Schizophrenia research and treatment

Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by mutation of the psychiatric risk gene Cacna1c

The paper shows that activating neurotrophin receptors with BDNF mimetics can rescue cognitive and synaptic deficits caused by Cacna1c mutations in rats.

MK-801-induced behavioral and dopaminergic responses in the shell part of the nucleus accumbens in adult rats are disrupted after neonatal blockade of the ventral subiculum.

This study examines how neonatal blockade of the ventral subiculum affects MK-801-induced locomotor and dopaminergic responses in adult rats.

Increased random exploration in schizophrenia is associated with inflammation

This study finds that schizophrenia patients show increased random exploration linked to inflammation and disorganization symptoms.

MAP2 is differentially phosphorylated in schizophrenia, altering its function

This study identifies MAP2 phosphorylation changes in schizophrenia, linking them to neuronal structure and synaptic function impairments through phosphoproteomics and transgenic mouse models.

Genetic and clinical analyses of psychosis spectrum symptoms in a large multi-ethnic youth cohort reveal significant link with ADHD.

The paper investigates genetic risk for psychosis spectrum symptoms in youth, finding a significant link with ADHD polygenic scores and age-specific effects.

Associations of psychiatric disease and aging on FKBP5 expression converge on cortical supragranular neurons

The paper investigates how psychiatric disease and aging affect FKBP5 expression in the human brain, identifying supragranular neurons as key targets.

Transcriptome Analysis of Human Induced Excitatory Neurons Supports a Strong Effect of Clozapine on Cholesterol Biosynthesis

The paper investigates the transcriptomic response of induced excitatory neurons to Clozapine, finding significant upregulation of cholesterol metabolism genes.

Function-structure Coupling：White matter fMRI hyper-activation associates with structural integrity reductions in schizophrenia

This study examines the relationship between white matter structural integrity and functional activation in schizophrenia, finding reversed function-structure coupling in frontotemporal tracts.

Role of an atypical cadherin gene, Cdh23 in prepulse inhibition and its implication in schizophrenia

The paper identifies a Cdh23 variant associated with prepulse inhibition and schizophrenia risk in mice and humans.

Modality-specific dysfunctional neural processing of social-abstract and non-social-concrete information in schizophrenia

This study identifies modality-specific neural processing deficits in schizophrenia for social-abstract and non-social-concrete information, but not in bimodal conditions.

The reward-complexity trade-off in schizophrenia

This study examines the reward-complexity trade-off in schizophrenia patients and healthy controls, finding similar empirical trade-off curves but differing policy complexity and bias.

Phenome-wide and Genome-wide Analyses of Quality of Life in Schizophrenia

The paper identifies nine clinical phenotypes and polygenic risk scores associated with quality of life in schizophrenia patients and their relatives.

Cerebellum models of psychosis implicate association nuclei in the pathogenesis of psychosis and mechanisms of cognitive impairment

This study examines white matter changes in schizophrenia patients and finds reduced fractional anisotropy and increased radial diffusivity in specific cerebellar peduncles, linked to disease duration and disrupted cognitive correlations.

Cortico-hippocampal morphology and behavioural indices improved in maternal deprivation model of schizophrenia following vitamin B complex supplementation

This study shows that vitamin B complex supplementation reduces behavioural and histomorphological impairments caused by maternal deprivation in rats.

Patient iPSC-astrocytes show transcriptional and functional dysregulation in schizophrenia

The paper shows that astrocytes from schizophrenia patients exhibit transcriptional and functional changes, including inflammation and synaptic pathway alterations, which are partially reversible with clozapine treatment.

Cell group analysis reveals changes in upper-layer neurons associated with schizophrenia

The paper uses cell-type deconvolution to analyze gene expression in schizophrenia and finds upper-layer neurons in the DLPFC are associated with SCZ risk.

Spatial expression pattern of ZNF391 gene in the brains of patients with schizophrenia, bipolar disorders or major depressive disorder identifies new cross-disorder biotypes: A trans-diagnostic, top-down approach

This paper identifies a common genetic factor across schizophrenia, bipolar disorder, and major depressive disorder using a trans-diagnostic, top-down approach, and links it to ZNF391 expression patterns in the brain that correlate with cognitive and neuroimaging traits.

Electrophysiological correlates of visual backward masking in patients with bipolar disorder

This study examines the neural correlates of visual backward masking in bipolar disorder patients, finding reduced global field power amplitudes similar to schizophrenia.

Developmental Influences on Symptom Expression in Antipsychotic-Naive First-Episode Psychosis

The paper investigates how age affects symptom expression in first-episode psychosis using longitudinal data, finding age-related changes in perceptual and non-perceptual positive symptoms.

Comprehensive gene expression analysis detects global reduction of proteasome subunits in schizophrenia

The paper identifies global down-regulation of proteasome subunits in a subgroup of schizophrenia patients through transcriptome sequencing and pathway analysis across multiple cohorts.

The Mammalian Target of Rapamycin (mTOR) Kinase Mediates Haloperidol-Induced Cataleptic Behavior

This study shows that mTORC1 in the striatum prevents haloperidol-induced catalepsy, suggesting it could be a target for reducing antipsychotic side effects.

The effects of polygenic risk for psychiatric disorders and smoking behaviour on psychotic experiences in UK Biobank

The paper examines how polygenic risk for psychiatric disorders and smoking behavior influence psychotic experiences in UK Biobank participants, finding independent and synergistic effects.

Individual deviations from normative models of brain structure in a large cross-sectional schizophrenia cohort

The paper maps individual deviations from normative brain structure in schizophrenia patients and finds high heterogeneity, with most patients showing infra-normal deviations in at least one region.

Integrative genomic strategies applied to a lymphoblast cell line model reveal specific transcriptomic signatures associated with clozapine response

The paper investigates clozapine's molecular effects using lymphoblastoid cell lines, identifying transcriptomic and epigenomic changes linked to cholesterol and metabolic pathways.

Activation of group II metabotropic receptors attenuates cortical E-I imbalance in a 15q13.3 microdeletion mouse model

The paper shows that activating mGlu2/3 receptors reduces excitatory-inhibitory imbalance in a 15q13.3 microdeletion mouse model, suggesting therapeutic potential for schizophrenia.

Dissimilarity in sulcal width patterns in the cortex can be used to identify patients with schizophrenia with extreme deficits in cognitive performance

The paper identifies a subgroup of schizophrenia patients with extreme cognitive deficits by analyzing sulcal width dissimilarity using the PBSI-SW metric.

Multi-dimensional predictions of psychotic symptoms via machine learning

This study uses machine learning to predict the severity of specific psychotic symptoms from fMRI and behavioural data in schizophrenia patients.

Adolescent-onset and adult-onset schizophrenia: reduced ribosomal protein expression via mTOR signalling in patient-derived olfactory cells

This study compares proteomic profiles of olfactory cells from adolescent- and adult-onset schizophrenia patients, finding similar downregulation of ribosomal proteins and mTOR pathway components.

Do damaging variants of SLC6A9, the gene for the glycine transporter 1 (GlyT-1), protect against schizophrenia?

The paper investigates whether damaging variants in SLC6A9, the gene for GlyT-1, are protective against schizophrenia by analyzing exome data from 4225 cases and 5834 controls.

Influence of prior beliefs on perception in early psychosis: effects of illness stage and hierarchical level of belief

The paper investigates how prior beliefs influence perception in early psychosis, finding differences in reliance on cognitive and perceptual priors between prodromal, psychotic, and control groups.