Ion channel regulation and function

The paper investigates axonal conduction reliability in sympathetic preganglionic neurons, showing it is modifiable and regulated by ion channels and receptors.

The paper investigates how hERG blockers like nifekalant can increase K+ channel current through an agonism-while-blocking mechanism, potentially explaining their safety profile.

This study investigates how cholesterol, PtdIns(4,5)P2, and actin regulate BK channel nanoscale organization using super-resolution imaging and FRAP in heterologous and endogenous systems.

This study uses an intersectional CRISPR-Cas9 approach to target NaV1.1 in proprioceptors, revealing its essential role in motor coordination and action potential firing.

This study examines the role of helix O alanine residues in CLC channels, showing that mutations at these sites cause proteostatic defects and impair channel function.

This paper uses hiPSC-derived sympathetic neurons to study pathways regulating neuronal excitability and finds that GIRK channels mediate inhibitory effects of adrenergic and muscarinic receptors.

This study examines the biophysical effects of a Cav2.3 channel mutation (L228P) linked to DEEs using whole-cell patch-clamp, finding a shift in voltage-dependent activation and inactivation towards hyperpolarized potentials.

This paper genetically engineers K2P channels to be activated by rapamycin or its analogs, enabling chemogenetic control of cellular membrane potential.

The paper analyzes the evolutionary history and embryonic expression of KCNH voltage-gated potassium channels in zebrafish, revealing their origins in invertebrates and expanded gene numbers in vertebrates.

This paper develops a unified ensemble-allosteric framework to explain how gain- and loss-of-function mutations in IP3R1 cause disease by altering conformational dynamics and allosteric communication.

This study identifies MLO proteins as trimeric inward calcium channels, revealing their structural and functional mechanisms for calcium influx in plants.

This paper derives analytic current-voltage-concentration relations for narrow cylindrical domains using cross-diffusion equations, showing how ion influx affects voltage and other ions' concentrations.

The paper identifies the down-to-up state transition as the primary activation pathway for TREK K2P channels, showing it does not involve lipid occlusion of the pore.

The paper characterizes a CACNA1A variant in a patient with mixed clinical symptoms, showing conflicting in vitro and in vivo effects that highlight the importance of cellular context.

This study investigates the gating mechanism of MthK channels using mutants, revealing hydrophobic and lipid-mediated processes that drive channel closure.

This study shows that calcium-dependent facilitation of P/Q-type calcium channels controls the polarity and magnitude of short-term synaptic plasticity in fast-spiking synapses.

This study identifies dibenzoylmethane (DBM) as a novel inhibitor of BKCa channels, showing it blocks the pore and alters ion dynamics, with structural features critical for activity.

This study uses AI-based structural modeling to predict and compare closed-state conformations of the hERG channel, revealing insights into its dynamics and potential drug interactions.

The paper investigates the role of CaV2.1 calcium-dependent facilitation in auditory synaptic transmission, finding that its absence reduces synaptic reliability and precision.

This study uses cryo-EM and solid-state NMR to determine the structure and dynamics of MscL from E. coli, revealing lipid-protein interactions that drive mechanosensitive gating.

This study identifies how CatSper channels integrate temperature and pH signals through structural and evolutionary analyses in sperm.

This study uses molecular dynamics simulations to show that LQT2 mutations disrupt the selectivity filter structure, impairing channel trafficking, and that some variants can correct these defects.

This study identifies LRRC55 as an auxiliary subunit of BK channels in Purkinje cells, showing its role in motor coordination and synaptic plasticity through BK channel modulation.

This study characterizes the structure and function of MscM, revealing that its cytoplasmic domain mediates channel gating through conformational changes, differing from other MscS-like channels.

The paper identifies SK2/3 channels coupled with T-type Ca2+ channels as a mechanism gating spinal locomotor rhythm generation, showing their role in initiating and terminating locomotor activity.

This study functionally classifies HCN1 variants in patients with neurodevelopmental disorders, finding genotype-phenotype correlations and potential therapeutic targets.

The paper examines the co-expression patterns of voltage-gated sodium channel subunits in neurons across different brain regions and developmental stages, revealing distinct subunit combinations in inhibitory and excitatory neurons.

This study investigates how ion channels contribute to non-linear firing dynamics in postnatal mouse spinal motoneurons, showing that PICs and other channels like KCNQ, Kv1.2, and HCN play key roles in sustaining firing.

This paper discovers a small-molecule inhibitor of KCa3.1 channels by combining molecular dynamics simulations and high-throughput screening.