Dementia and Cognitive Impairment Research

Alzheimer's genetic risk effects on cerebral blood flow are spatially consistent and proximal to gene expression across the lifespan

This study shows that Alzheimer's genetic risk reduces cerebral blood flow consistently across age groups and is linked to nearby gene expression.

Locus coeruleus MRI contrast is associated with cortical thickness in older adults

The paper examines the relationship between locus coeruleus MRI contrast and cortical thickness in older and younger adults, finding a positive association in specific brain regions.

Time between milestone events in the Alzheimer's disease amyloid cascade

The paper estimates the time-course of pathological markers and cognitive dysfunction in Alzheimer's disease relative to Aβ-positivity, finding tau and cognitive changes occur years before significant Aβ accumulation.

Diet, psychosocial stress, and Alzheimer's disease-related neuroanatomy in female nonhuman primates

The paper examines how diet and psychosocial stress affect brain anatomy in nonhuman primates, finding that Western diet increases AD-related brain regions while Mediterranean diet may protect against them.

Deep learning detection of informative features in tau PET for Alzheimer' s disease classification

This paper develops a deep learning framework using tau PET scans to classify Alzheimer's disease and identifies key brain regions associated with the disease.

Alteration of perivascular spaces in early cognitive decline

The paper shows that early cognitive dysfunction is associated with altered perivascular space presence and distribution, linked to tau tangle deposition in Alzheimer's disease pathology.

Alzheimer Disease Neuropathological Comorbidities Are Common in the Younger-Old

This study examines neuropathological comorbidities in Alzheimer's disease dementia across age groups, finding that comorbidities are common even in younger-onset cases and vary with age.

Hearing loss in Alzheimer Disease is associated with altered serum lipidomic biomarker profiles

The paper investigates serum lipidomic profiles in Alzheimer Disease patients with and without hearing loss, finding altered phosphatidylcholine levels associated with hearing loss.

Selecting the most important self-assessed features for predicting conversion to Mild Cognitive Impairment with Random Forest and Permutation-based methods

This study identifies key self-reported features predicting conversion to Mild Cognitive Impairment using random forest and permutation-based methods in a longitudinal cohort.

Serum Metabolites Associate with Brain Amyloid Beta Deposition, Cognitive Dysfunction, and Alzheimers Disease Progression

The paper identifies serum metabolites associated with brain amyloid-beta deposition, cognitive dysfunction, and progression to Alzheimer's disease.

Functional Ensemble Survival Tree: Dynamic Prediction of Alzheimer's Disease Progression Accommodating Multiple Time-Varying Covariates

The paper develops a functional ensemble survival tree framework to predict Alzheimer's disease progression using time-varying biomarkers and baseline covariates, showing good performance in simulations and ADNI data.

Accurate brain age prediction using recurrent slice-based networks

This paper introduces a 2D slice-based recurrent neural network for brain age prediction, achieving comparable or better performance than existing methods with fewer parameters and faster training.

Sex-Dependent Age Trajectories of Subcortical Brain Structures: Analysis of Large-Scale Percentile Models and Shape Morphometry

The paper creates normative percentile charts for subcortical brain volumes across adulthood and examines age-by-sex interactions and associations with APOE genotype in a large UK Biobank sample.

Associations between Early Midlife Lifestyle Behaviors, Young Adult Cognitive Reserve and Advanced Predicted Brain Age in Late Midlife

This study examines how early midlife lifestyle behaviors and young adult cognitive reserve influence late midlife brain aging and mild cognitive impairment.

Regular Tai Chi Practice Is Associated with Improved Memory as well as Structural and Functional Integrity of the Hippocampal Formation in the Elderly

This study finds that regular Tai Chi practice in elderly women improves memory and structural-functional integrity of the hippocampal formation compared to brisk walking.

Plasma neurofilament light protein correlates with diffusion tensor imaging metrics in frontotemporal dementia

This study shows plasma neurofilament light chain levels correlate with diffusion tensor imaging metrics in frontotemporal dementia, indicating a link between blood biomarkers and white matter degeneration.

Establishing two principal dimensions of cognitive variation in Logopenic Progressive Aphasia

The paper identifies two independent cognitive dimensions in Logopenic Progressive Aphasia using principal component analysis, revealing non-linguistic cognitive variability independent of language deficits.

Hippocampal and parahippocampal grey matter structural integrity assessed by multimodal imaging is associated with episodic memory in old age

The paper introduces a multimodal imaging approach to assess grey matter structural integrity in older adults and finds it correlates with episodic memory, particularly in men.

Causal associations between potentially modifiable risk factors and the Alzheimer's phenome: A Mendelian randomization study

This study uses Mendelian randomization to assess causal relationships between 22 risk factors and the Alzheimer's phenome, finding education, blood pressure, cholesterol, smoking, and BMI have causal effects.

Learning Patterns of the Ageing Brain in MRI using Deep Convolutional Networks

This paper uses a 3D CNN to predict brain age from MRI data and finds that prediction errors correlate with clinical measurements and image-derived phenotypes.

Multimodal Brain Age Gap as a Mediating Indicator in the Relation between Modifiable Dementia Risk Factors and Cognitive Functioning

The paper investigates how multimodal brain age gap mediates the relationship between modifiable dementia risk factors and cognitive decline in a population-based cohort.

Genetic risk for Alzheimer`s disease predicts hippocampal volume through the lifespan

This study shows genetic risk for Alzheimer's disease affects hippocampal volume throughout life in a healthy population.

Bundle-specific associations between white matter microstructure and Aβ and tau pathology at their connecting cortical endpoints in older adults at risk of Alzheimer's disease

The paper examines associations between white matter microstructure and Aβ/tau pathology in specific brain bundles in at-risk older adults, finding diffusion metrics linked to Aβ and tau levels at cortical endpoints.

Predicting Alzheimer's disease progression trajectory and clinical subtypes using machine learning

This paper uses machine learning to predict Alzheimer's disease progression rates and classify clinical subtypes based on early clinical data.

Predicting future regional tau accumulation in asymptomatic and early Alzheimer's disease

This study uses machine learning to predict future regional tau accumulation in asymptomatic and early Alzheimer's disease using multimodal data, showing improved accuracy over traditional measures.

Ontario Neurodegenerative Disease Research Initiative (ONDRI): Structural MRI methods & outcome measures

This paper describes the neuroimaging pipeline methods used in the ONDRI study to generate regional brain tissue volumes and neurovascular markers from structural MRI data.

Predicting Alzheimer's disease progression using deep recurrent neural networks

This paper predicts Alzheimer's disease progression using a minimal recurrent neural network, showing better performance than baseline methods when handling missing data with model-based imputation.

Differential brain atrophy and neurogenetic profiles in cognitively-defined Alzheimer's disease subgroups

The paper identifies cognitive subgroups in Alzheimer's disease based on MRI-derived atrophy patterns and links them to specific biological pathways using transcriptomic data.

Defining and predicting transdiagnostic categories of neurodegenerative disease

This paper defines transdiagnostic disease categories using histopathological data and predicts cluster membership from CSF and genotype data with high accuracy.

Proper names from story recall are associated with beta-amyloid in cognitively unimpaired adults at risk for Alzheimer's disease

The paper investigates if story recall of proper names is linked to beta-amyloid levels in cognitively unimpaired adults at risk for Alzheimer's disease, finding an association with delayed recall.