Alzheimer's disease research and treatments

The paper identifies protein-coding and lncRNA genes associated with Alzheimer's disease pathology through co-expression network analysis of brain RNA-seq data.

This study uses a FDD-KI rat model to show that vascular amyloid deposition, neuroinflammation, and white matter damage contribute to motor dysfunction in Familial Danish Dementia.

The paper identifies citrullination of tau as a novel posttranslational modification in Alzheimer's disease and tauopathy models, showing its association with disease progression.

This study shows that tau aggregation can be reduced by modifying sequences near the PGGG β-turn motif, while maintaining microtubule binding, offering therapeutic insights for neurodegenerative diseases.

This study shows that reducing FMRP and 4E-BP2 in mice prevents memory loss caused by Alzheimer's disease-linked amyloid-beta oligomers.

The paper shows ApoE2 and ApoE3Ch variants protect neurons by removing toxic peroxidated lipids, while ApoE4 worsens lipid-induced damage in rodent models.

This study shows that DAP12 deficiency reduces tau-induced inflammation and myelin loss in mice, despite increased tau pathology, by altering microglia-oligodendrocyte interactions.

This study examines how Tau35 protein affects lysosomal function and autophagy, identifying early pathological changes linked to neurotoxicity in tauopathies.

This study identifies novel post-translational modifications in Alzheimer's disease brains linked to neuropathology and cognition using mass spectrometry data from 101 participants.

The paper identifies age, sex, and disease-dependent lipidomic changes in TgF344-AD rats, showing similarities to human lipid profiles and developing predictive models for AD.

This study develops a single-cell digital twin framework to identify drug targets and repurposable medicines in Alzheimer's disease using single-nuclei RNA-seq and ATAC-seq data.

The paper identifies five therapeutic targets for Alzheimer's disease by integrating phenotypic and proteomic screening in murine microglial cells.

The paper designs synthetic tau fibrils that mimic AD and CTE structures, showing strong seeding ability and catalytic effects in vitro and in cells.

The paper investigates how PP2A regulators LCMT-1 and PME-1 affect sensitivity to tau-induced impairments in models of neurodegenerative diseases.

This study identifies sex-specific gene expression associations with Alzheimer's disease neuropathology and cognitive decline using single-nucleus RNA sequencing from human brain tissue.

This study uses multi-region spatial transcriptomics to identify region-specific transcriptional responses to Aβ plaques in AD, revealing differences in neuronal vulnerability and molecular pathways.

This study shows that transplanting GABAergic interneuron progenitors restores slow oscillation rhythms in Alzheimer's disease mouse models.

This paper investigates the effects of NF-1/CPE gene therapy in AD mice, finding it prevents memory loss and reverses pathology by modulating protein networks involved in synaptogenesis, autophagy, and tau/Aβ accumulation.

This study shows OTULIN regulates tau expression and RNA metabolism in neurons, with implications for Alzheimer's disease and tauopathies.

This study shows that pathological tau expression in the anterodorsal thalamic nucleus disrupts head direction signaling, leading to spatial disorientation in mice.

This study investigates how phosphorylation patterns in the proline-rich region of Tau affect its microtubule-binding dynamics in neurons using FRAP and computational modeling.

The paper uses super-resolution imaging to analyze nanoscale tau aggregates in AD and PART brain tissues, revealing hyperphosphorylation patterns and morphological differences.

The paper uses energetic profiling on cryo-EM data to uncover thermodynamic principles governing amyloid fibril maturation and polymorphic divergence.

This paper shows that glycated amyloid-beta causes mitochondrial dysfunction and Alzheimer's pathology by triggering the cGAS-STING pathway via VDAC1-dependent mtDNA release.

This study shows that Aβ deposition in meningeal arteries correlates with reduced cerebral blood flow and collateral vessel remodeling in a mouse model of AD, with sex differences in Aβ burden.

This study uses single-nucleus multi-omics to identify shared and distinct regulatory pathways in Pick's and Alzheimer's disease, revealing disease-specific enhancers and TF binding patterns.

The paper investigates retinal parameters and spatial memory in 5xFAD mice, finding sex-based differences and correlations between retinal layer thickness and memory performance.

This paper demonstrates that a synNotch receptor can target extracellular Aβ aggregates, enabling the production of AD therapies like Lecanemab and Aducanumab in response to these aggregates.

This study identifies L-fucose as a monosaccharide neuromodulator that enhances synaptic function and mitigates Alzheimer's disease symptoms in mice.