Schizophrenia research and treatment

Theta phase synchrony is sensitive to corollary discharge abnormalities in early illness schizophrenia but not in the clinical high-risk syndrome

The paper investigates theta phase synchrony and N1 suppression in schizophrenia and clinical high-risk groups, finding theta inter-trial coherence suppression is more sensitive to corollary discharge abnormalities in early illness schizophrenia.

Antipsychotic behavioral phenotypes in the mouse Collaborative Cross recombinant inbred inter-crosses (RIX)

This study identifies genetic factors influencing antipsychotic-induced adverse reactions in mice using RIX lines, finding strong strain and treatment interactions for behavioral phenotypes.

CALCIUM-BINDING PROTEINS ARE ALTERED IN THE CEREBELLUM IN SCHIZOPHRENIA

The paper identifies altered calcium-binding proteins in the cerebellum of schizophrenia patients, linking them to synaptic dysfunction and suicide behaviors.

Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multi-sample diffusion tensor imaging study

This study uses diffusion tensor imaging and machine learning to predict brain age in schizophrenia and bipolar disorder patients, finding age overestimation in both groups compared to controls.

Dopamine manipulations modulate paranoid social inferences in healthy people.

This study shows that dopamine manipulation affects social inferences related to paranoia in healthy individuals, with haloperidol reducing harmful intent attributions and L-DOPA having context-dependent effects.

Genetic risks of schizophrenia identified in a matched case-control study

The paper validates associations between combinations of dopaminergic gene polymorphisms and schizophrenia risk in a matched case-control study.

Dopamine D1 receptor availability is not associated with delusional ideation measures of psychosis proneness

The study investigates the association between dopamine D1 receptor availability and delusional ideation in healthy controls using PET and questionnaire data, finding little to no linear association.

Aberrant connectivity in auditory precision encoding in schizophrenia spectrum disorder and across the continuum of psychotic-like experiences

This study investigates differences in auditory precision encoding connectivity between schizophrenia spectrum disorder patients, non-psychotic psychiatric inpatients, and healthy controls, finding group-specific and continuum-related connectivity changes.

The influence of Schizotypy on Event-Related Oscillations in Sensory Gating during early Infant Development.

The paper examines whether maternal schizotypy affects sensory gating in 6-month-old infants using auditory stimuli, finding no infant group differences but maternal amplitude reductions in schizotypic mothers.

Reduced intra- and inter-individual diversity of semantic representations in the brains of schizophrenia patients

This study examines semantic representations in schizophrenia patients using fMRI and finds reduced intra- and inter-individual variability compared to healthy controls.

Trajectories of brain volume change over 13 years in chronic schizophrenia.

This study examines brain volume changes in chronic schizophrenia patients and controls over 13 years, finding limited evidence of progressive brain volume loss beyond normal aging.

Translational neurophysiological biomarkers of N-methyl-D-aspartate receptor dysfunction in serine racemase knockout mice

The paper evaluates rodent auditory biomarkers as translational markers for NMDAR dysfunction and supports SRKO mice as a model for PV interneuron dysfunction in schizophrenia.

Impact of second-generation antipsychotics on white matter microstructure in adolescent-onset psychosis.

This study examines how antipsychotic medication affects white matter microstructure in adolescents with early-onset psychosis using MRI and diffusion measures.

Parietal prefrontal feedforward connectivity in association with schizophrenia genetic risk and delusions

The paper examines feedforward parietal-prefrontal connectivity in schizophrenia patients and healthy controls, linking it to delusions and polygenic risk for schizophrenia.

Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population

The paper assesses reinforcement learning deficits in psychosis risk groups and finds they are not linked to schizophrenia polygenic risk in the general population.

Transcriptional profile of pyramidal neurons in chronic schizophrenia reveals lamina-specific dysfunction of neuronal immunity

The paper identifies lamina-specific gene expression changes in pyramidal neurons from schizophrenia patients compared to controls, highlighting immune and synaptic pathway disruptions.

Psychotic-like experiences, polygenic risk scores for schizophrenia and structural properties of the salience, default mode and central-executive networks in healthy participants from UK Biobank

The paper investigates associations between polygenic risk scores for schizophrenia, psychotic-like experiences, and structural brain network properties in healthy UK Biobank participants.

Distinct and shared contributions of diagnosis and symptom domains to cognitive performance in a case-control study of severe mental illness in the Paisa population

The paper investigates how diagnosis and symptom domains affect cognitive performance in a case-control study of severe mental illness, finding distinct cognitive profiles linked to specific symptom domains.

Jumping To Conclusions, General Intelligence, And Psychosis Liability: Findings From The Multi-Centre EU-GEI Case-Control Study

The paper investigates the relationship between jumping to conclusions bias, IQ, psychosis, and polygenic risk scores in a case-control study, finding that IQ significantly predicts JTC bias while schizophrenia PRS does not.

Contrasting effects of chronic lithium, haloperidol and olanzapine exposure on synaptic clusters in the rat prefrontal cortex

This study examines the effects of chronic lithium, haloperidol, and olanzapine on synaptic markers in rat prefrontal cortex, finding lithium increases NLGN clusters while antipsychotics have no effect.

Appraisal of the pleiotropic effects of intelligence and education on schizophrenia: a univariable and multivariable Mendelian randomization study

This study uses Mendelian randomization to explore the pleiotropic effects of education and intelligence on schizophrenia, finding that schooling years increase risk while intelligence decreases it, likely confounded by bipolar disorder.

Overdispersed gene expression characterizes schizophrenic brains

The paper identifies genes and gene sets with increased expression variability in schizophrenia, linking this variability to genetic factors and brain development processes.

Early Treatment Response in First Episode Psychosis: A 7-Tesla Magnetic Resonance Spectroscopic Study of Glutathione and Glutamate

This study links higher brain glutathione levels to faster treatment response in first episode psychosis patients using 7-Tesla MRS.

Subthreshold psychosis symptoms associated with molecular genetic risk in a population-based cohort: Findings from Generation Scotland

This study finds that subthreshold psychosis symptoms in a population-based cohort are associated with genetic risks for schizophrenia, ADHD, autism, and neuroticism, with notable sex differences.

Genetic overlap between psychotic experiences in the community across age and with psychiatric disorders

This study examines genetic correlations between psychotic experiences across age and with psychiatric disorders, finding significant overlaps with schizophrenia and depression.

Assessing auditory processing endophenotypes associated with Schizophrenia in individuals with 22q11.2 Deletion Syndrome

The paper examines auditory processing differences in individuals with 22q11.2 Deletion Syndrome with and without psychotic symptoms compared to neurotypical controls using electrophysiology.

Microstructural white matter and links with subcortical structures in chronic schizophrenia: A free-water imaging approach.

This study uses free-water imaging to find microstructural white matter differences in chronic schizophrenia patients compared to controls, with associations to subcortical structures and clinical symptoms.

Expecting the unexpected: the paranoid style of belief updating across species

The paper investigates belief updating in paranoid individuals and rats exposed to methamphetamine, finding impaired uncertainty-driven learning and rigid anticipation of environmental changes.

Sensory learning and inference is impaired in the non-clinical continuum of psychosis: a replication study

This study replicates findings that sensory learning and inference impairments are linked to psychotic-like experiences in a non-clinical population.

Variations and expression features of CYP2D6 contribute to schizophrenia risk

The paper identifies CYP2D6 variants and expression features linked to schizophrenia risk using RNA-seq, GWAS, and epigenetic data.