Dementia and Cognitive Impairment Research

Predicting the future development of mild cognitive impairment in the cognitively healthy elderly

The paper identifies reduced grey matter density in the left entorhinal cortex as a biomarker for predicting mild cognitive impairment in cognitively healthy elderly individuals.

Increasing objective cardiometabolic burden associated with attenuations in the P3b event-related potential component in older adults

This study finds that higher cardiometabolic burden in older adults is associated with reduced P3b ERP amplitude during working memory tasks.

Physical activity and risk of Alzheimer’s disease: a two-sample Mendelian randomization study

This study uses Mendelian randomization to assess if physical activity reduces Alzheimer's disease risk, finding no significant protective effect.

Data-driven detection of latent atrophy factors related to phenotypical variants of posterior cortical atrophy

The paper identifies four latent atrophy factors in posterior cortical atrophy using Bayesian modeling, finding that most patients exhibit mixed profiles rather than distinct variants.

Alzheimer's disease susceptibility gene apolipoprotein e (APOE) and blood biomarkers in UK Biobank (N=395,769).

The paper investigates associations between APOE genotypes and blood biomarkers in UK Biobank, finding both expected and unexpected links to AD risk factors.

Fully Bayesian longitudinal unsupervised learning for the assessment and visualization of AD heterogeneity and progression

The paper develops a Bayesian longitudinal clustering framework to identify distinct AD brain atrophy patterns and their progression, revealing heterogeneity in disease progression.

Functional connectivity alterations of the temporal lobe and hippocampus in semantic dementia and Alzheimer's disease

This study compares functional connectivity in temporal lobe regions between Alzheimer's disease, semantic dementia, and healthy controls, identifying shared and distinct patterns of dysconnectivity.

Longitudinal ComBat: A Method for Harmonizing Longitudinal Multi-scanner Imaging Data

The paper introduces longitudinal ComBat to harmonize multi-scanner imaging data, showing it improves detection of longitudinal changes and controls type I error better than existing methods.

Baseline Semantic Fluency Is Associated with Six-Year Progression to Mild Cognitive Impairment in Middle-Aged Men

The paper shows that poor episodic memory and semantic verbal fluency in middle-aged men predict progression to mild cognitive impairment within six years.

Predicting Clinical Dementia Rating Using Blood RNA Levels

The paper uses blood RNA levels and machine learning to predict Clinical Dementia Rating (CDR) groups, finding that combining nonsignificant probes improves classification accuracy.

Gene expression imputation provides insight into the genetic architecture of frontotemporal dementia

This study uses gene expression imputation to identify candidate genes and tissue-specific associations linked to frontotemporal dementia risk loci.

A Non-Synonymous SHARPIN Variant is Associated with Limbic Degeneration and Family History of Alzheimer’s Disease

The paper identifies a SHARPIN variant associated with limbic system atrophy and family history of Alzheimer’s disease using MRI and genome-wide data.

Building memories on prior knowledge: behavioral and fMRI evidence of impairment in early Alzheimer's Disease

This study investigates whether prior knowledge enhances memory encoding in early Alzheimer's Disease using fMRI, finding that patients do not benefit from pre-experimental knowledge while controls do.

Genetic Variants and Functional Pathways Associated with Resilience to Alzheimer's Disease

This study identifies genetic variants and pathways associated with cognitive resilience to Alzheimer's disease, finding a novel locus linked to bile acid metabolism and methylation changes.

Predicting future cognitive decline from non-brain and multimodal brain imaging data in healthy and pathological aging

The paper predicts future cognitive decline using non-brain and multimodal brain imaging data in healthy and pathological aging, finding that non-brain data and structural MRI improve predictions.

18F-FDG-PET Hyperactivity in Alzheimers Disease Cerebellum and Primary Olfactory Cortex

This study identifies FDG hyper-metabolism in cerebellar and olfactory regions in Alzheimer's disease, suggesting disrupted inhibitory networks.

