGCs)

This paper identifies a unique retinal ganglion cell type, tSbC RGCs, and maps their precise axon projections to specific brain regions with developmental precision.

Optimal frequency of perinatal retinal waves is essential for the precise wiring of visual axons in non-image forming nuclei

This study shows that spontaneous retinal waves before visual experience shape connectivity in non-image forming nuclei by analyzing transcriptomic profiles of RGCs in mice.

Developmental stage-specific spontaneous activity contributes to callosal axon projections

This study shows that spontaneous network activity during a critical period is necessary for callosal axon projections in the mouse visual cortex, but not fully synchronous activity.

Spontaneous thalamic activity modulates the cortical innervation of the primary visual nucleus of the thalamus

This study shows that spontaneous thalamic activity influences the timing and spatial organization of corticogeniculate innervation in the developing visual thalamus.

GPC3-Unc5D complex structure and role in cell migration

This study determines the structure of the GPC3-Unc5D complex and shows its role in guiding neuronal and cancer cell migration.

Self-avoidance alone does not explain the function of Dscam1 in mushroom body axonal wiring

The paper shows that reduced Dscam1 isoform diversity, not just self-avoidance, causes defects in mushroom body axonal wiring in Drosophila.

Molecular specification of cortico-brainstem versus corticospinal projection neurons in development

The paper identifies molecular markers distinguishing cortico-brainstem and corticospinal projection neurons during development using single-cell RNA sequencing.

Transcription Factor Acj6 Controls Dendrite Targeting via CombinatorialCell-Surface Codes

This study identifies Acj6 as a transcription factor that controls dendrite targeting in Drosophila PNs by regulating combinatorial expression of cell-surface proteins.

Prenatal alcohol exposure alters axon formation and Robo/Slit guidance cue expression in the internal capsule at E15.5

This study shows prenatal alcohol exposure alters axon formation and Robo/Slit guidance cue expression in the internal capsule of E15.5 embryos, affecting axon crossing differently in males and females.