Cardiovascular Function and Risk Factors

Relative contributions of correcting the diet and voluntary exercise to myocardial recovery in a two-hit murine model of heart failure with preserved ejection fraction.

This study evaluates the relative effects of diet correction and voluntary exercise on myocardial recovery in a murine HFpEF model, revealing sex-specific responses and residual anomalies in males.

Speckle-tracking echocardiography in preclinical mouse models: Implications for cancer therapy-related cardiac dysfunction from inhibition of the extracellular signal-regulated kinase 1/2 (ERK1/2) cascade

This paper evaluates speckle-tracking echocardiography in mice to assess cardiac function and drug effects, finding it more sensitive than traditional methods in detecting regional changes.

Old mice have a functionally distinct contractile reserve from obese mice

This study uses speckle tracking echocardiography to compare contractile reserve in old and obese mice, finding distinct functional phenotypes in their cardiac responses to preload and sympathetic stimulation.

Targeting C42 in PKGIα alleviates diastolic dysfunction in HFpEF

This study shows that targeting C42 in PKGI with urolithin A reduces diastolic dysfunction and cardiac remodeling in a mouse model of HFpEF and improves heart tissue function in humans.

A New Model of Heart Failure with Preserved Ejection Fraction Induced by Metabolic Syndrome in Ossabaw Miniature Swine

This paper develops a new animal model of heart failure with preserved ejection fraction induced by metabolic syndrome in Ossabaw miniature swine, replicating key human disease features.

Establishing Comprehensive Transthoracic Echocardiography Reference Ranges for Mouse Models: Insights into the Impact of Anesthesia, Sex, and Age

This study establishes TTE reference ranges for mice, showing anesthesia significantly affects cardiac function, with minimal sex differences and modest age-related changes.

Salt-inducible kinase inhibition promotes weight loss and improves the diastolic function of obesity-related heart failure with preserved ejection fraction in mice

This study shows that inhibiting salt-inducible kinases (SIKs) reduces weight gain and improves diastolic heart function in obese mice with heart failure with preserved ejection fraction (HFpEF).

Neutrophil arrest in myocardial capillaries drives hypoxia and impairs diastolic function in a mouse model of heart failure with preserved ejection fraction

This study identifies neutrophil arrest in myocardial capillaries as a driver of hypoxia and impaired diastolic function in a mouse model of HFpEF, showing that reducing neutrophil arrest improves cardiac function.

Optimized protocols for commonly-used murine models of heart failure with preserved ejection fraction.

This paper optimizes two murine models of heart failure with preserved ejection fraction (HFpEF) to improve reproducibility and robustness across strains and sexes.

Left Atrial Strain as a Predictor of Cardiac Dysfunction in a Murine Model of Pressure Overload

This study shows that left atrial strain predicts cardiac dysfunction in a mouse model of pressure overload, with early detection before changes in volume or ejection fraction.

Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension

This paper develops a two-hit mouse model of HFpEF combining diet-induced obesity and renin-mediated hypertension, showing key features of the disease and response to therapy.

Sex-Specific Changes in Cardiac Function and Electrophysiology During Progression of Adenine-Induced Chronic Kidney Disease in Mice

This study examines sex-specific cardiac changes in a mouse model of CKD-induced CVD, finding males show more severe LV dysfunction and altered ECG markers than females.

Integrated systems biology identifies disruptions in mitochondrial function and metabolism as key contributors to heart failure with preserved ejection fraction (HFpEF)

The paper uses systems biology to identify mitochondrial dysfunction and metabolic disruptions as key factors in HFpEF using a rat model.

Afterload-induced Decreases in Fatty Acid Oxidation Develop Independently of Increased Glucose Utilization

This study shows that reduced glucose utilization in heart failure with preserved ejection fraction does not lead to increased fatty acid oxidation, even when glucose availability is limited.

In-silico heart model phantom to validate cardiac strain imaging

This paper introduces an in-silico heart phantom to validate cardiac strain imaging algorithms by simulating 4D cardiac motion and testing strain quantification accuracy.

Comparative Analysis of Housing Temperature Impact on Heart Failure with Preserved Ejection Fraction in J vs N Strain C57BL/6 Mice

This study examines how mouse strain and housing temperature affect metabolic syndrome and HFpEF development in a two-hit model, finding strain-specific responses to thermoneutral conditions.

ATP-dependent citrate lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling of the Heart

This study shows that ACL loss in the heart increases glucose oxidation and reduces citrate efflux, leading to metabolic remodeling and cardiac dysfunction.

Modulating Cardiac Energetics in Cardio-Metabolic Syndromes: A mechanistic, hyperpolarized MR Trial of Ninerafaxstat Treatment

This paper evaluates the effects of ninerafaxstat on cardiac energetics and function in patients with cardio-metabolic syndromes using hyperpolarized MR and metabolomics.

DeepStrain: A Deep Learning Workflow for the Automated Characterization of Cardiac Mechanics

This paper develops a deep learning workflow to automatically analyze cardiac mechanics from cine-MRI data, showing high accuracy and reliability in strain and strain rate measurements.