Renal Transplantation Outcomes and Treatments

First Order Associations Between Banff Acute Lesions in Kidney Allograft Biopsies and a Urinary Cell Three-Gene Diagnostic Signature

The paper quantifies the direct relationship between Banff acute lesion scores and a urinary cell three-gene signature, showing strong associations with acute rejection pathology.

Non-HLA antibodies worsen the histological phenotype and prognosis of antibody mediated rejection in kidney allografts

This study shows non-HLA antibodies are linked to worse histology and graft outcomes in kidney transplant patients with antibody-mediated rejection, especially when combined with HLA-DSAs.

Beyond eplet counts: machine learning integration of evolutionary distance and electrostatic divergence improves prediction of HLA-DQ donor-specific antibody formation after kidney transplantation

This study improves prediction of HLA-DQ donor-specific antibody formation using machine learning that combines eplet counts with genetic and electrostatic distance metrics, achieving higher accuracy than existing methods.

Voclosporin Preserves Mitochondrial Function Compared With Cyclosporine A in Perfused Human Proximal Tubule Microphysiological Systems

This study compares voclosporin and cyclosporine A in 3D kidney MPS, finding that voclosporin preserves mitochondrial function and reduces proteostatic stress compared to cyclosporine A.

Autoreactive antibody production by intrarenal B cells in mouse kidney allograft rejection

This study shows that autoreactive B cells in rejecting kidney allografts produce pathogenic IgG independently of donor-specific antibodies, highlighting a novel mechanism in antibody-mediated rejection.

Not all alloantibodies are created equal: IgG glycosylation and severity of antibody-mediated rejection in kidney transplantation

This study examines the link between IgG glycosylation profiles and the severity of antibody-mediated rejection in kidney transplant recipients, finding higher bisecting GlcNAc levels correlate with more severe rejection outcomes.

Spatially Resolved Banff Tubulitis and Glomerulitis Scoring in Kidney Allograft Biopsies via Artificial Intelligent-Based Structure Segmentation and Spatial Transcriptomics

The paper develops an AI-based method to generate spatial Banff t- and g-scores using spatial transcriptomics and histology, showing full concordance in severe rejection cases.

Pre-transplant TCR Network Topology Predicts Kidney Allograft Rejection Independent of HLA Mismatch

This study uses TCR network topology from pre-transplant PBMCs to predict kidney graft rejection, achieving high accuracy independent of HLA mismatch.

Rapid liquid biopsy assessment through gene profiling from the kidney biopsy transport medium: a technical validation and a proof-of-concept pilot study

This study validates the use of kidney biopsy transport medium for rapid gene profiling to enable same-day molecular diagnosis of kidney disease.

Co-Stimulatory Blockade Prevents Intragraft Accrual of Class-Switched, Activated B Cells Despite Failing to Prevent T-Cell Mediated Rejection

The paper investigates the effects of co-stimulatory blockade on B cell accrual and T cell subsets during T-cell-mediated renal allograft rejection using single-cell RNA sequencing.

Calcineurin inhibition deactivates pyruvate dehydrogenase and induces proximal tubule cell metabolic dysfunction, causing profibrotic phenotype

The paper shows that calcineurin inhibition deactivates pyruvate dehydrogenase, leading to proximal tubule cell metabolic dysfunction and kidney fibrosis.

A T-cell Intrinsic Role for APOL1 Risk Alleles in Allograft Rejection

This study identifies a T-cell intrinsic mechanism by which APOL1 risk alleles contribute to kidney rejection through altered calcium signaling and T-cell activation.

Inhibition of De Novo Autoantibody Production Attenuates Chronic Antibody-Mediated Rejection of Kidney Allografts Despite Maintenance of High Donor-Specific Antibody Titers

The paper shows that inhibiting de novo autoantibody production reduces chronic antibody-mediated rejection of kidney allografts, even when donor-specific antibody titers remain high.

Spatial Transcriptomics Using Archived Formalin-Fixed Paraffin-Embedded Core Needle Biopsy Tissues Revealed Unique Transcriptomic Signatures in Kidney Transplant Rejections

This study uses spatial transcriptomics on FFPE kidney biopsy tissues to identify distinct transcriptomic signatures for different types of kidney transplant rejections.

Genetic polymorphisms of Leukocyte Immunoglobulin-Like Receptor B3 (LILRB3) gene in African American kidney transplant recipients are associated with post-transplant graft failure

The paper identifies four SNPs in the LILRB3 gene associated with graft failure in African American kidney transplant recipients and links them to immune-related diseases.

Unveiling APOL1 Haplotypes: A Novel Classification Through Probe-Independent Quantitative Real-Time PCR

This study develops a probe-independent qPCR method to identify APOL1 variants in kidney transplant recipients and assesses their impact on transplant outcomes.

Multiscale genetic architecture of donor-recipient differences reveals intronic LIMS1 locus mismatches associated with long-term renal transplant survival

Mismatches in gene deletions and kidney-related proteins are novel histocompatibility factors in kidney transplantation

This study identifies mismatches in gene deletions and kidney-related proteins as novel histocompatibility factors associated with acute rejection in kidney transplantation.

Detection of infiltrating fibroblasts by single-cell transcriptomics in human kidney allografts

This study uses scRNA-seq to analyze kidney allograft biopsies and identifies recipient-derived fibroblasts and other cell states associated with fibrosis and rejection.

Proteomics Reveals Extracellular Matrix Injury in the Glomeruli and Tubulointerstitium of Kidney Allografts with Early Antibody-Mediated Rejection

The paper uses proteomics to identify ECM injury in kidney allografts with early AMR, finding decreased ECM proteins and increased LGALS1 and GSTO1 in affected tissues.

Harnessing Expressed Single Nucleotide Variation and Single Cell RNA Sequencing to Define Immune Cell Chimerism in the Rejecting Kidney Transplant

The paper uses exome sequencing and scRNA-seq to identify donor and recipient immune cells in kidney transplants and finds distinct transcriptional profiles in donor macrophages and T cells.

Precision Sub-phenotyping of Histologically Stable Kidney Transplants by a Composite Molecular and Cellular Instability Score

The paper develops a molecular and cellular instability score to reclassify histologically stable kidney allografts, identifying those with molecular signatures of acute rejection and predicting clinical outcomes.

Association study of long-term kidney transplant rejection using whole-exome sequencing

This study used whole-exome sequencing to investigate genetic factors associated with long-term kidney transplant rejection but found no statistically significant associations.

Mapping molecular HLA typing data to UNOS antigen equivalents for improved virtual crossmatch

The paper creates a UNOS antigen equivalency table for HLA alleles and develops tools to map molecular HLA typing data to antigen equivalents for virtual crossmatch.