Quantifying uncertainty in brain-predicted age using scalar-on-image quantile regression

The paper predicts brain age from MRI scans and provides prediction intervals to quantify uncertainty in age estimation for different cognitive states.

Cognitive tests that identify high risk of conversion to dementia in Parkinson's disease.

The paper identifies key neuropsychological tests that predict dementia conversion in Parkinson's disease patients using logistic regression and elastic net methods.

APOE4 status is related to differences in memory-related brain function in asymptomatic older adults: Baseline analysis of the PREVENT-AD task fMRI dataset

The paper analyzes fMRI data from asymptomatic older adults to investigate how APOE4 genetic status affects memory-related brain activity during a spatial source recollection task.

Clinical and biomarker changes in sporadic Alzheimer's disease

This study examines how amyloid-beta biomarkers and clinical profiles change in sporadic Alzheimer's disease, finding that amyloid changes are inconsistent with clinical and imaging markers during progression.

ATN status in amnestic and non-amnestic Alzheimer's disease and frontotemporal lobar degeneration

This paper evaluates the ATN framework's accuracy in diagnosing Alzheimer's disease subtypes and frontotemporal lobar degeneration using cerebrospinal fluid biomarkers, finding that non-amnestic Alzheimer's patients have lower tau levels and the framework is less sensitive to frontotemporal lobar degeneration.

Platelet miRNA bio-signature discriminates between dementia with Lewy bodies and Alzheimer disease

The paper identifies a 7-miRNA biosignature in platelets that distinguishes dementia with Lewy bodies from Alzheimer disease.

Self-reported health behaviors and longitudinal cognitive performance: Results from the Wisconsin Registry for Alzheimer’s Prevention

This study examines the association between multiple self-reported health behaviors and cognitive decline in a cohort of non-demented middle-aged individuals, finding limited significant associations.

Severe Hyposmia Distinguishes Neuropathologically Confirmed Dementia with Lewy Bodies from Alzheimer’s Disease Dementia

This study finds that severe hyposmia (reduced sense of smell) is a distinguishing feature between dementia with Lewy bodies and Alzheimer’s disease dementia, based on neuropathological confirmation.

Path integration changes as a cognitive marker for vascular cognitive impairment? - a pilot study

This study investigates path integration impairments in vascular cognitive impairment and Alzheimer's disease, finding egocentric deficits specific to VCI and similar allocentric deficits in both groups.

Mid-life and late life activities and their relationship with MRI measures of brain structure and functional connectivity in the UK Biobank cohort

This study examines the relationship between mid-life and late life leisure activities and MRI measures of brain structure and functional connectivity in older adults from the UK Biobank.

Development and validation of a deep learning framework for Alzheimers disease classification

This paper develops a deep learning framework that classifies Alzheimer's disease using MRI, age, gender, and MMSE scores, achieving high accuracy across multiple datasets.

A comparison of resting state EEG and structural MRI for classifying Alzheimer’s disease and mild cognitive impairment

This study compares resting state EEG and structural MRI for classifying Alzheimer’s disease and mild cognitive impairment, finding MRI outperforms EEG in most cases.

Physical and mental health characteristics of adults with subjective cognitive decline: A study of 3,407 people aged 18-81 years from an MTurk-based U.S. national sample

The paper examines physical and mental health correlates of subjective cognitive decline in a large U.S. sample, finding strong associations with poor sleep, BMI, and psychological factors across age groups.

The Longitudinal Assessment of Neuropsychiatric Symptoms in Mild Cognitive Impairment and Alzheimer’s disease and their Association with White Matter Hyperintensities in the National Alzheimer’s Coordinating Center’s Uniform Data Set

This study examines the relationship between white matter hyperintensities and neuropsychiatric symptoms in Alzheimer’s disease and mild cognitive impairment, finding significant longitudinal associations with irritability and agitation.