Heat shock proteins research

Dicarboxylic acids synergize with yeast and human Hsp60/10 systems to mimic GroEL/ES

The paper shows that eukaryotic Hsp60/10 systems with dicarboxylic acids mimic GroEL/ES activity in vitro, altering the folding landscape specifically for eukaryotic chaperonins.

Interactome dynamics during heat stress signal transmission and reception

The paper uses qXL-MS to study interactome changes during heat stress, finding RNA-binding proteins show significant interactome shifts, suggesting RNA acts as a temperature sensor.

Proteostatic remodeling of small heat shock chaperones - crystallins by Ran-binding protein 2 and the peptidyl-prolyl cis-trans isomerase and chaperone activities of its cyclophilin domain.

This study identifies the role of Ranbp2's cyclophilin domain in regulating crystallin proteostasis and neuroprotection in the chorioretina through proteomic analysis of genetically modified mice.

Single-cell expression predicts neuron specific proteinhomeostasis networks

The paper uses single-cell expression data to analyze protein homeostasis networks in the human brain, revealing specialized networks in different cell types and their links to neuronal function.

In silico characterization, homology modeling and structure-based functional annotation of Nile Tilapia (Oreochromis niloticus) Hsp70 and Hsc70 proteins

The paper characterizes Nile tilapia Hsp70 and Hsc70 proteins through in silico analysis, homology modeling, and functional annotation, revealing structural and functional insights.

The ribosome-associated chaperone Zuo1 controls translation upon TORC1 inhibition

The paper shows that Zuo1, an Hsp40 cochaperone, is required for translational control and proteostasis maintenance in yeast under TORC1 inhibition.

Transcriptional Responses of Cancer Cells to Heat Shock-Inducing Stimuli Involve Amplification of Robust HSF1 Binding

The paper investigates how HSF1 binding patterns remain consistent across different heat shock stimuli in cancer cells and links these patterns to transcription outcomes and chromatin accessibility changes.

Effects of HSP70 chaperones Ssa1 and Ssa2 on Ste5 scaffold and the mating mitogen-activated protein kinase (MAPK) Pathway in Saccharomyces cerevisiae

The paper investigates the role of HSP70 chaperones Ssa1 and Ssa2 in Ste5 scaffold function and mating pathway activation in yeast.

AP profiling resolves co-translational folding pathway and chaperone interactions in vivo

The paper develops AP profiling to study co-translational folding and chaperone interactions in live cells, revealing how topology influences folding pathways and chaperone function.

Competition co-immunoprecipitation reveals interactors of the chloroplast CPN60 chaperonin machinery

The paper identifies new substrates of the chloroplast CPN60 chaperonin machinery using competition co-immunoprecipitation and mass spectrometry in Chlamydomonas reinhardtii.

Exploring the interaction of inhibitor YM-1 with Plasmodium falciparum HSP70s through in silico methods

This study uses in silico methods to analyze the binding of YM-1 to Plasmodium falciparum HSP70s, finding stronger interaction with the mitochondrial homolog.

Data-driven large-scale genomic analysis reveals an intricate phylogenetic and functional landscape in J-domain proteins

The paper uses ANNs to classify J-domain proteins, revealing phylogeny, localization, and domain composition from sequence data, with insights into coevolution with Hsp70 partners.

Interplay between Nrf2 and αB-crystallin in the lens and heart of zebrafish under proteostatic stress

The paper investigates the interaction between Nrf2 and αB-crystallin in zebrafish lens and heart under proteostatic stress, revealing transcriptional changes and phenotypic consequences.

Analyzing interaction of rhodacyanine inhibitor MKT-077 with Plasmodium falciparum HSP70 nucleotide binding domains

The paper uses bioinformatics tools to analyze interactions between MKT-077 and Plasmodium falciparum HSP70s, identifying hydrophobic interactions and binding residues.

