Hearing, Cochlea, Tinnitus, Genetics

Reversal of an existing hearing loss in mutant mice

This study shows that a specific type of hearing loss in mice can be reversed by reactivating the Spns2 gene within a critical period, restoring auditory function and protecting hair cells.

Distorted neural signal dynamics create hypersensitivity to background noise after hearing loss

The paper investigates how hearing loss distorts neural signal dynamics, leading to hypersensitivity to background noise, using brain recordings and deep neural networks.

Human pluripotent stem cells-derived Inner ear organoids recapitulate otic development in vitro.

This study compares human iPSC-derived inner ear organoids with early embryonic inner ear tissue, showing they recapitulate key developmental stages and marker expression.

Stability of neural representations in the auditory midbrain across the lifespan despite age-related brainstem delays

This study shows that age-related delays in the auditory brainstem do not significantly impair complex sound representations in the midbrain of old mice with normal hearing.

Inherent envelope fluctuations in forward masking: Effects of age and hearing loss

The paper investigates how age-related hearing loss affects forward masking in Gaussian noise and finds older listeners with mild hearing loss are more susceptible to masker-envelope fluctuations.

Computational Modeling of the Human Compound Action Potential

This paper develops a computational model to simulate human compound action potentials (CAPs) and shows it captures key features of CAPs elicited by various stimuli.

Apicosome: newly identified cell-type-specific organelle in mouse cochlear and vestibular hair cells

The paper identifies a new organelle, the apicosome, specific to mouse cochlear and vestibular hair cells and describes its developmental dynamics and potential functional roles.

Cortical contributions to the perception of loudness and hyperacusis

This study investigates how changes in parvalbumin-expressing inhibitory interneurons in the auditory cortex affect loudness perception and hyperacusis in mice.

The Hair Cell Analysis Toolbox: A machine learning-based whole cochlea analysis pipeline

The paper introduces HCAT, a machine learning tool for automated analysis of hair cells in cochlear images, enabling fast and unbiased counting, classification, and cochleogram generation.

Modelling homeostatic plasticity in the auditory cortex results in neural signatures of tinnitus

The paper models homeostatic plasticity in an auditory cortex computational model to predict neural signatures of tinnitus and matches human neuroimaging findings.

Experience-dependent flexibility in a molecularly diverse central-to-peripheral auditory feedback system

The paper characterizes olivocochlear neurons during development and after sound exposure, identifying distinct subtypes and their gene expression changes, with a focus on neuropeptide-enriched subtypes that respond to acoustic trauma.

Oncomodulin Regulates Spontaneous Calcium Signaling and Maturation of Afferent Innervation in Cochlear Outer Hair Cells

This study shows that Oncomodulin modulates spontaneous calcium signaling and afferent innervation maturation in cochlear outer hair cells during development.

Spontaneous allelic variant in Ush1g resulting in an expanded phenotype

The paper identifies a spontaneous mutation in the Ush1g gene in Neil1 knockout mice that causes an expanded phenotype including auditory and vestibular defects.

Noise-induced synaptopathy impacts the long and short sensory hair cells differently in the mammalian cochlea

This study shows noise-induced synaptopathy disproportionately affects long and short sensory hair cells in the mammalian cochlea, with distinct spatial patterns of ribbon synapse loss.

Defective mechanosensory transduction of the new inner hair cells prevents hearing recover in the damaged cochlea

This study shows that newly regenerated inner hair cells in the cochlea lack functional mechanosensory transduction, preventing hearing recovery despite successful cell regeneration.

Stochastic Modeling of Tinnitus Loudness

This study models the loudness of chronic tinnitus using harmonic templates and hearing threshold data to quantify tinnitus severity.

Dendritic degeneration and altered synaptic innervation of a central auditory neuron during age-related hearing loss

This study examines age-related changes in dendritic morphology and synaptic innervation of bushy neurons in the cochlear nucleus, finding reduced dendritic complexity and altered synaptic input patterns associated with age-related hearing loss.

Pericytes control vascular stability and auditory spiral ganglion neuron survival

This study shows pericytes support vascular stability and spiral ganglion neuron survival through exosome-mediated VEGF-A signaling, impacting hearing.

Genetic evidence for the link of misophonia with psychiatric disorders and personality

This study identifies genetic correlations between misophonia and psychiatric disorders, showing strong links with anxiety, PTSD, and specific personality traits.

Postsynaptic GluA3 subunits are required for the appropriate assembly of AMPA receptor GluA2 and GluA4 subunits on mammalian cochlear afferent synapses and for presynaptic ribbon modiolar-pillar morphological distinctions

This study shows that GluA3 is essential for the proper assembly of AMPAR subunits and presynaptic ribbon morphology in cochlear synapses, leading to hearing loss in mice.

Reactivation of the progenitor gene Trim71 enhances the mitotic and hair cell-forming potential of cochlear supporting cells

This study shows that reactivating Trim71 enhances the regenerative potential of cochlear supporting cells by promoting de-differentiation and hair cell formation.

Developmental hearing loss-induced perceptual deficits are rescued by cortical expression of GABAB receptors

This study shows that overexpressing GABAB receptors in auditory cortex of gerbils with developmental hearing loss restores perceptual thresholds for temporal and spectral auditory cues.

The role of calcium, Akt and ERK signaling in cadmium-induced hair cell death

This study investigates cadmium-induced hair cell death and finds that calcium signaling, Akt, and ERK pathways behave differently compared to other cell types, with Akt and ERK activation potentially being protective.

Single-Cell Transcriptomic Profiling of the Zebrafish Inner Ear Reveals Molecularly Distinct Hair Cell and Supporting Cell Subtypes

The paper uses single-cell RNA sequencing to analyze zebrafish inner ear cells, identifying distinct hair cell and supporting cell subtypes and their spatial organization.

Bimodal stimulation for the reduction of tinnitus using vibration on the skin

This study demonstrates that bimodal stimulation using a wristband with vibratory motors paired with personalized tones reduces tinnitus symptoms more effectively than tones alone.

Cx26 heterozygous mutations cause hyperacusis-like hearing sensitivity enhancement and increase susceptibility to noise

This study shows that Cx26 heterozygous mutations increase hearing sensitivity and noise susceptibility, challenging the previous view of their harmlessness.

Behavioral assessment of Zwicker tone percepts in rodents

The paper introduces a modified GPIAS paradigm to assess Zwicker tone perception in rodents and finds a significant increase in the GPIAS effect with notched noise, suggesting perception of the Zwicker tone.

Metabolism is correlative not causative for age-related auditory decline in an insect model

The paper investigates whether metabolic decline causes or is correlated with age-related auditory decline in desert locusts, finding it is correlative, not causative.

Piccolino regulates the architecture of the ribbon at cochlear inner hair cell synapses

This study investigates the role of piccolino in cochlear inner hair cell synapses, finding it contributes to active zone organization and is essential for normal synaptic transmission.

Temporal and regulatory dynamics of the inner ear transcriptome during development in mice

This study identifies temporal gene expression patterns and regulatory pathways in mouse inner ear development using bulk RNA-Seq from E11.5 to P7.