Nutrition and Health in Aging

Wasting is essential: cachexia is driven by a wound-healing adaptation

This paper develops a mathematical model showing that induced muscle wasting (IMW) supports wound healing and that inhibiting IMW can prevent cachexia and restore muscle mass with nutritional support.

Voluntary wheel running selectively preserves skeletal muscle during pancreatic cancer cachexia despite persistent systemic alterations

This study compares voluntary wheel running and treadmill running in a pancreatic cancer model, finding that VWR preserves skeletal muscle while TR does not, despite similar systemic effects.

Cancer cachexia overrides sex-specific traits in Drosophila

This study shows that cancer cachexia in Drosophila reduces sex-specific differences in gene expression and metabolic profiles, leading to a shared molecular cachexic state.

Engaging the host adaptive response to nutrient limitation delays cancer cachexia

This study shows that caloric restriction before tumor induction delays cancer cachexia by reducing systemic inflammation and preserving lean mass.

The heterogeneity of age-related muscle atrophy of lower limb muscles

This study quantifies age-related differences in lower limb muscle volume across 17 muscles in young and older adults, revealing significant heterogeneity in atrophy patterns.

Chemotherapy induces tissue NAD+ loss, and downregulation of NAD+ biosynthetic enzyme Nrk2 marks muscle wasting

This study shows chemotherapy causes NAD+ loss in muscle and liver, with Nrk2 downregulation linked to muscle wasting across multiple models.

Combined AMPK activation and ghrelin ameliorate cancer cachexia through complementary effects on energy homeostasis, inflammation, and wasting

This study shows that combining AMPK activation with ghrelin improves cachexia by enhancing energy balance, reducing inflammation, and preventing muscle and fat loss.

Plasma proteomics identifies an IL-6 -associated SAA axis linked to muscle wasting and survival in patients with cancer cachexia

The paper identifies an IL-6-associated SAA axis linked to muscle wasting and poor survival in cancer cachexia through plasma proteomics and functional studies.

Decreased food intake contributes to elevated insulin-responsiveness in pre-clinical cancer cachexia

This study shows that reduced food intake in cancer cachexia increases skeletal muscle insulin responsiveness through AKT signaling, independent of tumor presence.

Tumor-Derived Polyamines Initiate Fat Wasting in Cancer Cachexia

This study identifies polyamine-dependent tumor-adipose crosstalk as an early driver of fat wasting in cancer cachexia, linking polyamine metabolism to adipocyte lipolysis and poor patient survival.

Proteomic and phospho-proteomic longitudinal signatures of human skeletal muscle in lung cancer cachexia

The paper identifies proteomic and phosphoproteomic changes in skeletal muscle of lung cancer patients with cachexia, linking them to muscle wasting and signaling pathways.

JAK1/2 Inhibition Delays Cachexia and Improves Survival through Increased Food Intake

This study shows that JAK1/2 inhibition with ruxolitinib improves survival and body weight in lung cancer models by increasing food intake and restoring metabolic function.

Targeting the amino acid metabolism in Lung Sarcopenia: A Systems Engineering Approach

This paper develops a mathematical model to explore how IL-6 signaling disrupts BCAA metabolism and redox homeostasis, contributing to NSCLC-induced sarcopenia.

Identification of mitochondria and macrophage activation related hub genes in sarcopenia

The paper identifies hub genes related to sarcopenia progression linked to mitochondria and macrophage activation using GEO datasets and pathway analysis.

Pancreatic cancer cachexia is mediated by PTHrP-driven disruption of adipose de novo lipogenesis

This study identifies PTHrP as a driver of pancreatic cancer cachexia by suppressing adipose de novo lipogenesis, showing that blocking PTHrP-PTH1R signaling reduces wasting in mouse models.

Sustained Glucose Turnover Flux Distinguishes Cancer Cachexia from Nutrient Limitation

This study identifies sustained glucose turnover flux as a distinguishing metabolic feature of cancer cachexia compared to nutrient limitation under controlled food intake.

Separating anorexia -dependent and -independent effects in cancer cachexia

This study investigates the extent to which anorexia contributes to different cachectic phenotypes in cancer cachexia using a preclinical model.

A genome wide association study to identify germline variants associated with cancer-associated cachexia - a preliminary analysis

This study conducts a GWAS to identify germline CNVs associated with weight loss in cancer cachexia, finding enriched pathways and overlapping genes with skeletal muscle expression.