Understanding the structural basis for differential binding of lapachol with PfHSP70s

The paper investigates why lapachol inhibits PfHSP70-x more effectively than PfHSP70-1 using molecular docking and identifies key amino acid residues involved in binding.

Inter individual variability in neuronal expression of heat shock protein genes predicts stress survival in Caenorhabditis elegans.

The paper identifies inter-individual variability in neuronal heat shock protein gene expression as a predictor of stress survival in C. elegans.

The Crystal Structure of the Hsp90-LA1011 Complex and the Mechanism by which LA1011 may Improve the Prognosis of Alzheimer's Disease.

The paper presents the crystal structure of the Hsp90-LA1011 complex and suggests LA1011 may improve Alzheimer's disease prognosis by disrupting FKBP51 binding to Hsp90.

Functional analysis of a common BAG3 allele associated with protection from heart failure

This study investigates the functional impact of a BAG3 allele associated with reduced heart failure risk, showing it enhances cardiomyocyte stress resistance through altered protein interactions.

Genetic inactivation of essential HSF1 reveals an isolated transcriptional stress response selectively induced by protein misfolding

The paper genetically inactivates HSF1 in yeast to show it uniquely senses protein misfolding and triggers a specific transcriptional stress response, distinct from heat shock.

Dynamics and composition of small heat shock protein condensates and aggregates

This study investigates how varying ratios of HspB2 and HspB3 affect their phase behavior, revealing reversible condensates and aggregates with distinct molecular compositions.

Meta-analysis of heat-stressed transcriptomes using the public gene expression database from human and mouse samples

The paper performs a meta-analysis of heat-stressed transcriptomes from human and mouse samples to identify common upregulated and downregulated genes.

Bioinformatic identification of ClpI, a distinct class of Clp unfoldases in Actinomycetota

The paper identifies ClpI, a new class of Clp unfoldases in Actinomycetota, distinct from ClpB and ClpC, with unique structural and functional features.

The Escherichia coli small heat shock protein IbpA plays a role in regulating the heat shock response by controlling the translation of σ32

The paper identifies IbpA as a regulator of the heat shock response in E. coli by suppressing σ32 translation, contributing to the shutdown of the response.

Characterizing Primary transcriptional responses to short term heat shock in paired fraternal lymphoblastoid lines with and without Down syndrome.

The paper investigates the heat shock response in lymphoblastoid cell lines with and without trisomy 21, finding a more robust response in trisomy 21 cells.

AlphaFold predicted structure of the Hsp90-like domains of the neurodegeneration linked protein sacsin reveals key residues for ATPase activity

The paper uses AlphaFold to predict the structure of sacsin's Hsp90-like domains and identifies key residues for ATPase activity, suggesting sacsin functions as an ATP-driven molecular chaperone.

Identification of subfunctionalized aggregate-remodeling J-domain proteins in plants

The paper identifies subfunctionalized J-domain proteins in Arabidopsis thaliana that remodel protein aggregates, showing distinct stress responses and interactions with Hsp101.

Distinct chaperonopathy in skeletal muscle associated with the dominant variant in DNAJB4

The paper identifies a DNAJB4 variant causing chaperonopathy in skeletal muscle, leading to muscle weakness and specific pathological features in type 1 fibers.

Structural and dynamical basis for the interaction of HSP70-EEVD with JDP Sis1

This study uses NMR to show that the EEVD motif of HSP70 transiently binds multiple sites on Sis1, facilitating HSP70 interaction and client protein release.

Translational reprogramming in response to accumulating stressors ensures critical threshold levels of Hsp90 for mammalian life

The paper shows that mammalian cells can maintain critical Hsp90 levels through translational reprogramming in response to stress, ensuring viability despite genetic loss of Hsp90 alleles.

Genome-wide identification and characterization of the HSP gene superfamily in apple snails (Gastropoda: Ampullariidae) and expression analysis under temperature stress

The paper identifies and characterizes HSP gene superfamily members in apple snails and analyzes their expression under temperature stress.