B. Yang

Proteasome Regulation by Reversible Tyrosine Phosphorylation at the Membrane

This study identifies a novel mechanism where Src-mediated phosphorylation of Rpt2-Y439 regulates proteasome function at cellular membranes, impacting cancer therapy response.

Anatomical and cellular heterogeneity in the mouse oviduct-- its potential roles in reproduction and preimplantation development

This study examines the anatomical and cellular structure of the mouse oviduct, identifying new features and roles in reproduction and preimplantation development.

Seed hemicelluloses tailor mucilage properties and salt tolerance

This study investigates the role of hemicelluloses in seed mucilage properties and salt tolerance by analyzing mutants in Arabidopsis.

Human Cytomegalovirus Drives WDR5 to the Virion Assembly Compartment to Facilitate Virion Assembly

This paper shows HCMV drives WDR5 to the virion assembly compartment to facilitate virion assembly, expanding its role beyond nuclear egress.

Functional analysis of the teosinte branched 1 genes in the tetraploid switchgrass (Panicum virgatum L.) by CRISPR/Cas9-directed mutagenesis

This study uses CRISPR/Cas9 to generate non-chimeric mutants of the Pvtb1 genes in switchgrass, showing they negatively regulate tillering and biomass production.

Polarized endosome dynamics engage cytosolic Par-3 and dynein during asymmetric division

The paper shows that Par-3 and dynein mediate polarized endosome movement during asymmetric division, leading to Notch signaling asymmetry in daughter cells.

Integrin αvβ8 on T cells is responsible for suppression of anti-tumor immunity in multiple syngeneic models and is a promising target for tumor immunotherapy

This study shows that blocking integrin αvβ8 on T cells enhances anti-tumor immunity in multiple syngeneic models and is effective even when tumor cells do not express the integrin.

Double-targeted knockdown of miR-21 and CXCR4 inhibits malignant glioma progression by suppression of the PI3K/AKT and Raf/MEK/ERK pathways

This study shows that knocking down both miR-21 and CXCR4 inhibits glioma progression more effectively than single-targeted knockdown, by suppressing PI3K/AKT and Raf/MEK/ERK pathways.

Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules

This study identifies membraneless protein granules formed by RTK oncoproteins that activate RAS/MAPK signaling independently of lipid membranes in cancer.

A Versatile Oblique Plane Microscope for Large-Scale and High-Resolution Imaging of Subcellular Dynamics.

This paper introduces an improved oblique plane microscope with enhanced resolution and usability, demonstrating its application in imaging various subcellular dynamics and challenging biological phenomena.

Reprogramming the endogenous type III-A CRISPR-Cas system for genome editing, RNA interference and CRISPRi screening in Mycobacterium tuberculosis

This paper reprograms the endogenous CRISPR-Cas10 system in Mycobacterium tuberculosis for efficient gene editing, RNA interference, and genome-wide screening, enabling functional genomics studies and drug/vaccine development.

Genetic elucidation of complex biochemical traits mediating maize innate immunity

The paper identifies ten genes in maize that drive antibiotic biosynthesis, revealing a resilient pathway critical for disease resistance.

Development of the yeast Saccharomyces cerevisiae as a biosensor for the toxicity detection of toxic substances

This paper develops a yeast biosensor to detect chlorothalonil and heavy metals toxicity, showing improved sensitivity through optimized culture conditions and morphological, ROS, DNA, and caspase 3 activity analysis.

Multiplexed imaging of nucleome architectures in single cells of mammalian tissue

The paper develops a method to measure multiscale chromatin folding and nuclear structures in single cells, revealing cell-type-specific architectures and physical principles of chromatin organization.

The Hippo pathway origin and its oncogenic alteration in evolution

This study traces the evolutionary origin of the Hippo pathway from unicellular ancestors and examines its oncogenic alterations in mammals.

Growth under high light and elevated temperature affects metabolic responses and accumulation of health-promoting metabolites in kale varieties

This study shows that high light and elevated temperature reduce certain glucosinolates but increase health-promoting metabolites in kale varieties.

The maize heterotrimeric G-protein β subunit controls shoot meristem development and immune responses.

This study shows that the maize Gβ subunit controls both shoot meristem development and immune responses, with implications for optimizing growth and defense tradeoffs in crops.

An efficient method to clone TAL effector genes from Xanthomonas oryzae using Gibson assembly

This paper introduces an efficient method to clone TAL effector genes from Xanthomonas oryzae using Gibson assembly, significantly reducing the time required compared to traditional methods.

Crl activates transcription by stabilizing the active conformation of the master stress factor σS

This study determines the structure of an E. coli transcription activation complex and shows that Crl stabilizes σS to activate transcription without DNA contact.

First report of Telenomus remus parasitizing Spodoptera frugiperda and its natural parasitism in South China

The paper reports the first detection of Telenomus remus parasitizing Spodoptera frugiperda eggs in South China and estimates natural parasitism rates.

TCR repertoire analysis reveals effector memory T cells differentiation into Th17 cells in rheumatoid arthritis

This study analyzes TCR repertoires in RA patients and identifies clonal expansion and shared repertoires between EMT and Th17 cells, correlating TCR diversity with disease activity.

Heterologous expression of Stlac2, a laccase isozyme of Setosphearia turcica, and the ability of decolorization of malachite green

This study heterologously expresses Stlac2 from Setosphaeria turcica and demonstrates its ability to decolorize malachite green with high efficiency.

Modelling the distribution of Aedes aegypti and Aedes albopictus using climate, host density and interspecies competitive effects

The paper develops a predictive model for the spatial distribution of Aedes aegypti and Aedes albopicti in Florida using climate, host density, and competitive interactions, achieving high validation accuracy.

Multicolor fluorescent imaging by space-constrained computational hyperspectral imaging

This paper introduces a computational hyperspectral imaging method that improves reconstruction precision in multicolor fluorescent imaging by using spatial constraints, validated with simulated and experimental data.

Strong positive biodiversity-productivity relationships in a subtropical forest experiment

The paper demonstrates a strong positive biodiversity-productivity relationship in a subtropical forest experiment, showing increased productivity with species richness and complementary effects over time.

Human Cytomegalovirus Immediate-Early 1 Protein Causes Loss of SOX2 from Neural Progenitor Cells by Trapping Unphosphorylated STAT3 in the Nucleus

This study shows HCMV IE1 protein causes SOX2 loss in NPCs by trapping unphosphorylated STAT3 in the nucleus, leading to neurodevelopmental damage.

Fitness effects of altering gene expression noise in Saccharomyces cerevisiae

The paper quantifies how altering gene expression noise in yeast affects fitness, showing it can be beneficial or deleterious depending on average expression levels.

High Numerical Aperture Epi-illumination Selective Plane Illumination Microscopy

This paper introduces a high numerical aperture epi-illumination SPIM system for fast and high-resolution volumetric imaging of live cells and single-molecule super-resolution microscopy.

5-hydroxy-4′-nitro-7-propionyloxy-genistein inhibited invasion and metastasis via inactivating wnt/β-catenin signal pathway in human endometrial carcinoma JEC cells

This study investigates the anticancer effects of HNPG on JEC cells, finding it inhibits proliferation, invasion, and metastasis by inactivating the Wnt/β-catenin pathway.

Impaired phloem loading in genome-edited triple knock-out mutants of SWEET13 sucrose transporters

The paper identifies three ZmSWEET13 paralogs as essential for phloem loading in maize, showing their role in carbon allocation and agronomical traits.