D. Wang

Single cell RNA-seq reveals cellular diversity and developmental characteristics of human infant retina

This study uses single-cell RNA-seq to analyze human infant retina, identifying cell types, communication networks, and developmental changes, providing a resource for retinal research and regenerative medicine.

Single cell RNA sequencing reveals cellular diversity of trisomy 21 retina

This study uses single-cell RNA sequencing to analyze the cellular diversity and molecular markers in the retina of a trisomy 21 fetus, revealing communication networks and novel markers.

Extension of the in vivo haploid induction system from diploid maize to hexaploid wheat

This study extends the in vivo haploid induction system from diploid maize to hexaploid wheat by knocking out homologous genes, achieving 2%-3% haploid induction with 30%-60% seed setting rate.

Noda-like RNA viruses infecting Caenorhabditis nematodes: sympatry, diversity and reassortment

The paper identifies a new RNA virus infecting Caenorhabditis nematodes, describes co-infections and reassortment patterns, and shows host-virus genotype interactions affecting competition.

Function and clinical relevance of RHAMM isoforms in pancreatic tumor progression

This study identifies RHAMMB as a key driver of pancreatic tumor metastasis, showing its upregulation in PNETs and correlation with poor patient survival through EGFR signaling.

Infection of Plasmodiophora brassicae changes the fungal endophyte community of tumourous stem mustard roots as revealed by high-throughput sequencing and culture-dependent methods

This study examines how Plasmodiophora brassicae infection alters the fungal endophyte community in stem mustard roots using sequencing and culture methods, finding reduced diversity and shifts in dominant taxa.

Oligotyping and Genome-Resolved Metagenomics Reveal Distinct Candidatus Accumulibacter Communities in Full-Scale Side-Stream versus Conventional Enhanced Biological Phosphorus Removal (EBPR) Configurations

This study uses oligotyping and genome-resolved metagenomics to identify distinct Candidatus Accumulibacter communities in different EBPR configurations, revealing new MAGs and clade-level diversity.

The role of genetic constraints and social environment in explaining female extra-pair mating

The study tests the intersexual pleiotropy hypothesis by examining genetic and environmental influences on female extra-pair mating in zebra finches, finding no genetic homology between male and female promiscuity.

Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration

The paper identifies miR-199 as a suppressor of neutrophil migration and inflammation by targeting CDK2, revealing a noncanonical role for CDK2 in cell polarity and chemotaxis.

Cancer gene therapy by NF-κB-activated cancer cell-specific expression of CRISPR/Cas9 targeting to telomere

This paper demonstrates a gene therapy approach using NF-κB-activated CRISPR/Cas9 to specifically target and kill cancer cells without affecting normal cells.

Single-cell transcriptome provides novel insights into antler stem cells, a cell type capable of mammalian organ regeneration

The paper uses single-cell RNA sequencing to analyze antler stem cells, finding they form a homogeneous population with unique gene expression patterns and potential as a model for regeneration.

Gene activation by a CRISPR-assistant trans enhancer

This study develops a CRISPR-assistant trans enhancer to efficiently activate gene expression by combining dCas9-VP64/sgRNA with a CMV enhancer.

Multilocus sequence analysis, a rapid and accurate identification tool for taxonomic classification, evolutionary relationship and population biology of the genus Shewanella.

This paper establishes a multilocus sequence analysis (MLSA) method using six protein-coding genes to classify Shewanella strains, revealing evolutionary relationships and population biology.

Reference genes for RT-qPCR normalisation in different tissues, developmental stages and stress conditions of Hypericum perforatum

This study identifies stable reference genes for RT-qPCR normalization in Hypericum perforatum across tissues, developmental stages, and stress conditions.

Beyond a ribosomal RNA methyltransferase, the wider role of MraW in DNA methylation, motility and colonization in Escherichia coli O157:H7

This paper identifies MraW as a DNA methylase in E. coli O157:H7, showing its role in motility, colonization, and virulence through genome-wide methylation and regulation of flagellar genes.

Identification of genome-wide nucleotide sites associated with mammalian virulence in influenza A viruses

This study identifies genome-wide nucleotide sites associated with mammalian virulence in influenza A viruses and develops machine-learning models to predict virulence.

Intensive and Specific Feedback Self-control of the Argonauts and MicroRNA Targeting Activity

This study reveals that miRNAs directly feedback-regulate their targeting machinery mRNAs, but not upstream biogenesis or downstream effector mRNAs, uncovering segment-specific feedback auto-regulation of the miRNA pathway.

Genome-wide identification and expression specificity analysis of the DNA methyltransferase gene family under adversity stresses in cotton

This study identifies and analyzes DNA methyltransferase genes in cotton, showing their functional diversity and stress-specific expression patterns.

Effect of Live Attenuated Influenza Vaccine on Pneumococcal Carriage

This study tests if LAIV affects pneumococcal carriage in humans, finding transient increases in bacterial density but no overall change in acquisition rates.

EZH2 co-opts gain-of-function p53 mutants to promote cancer growth and metastasis

This study identifies EZH2 as a p53 mRNA-binding protein that enhances translation of gain-of-function p53 mutants, promoting cancer growth and metastasis, and shows that inhibiting EZH2 causes synthetic lethality in these cells.

Cancer therapy with a CRISPR-assistant telomerase-activating gene expression system

The paper develops a gene therapy system that uses telomerase activity to kill cancer cells in mice without affecting normal cells.

Generation of a novel growth-enhanced and reduced environmental impact transgenic pig strain

This study generates transgenic pigs expressing microbial enzymes to enhance feed digestion and reduce nutrient emissions, showing improved growth and lower environmental impact.

Genetic footprint of Population Fragmentation and Contemporaneous Decline in the endangered Yangtze Finless Porpoise

The paper analyzes genetic data from Yangtze finless porpoises to show population fragmentation, low genetic diversity, and recent decline linked to habitat degradation and human activity.

Genetic load and mutational meltdown in cancer cell populations

The paper studies mutational meltdown in HeLa cancer cell populations, finding high rates of deleterious copy number variations and significant fitness reduction per mutation.

Members of the abscisic acid co-receptor PP2C protein family mediate salicylic acid-abscisic acid crosstalk

This study identifies SA-mediated suppression of ABA signaling via PP2C phosphatases, revealing a molecular mechanism for hormone crosstalk in plant stress responses.