T-cell and B-cell Immunology

This paper introduces a capture assay to measure single-cell antibody secretion in B cells during plasma cell differentiation.

The paper uses in vivo single-cell gain-of-function screening to identify latent transcriptional programs that reprogram T cells into synthetic states with enhanced therapeutic potential.

The paper identifies Treg clonal expansion and immunosuppressive functions in fibrosis induced by synthetic implants, showing their role in modulating stromal cell behavior.

The paper identifies and classifies rare peripheral CD4+CD8+ double-positive T cells using single-cell RNA sequencing and machine learning, revealing their antigen-experienced features and cytotoxic potential.

This study shows Fezf2 regulates mTEC lineage commitment and homeostasis, with transcriptional repression playing a key role in maintaining thymic epithelial populations.

This study investigates AIM2's role in CD4+ T cell activation and homeostasis, finding it promotes IL-2 production in vitro but not essential for in vivo functions like tumor control.

This study shows that virus-specific CD8 T cells are generated and reactivated in the bone marrow after brain viral infections, leading to changes in the bone marrow niche.

This study shows that imprinted antibody lineages can persist for over 50 years and dominate cross-neutralizing recall responses to poliovirus.

This study shows that activated PI3Kdelta reduces TCF-1+ stem-like CD8+ T cells but promotes effector differentiation and viral control during chronic infection.

The paper shows CD4 T regulatory cells can kill tumor cells through trogocytosis after immunocytokine treatment in a melanoma model.

This study identifies BATF3 as a critical regulator of innate-like γδ T cell homeostasis, function, and tissue distribution, revealing its role in survival, IL-17 production, and immune responses.

This study shows that 4-1BB expression and signaling enhance MAIT cell activation and effector functions through TCR and cytokine signals.

The paper identifies GNG4 as a marker for activated CD4 T follicular helper cells in human germinal centers using multimodal single-cell analysis.

The paper quantifies how V and J gene usage affects CDR3 length and amino acid composition in TCR repertoires and provides a quality control framework for TCR sequencing data.

The paper shows that sparse, random sampling of self peptides in the thymus is sufficient for T cell tolerance to most peripheral self peptides, supported by experimental data and machine learning analysis.

This study identifies a small-molecule inhibitor that selectively disrupts LCK recruitment to CD3ε, reducing TCR activation while preserving other immune responses.

This study identifies Noxa's role in metabolic reprogramming to glutamine dependence in CD8+ T cells, independent of its canonical apoptotic function, and suggests its potential as an immunotherapeutic target.

The paper introduces a falsifiable framework to test neutrality in TCR repertoire databases using a biologically calibrated null model, revealing public clonotype patterns inconsistent with neutral drift.

The paper shows that IgE memory responses are confined to lymphoid organs through GC IL-4 microniches, which are critical for IgE production during allergen recall.

The paper identifies BCL6 and CD4+ T cell dependence in generating functional IgM+ memory B cells independent of germinal center formation.

This study optimizes in vitro expansion of Vδ1+ γδT cells from nonhuman primate PBMCs using CD3 or PHA stimulation with cytokines and phospho-vitamin C, achieving high-fold expansions.

This study shows that Ddx3x is essential for B-cell development in mice, with loss leading to developmental blocks and defects in immunoglobulin rearrangement.

This study identifies the murine dura mater as a transient niche for early-postnatal B lymphopoiesis, highlighting the role of CXCL12-expressing fibroblasts in supporting B cell development.

The paper develops a population dynamics model of B and TFH cells in germinal centers, showing reciprocal stimulation regulates their ratio and balances affinity maturation speed with B cell diversity.

This study identifies a BACH1-cMAF transcriptional axis that drives autoimmunity when SATB1 is lost, showing that targeting this axis can rescue disease.

The paper identifies a conserved set of transcription factors in human CD4+ T cell subtypes and shows subtype-specific rewiring of gene regulatory networks during activation and differentiation.

The paper identifies structural differences in TCR recognition of the same pMHC ligand using cryo-EM, showing how similar β chains can pair with different α chains to produce distinct recognition modes.

This paper develops a minimal energy-landscape model to explain how mechanical force affects T-cell activation by reshaping activation barriers and bond lifetimes through catch-slip dynamics.

This study investigates how intercalated cells interact with immune cells to maintain renal immune homeostasis and contribute to autoimmune kidney disease, identifying an IL-33-mediated Treg interaction.