D. Wang

Mesenchymal stem cells suppress leukemia via macrophage-mediated functional restoration of bone marrow microenvironment

This study shows that intra-BM MSC transfusion restores the BM microenvironment, suppresses leukemia, and reprograms macrophages to reduce tumor burden.

The role of CAPG in molecular communication between the embryo and the uterine endometrium: Is its function conserved in species with different implantation strategies?

This study shows that CAPG, a conserved protein, induces transcriptional changes in endometrial cells of humans and cattle, potentially aiding implantation across species with different implantation strategies.

Branched chain amino acid aminotransferase 2 Regulates Ferroptotic Cell Death in Cancer Cells

This study identifies BCAT2 as a suppressor of ferroptosis in cancer cells, showing its role in regulating glutamate levels and enhancing resistance to ferroptosis-inducing therapies.

The separation of Antler Polypeptide and its effects on the proliferation and osteogenetic differentiation of Bone Marrow Mesenchymal Stem Cells

This study investigates how antler polypeptide affects the proliferation and osteogenic differentiation of rat bone marrow mesenchymal stem cells, finding that antler polypeptide B significantly enhances these processes.

Integrin Affinity Modulation Critically Regulates Atherogenic Endothelial Activation in vitro and in vivo

This study shows that integrin affinity modulation is critical for endothelial activation in response to atheroprone hemodynamics and oxidized lipoproteins, with talin1 L325R mutations impairing this process.

Aberrant pathogenic GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe pulmonary syndrome patients of a new coronavirus

This study identifies aberrant GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe 2019-nCoV patients, linking them to immune damage and mortality.

Intracorneal delivery of HSV-targeting CRISPR/Cas9 mRNA prevents herpetic stromal keratitis

This study demonstrates that intracorneal delivery of HSV-1-targeting CRISPR/Cas9 mRNA prevents herpetic stromal keratitis in both animal models and human-derived corneas.

Effects of rhein on bile acid homeostasis in rats

This study examines the effects of rhein on bile acid homeostasis in rats, showing dose-dependent changes in bile acid levels and transporter expression without liver or kidney toxicity.

Heterogeneity of proteome dynamics between connective tissue phases of adult tendon

The paper measures protein turnover rates in collagen and glycoprotein phases of rat Achilles tendon using isotope labeling and mass spectrometry, finding significant differences in proteome dynamics between the two ECM phases.

Chlorotoxin Redirects Chimeric Antigen Receptor T Cells for Specific and Effective Targeting of Glioblastoma

This study develops a CAR T cell therapy using chlorotoxin to target glioblastoma with high specificity and potency, overcoming tumor heterogeneity challenges.

Super elongation complex as a targetable dependency in diffuse midline glioma

This study identifies AFF4 as a therapeutic target in diffuse midline glioma by showing CDK9 inhibitors inhibit the super elongation complex and induce anti-tumor effects.

Specificity and effector functions of non-neutralizing gB-specific monoclonal antibodies isolated from healthy individuals with human cytomegalovirus infection

This study characterizes non-neutralizing gB-specific monoclonal antibodies from HCMV-infected individuals, revealing their binding specificity, genotype preference, and effector functions like ADCP and ADCC.

Tuft cells restrain pancreatic tumorigenesis through paracrine eicosanoid signaling

This study shows that tuft cells suppress pancreatic tumorigenesis by producing anti-inflammatory prostaglandin D2, which inhibits stromal activation, and identifies their protective role in early disease progression.

Proximate causes of infertility and embryo mortality in captive zebra finches

The paper investigates causes of infertility and embryo mortality in captive zebra finches, finding inbreeding, age-related decline, and poor nutrition significantly impact reproductive success, but explain only a small portion of the variance.

Effect of the divalent cations zinc and calcium on the structure and mechanics of reconstituted vimentin intermediate filaments

This study examines how zinc and calcium ions affect the structure and mechanics of vimentin intermediate filaments, showing that zinc is more effective at lower concentrations and that ion binding can compete.

Mathematical deconvolution of CAR T-cell proliferation and exhaustion from real-time killing assay data

This paper uses a mathematical model to analyze CAR T-cell killing dynamics in glioma, showing dose-dependent effects on proliferation and exhaustion.

A multi-omic cohort as a reference point for promoting a healthy human gut microbiome

The paper presents a large multi-omic cohort of 2,183 adults to identify correlations between gut microbiome features and various health-related factors, validated in an additional cohort.

Multistep metabolic engineering of Bacillus licheniformis to improve pulcherriminic acid production

This paper improves pulcherriminic acid production in Bacillus licheniformis through multistep metabolic engineering, achieving a record yield of 556.1 mg/L.

Exploiting a Mechanical Perturbation of Titin Domain to Identify How Force Field Parameterization Affects Protein Refolding Pathways

The paper examines how different force fields affect protein refolding pathways using a mechanically perturbed titin domain model and a helical peptide, finding significant differences in refolding ability and helical lifetimes.

The inverse relationship between fibronectin and neuroligins in the embryonic rat colon

The paper investigates the inverse relationship between fibronectin and neuroligins in the embryonic rat colon, showing direct regulation and negative correlation.

Entry by multiple picornaviruses is dependent on a pathway that includes TNK2, WASL and NCK1

This study identifies TNK2, WASL, and NCK1 as host factors critical for multiple picornavirus infections, showing they function in a common pathway during viral entry.

Characterization of TAG-63 and its role on axonal transport in C. elegans

This study identifies TAG-63 as a neurofilament-like protein in C. elegans and shows its role in axonal transport by interacting with UNC-104 and affecting motor speed and filament stability.

Calorie restriction intervention induces enterotype-associated BMI loss in nonobese individuals

This study shows that calorie restriction leads to BMI loss in nonobese individuals, with variations linked to gut microbiota enterotypes.

The C. elegans RIG-I homolog drh-1 mediates the Intracellular Pathogen Response upon viral infection

This paper shows that drh-1 in C. elegans mediates the Intracellular Pathogen Response (IPR) to viral infection, acting as a pattern-recognition receptor independent of its role in RNAi.

ALI-1, candidate gene of B1 locus, is associated with awn length and grain weight in common wheat

This study identifies ALI-1 as a candidate gene for the B1 locus, showing its role in regulating awn length and grain weight in wheat through cytokinin suppression.

Diverse noncanonical PAMs recognized by SpCas9 in human cells

This study identifies multiple noncanonical PAMs recognized by SpCas9 in human cells, improving understanding of off-target mutation risks.

Modern human origins: multiregional evolution of autosomes and East Asia origin of Y and mtDNA

The paper challenges the Recent Out of Africa model by proposing multiregional evolution of autosomes and East Asian origin of modern Y and mtDNA through hybridization with archaic humans.

Pneumococcal Colonisation is an Asymptomatic Event in Healthy Adults using an Experimental Human Colonisation Model.

This study investigates whether pneumococcal colonisation in healthy adults is symptomatic using an experimental challenge model, finding it asymptomatic regardless of bacterial density or viral co-colonisation.

Enrichment in conservative amino acid changes among fixed and standing missense variations in slow evolving proteins

The paper finds that conservative amino acid changes are more common in fixed and standing missense variations of slow evolving proteins, suggesting these variations are more neutral and suitable for phylogenetic inferences.

CDK1 phosphorylates ULK1-ATG13 complex to regulate mitotic autophagy and Taxol chemosensitivity

The paper shows CDK1 phosphorylates ULK1-ATG13 in mitosis to regulate autophagy and Taxol sensitivity, with implications for cancer therapy.