Sleep and Wakefulness Research

Targeted memory reactivation of a serial reaction time task in SWS, but not REM, preferentially benefits the non-dominant hand

This study shows that targeted memory reactivation during slow-wave sleep improves performance in a serial reaction time task, particularly for the non-dominant hand, while REM sleep does not provide similar benefits.

Astroglial Calcium Signaling Encodes Sleep Need in Drosophila

The paper shows that astroglial calcium signaling in Drosophila increases with sleep need and is required for homeostatic sleep rebound, identifying TyrRII as a key receptor involved in this process.

Neurovascular coupling and bilateral connectivity during NREM and REM sleep

This study examines how cerebral hemodynamics change during different sleep states in mice, finding that hemodynamic responses during NREM and REM sleep are significantly larger than those evoked by sensory stimulation.

Sleep spindles coordinate corticostriatal reactivations during the emergence of automaticity

The paper shows that sleep spindles during NREM sleep mediate corticostriatal plasticity, which is critical for the emergence of automatic behavior following training.

Differential gene expression in brain and liver tissue of Wistar rats after rapid eye movement sleep deprivation

This study uses microarray analysis to identify differentially expressed genes in brain and liver tissues of rats after 9 days of REM sleep deprivation, finding distinct gene impacts in each tissue.

Hypothalamic NMDA receptors stabilize NREM sleep and are essential for REM sleep

This study shows that NMDA receptors in the hypothalamus are critical for stabilizing NREM sleep and enabling REM sleep by regulating calcium signals and neural activity.

Losing Control: Sleep Deprivation Impairs the Suppression of Unwanted Thoughts

This study shows that sleep deprivation impairs the ability to suppress unwanted memories, leading to increased negative affect and potentially contributing to psychiatric conditions.

Influences of time of day on generalization

This study investigates how time of day affects generalization ability, finding better performance in the morning than the evening, with no benefit from sleep.

Selective REM-Sleep Suppression Increases Next-Day Negative Affect and Amygdala Responses to Social Exclusion

This study shows that suppressing REM sleep increases negative affect and amygdala responses to social exclusion the next day, but not emotional regulation through reappraisal.

Insulin-Like Growth Factor I Modulates Sleep Through Hypothalamic Orexin Neurons

This study shows that IGF-I modulates sleep by regulating orexin neurons in the hypothalamus, affecting sleep architecture and electrocorticographic patterns in mice.

GABA-Glutamate supramammillary neurons control theta and gamma oscillations in the dentate gyrus during paradoxical (REM) sleep

The paper identifies SuML-DG neurons that modulate theta and gamma oscillations in the dentate gyrus during REM sleep and other vigilance states.

A conserved role for sleep in supporting spatial learning in Drosophila

This study shows that sleep supports spatial learning in Drosophila, with sleep loss and aging impairing learning, which can be reversed by enhancing sleep.

Probing Causality of the Brainstem-Hypothalamic Murine Models of Sleep-Wake Regulation

The paper examines sleep-wake regulatory nuclei in rats using long-term single- and multi-unit recordings, finding differences in activity profiles compared to previous studies when correlated with cortical and behavioral data.

AANAT1 functions in astrocytes to regulate sleep homeostasis.

This study identifies AANAT1's role in astrocytes to regulate sleep homeostasis by modulating monoamine levels and rebound sleep after deprivation in Drosophila.

Unraveling Why We Sleep: Quantitative Analysis Reveals Abrupt Transition from Neural Reorganization to Repair in Early Development

The paper quantitatively distinguishes sleep functions in development, showing an abrupt transition from neural reorganization to repair between 2-3 years in humans.

Hypothalamic circuitry underlying stress-induced insomnia and peripheral immunosuppression

This study identifies hypothalamic circuitry involved in stress-induced insomnia and immunosuppression using genetic and optogenetic approaches.

Interaction of Hippocampal Ripples and Cortical Slow Waves Leads to Coordinated Large-Scale Sleep Rhythm

This study examines the interaction between cortical slow oscillations and hippocampal ripples during sleep using a computational model and human recordings, finding that ripples influence cortical spatiotemporal patterns and synchronize state transitions.

Fast and slow cortical high frequency oscillations for cortico-cortical and cortico-hippocampal network consolidation during NonREM sleep

The paper investigates high frequency oscillations during NonREM sleep, finding that fast oscillations are associated with memory consolidation after learning, while slow oscillations are not.

An essential role for MEF2C in the cortical response to loss of sleep

This study identifies MEF2C as essential for the biological responses to sleep loss, including gene expression changes and synaptic strength recovery.

Sleep-dependent offline performance gain in visual perceptual learning is consistent with a learning-dependent model

This study shows that sleep-dependent gains in visual perceptual learning are better explained by a learning-dependent model than a use-dependent model.

Can sleep protect memories from catastrophic forgetting?

This study shows that sleep replay helps protect old memories from being lost when new memories are learned, by reorganizing synaptic connections to support both memories.

Sleep loss disrupts hippocampal memory consolidation via an acetylcholine- and somatostatin interneuron-mediated inhibitory gate

The paper shows sleep loss disrupts hippocampal memory consolidation by activating somatostatin interneurons and cholinergic inputs, which inhibit memory-related activity.

Estradiol Action at the Median Preoptic Nucleus is Necessary and Sufficient for Sleep Suppression in Female Rats

An Electrophysiological Marker of Arousal Level in Humans

The paper identifies the 1/f spectral slope as an electrophysiological marker that distinguishes wakefulness from sleep and anesthesia by reflecting changes in excitation-inhibition balance.

Learning and Sleep Have Divergent Effects on Cytosolic and Membrane-Associated Ribosomal mRNA Profiles in Hippocampal Neurons

The paper examines how learning and sleep affect ribosomal mRNA profiles in hippocampal neurons, finding that sleep loss disrupts post-learning transcript changes more in active neurons.

Sleep spindles mediate hippocampal-neocortical coupling during sharp-wave ripples

The paper investigates how sleep spindles facilitate hippocampal-neocortical communication during sharp-wave ripples, showing increased coupling and directional influence from neocortex to hippocampus.

A single nucleotide polymorphism in the HOMER1 gene is associated with sleep latency and theta power in sleep electroencephalogram

The paper identifies a SNP in the HOMER1 gene associated with sleep latency and theta power in sleep EEG in a Brazilian population.

Sleep Identification Enabled by Supervised Training Algorithms (SIESTA): An open-source platform for automatic sleep staging of rodent polysomnographic data

SIESTA automates sleep staging in rodents using machine learning, achieving high F1 scores for wakefulness, REM, and NREM sleep stages.

Circadian Rhythms of Perineuronal Net Composition

The paper investigates circadian rhythms of perineuronal nets (PNNs) in rodents and humans, showing diurnal and circadian variations and disruption by sleep deprivation.

Sleep deprivation triggers somatostatin neurons in prefrontal cortex to initiate nesting and sleep via the preoptic and lateral hypothalamus

The paper identifies a circuit pathway in mice where sleep-deprived prefrontal cortex neurons trigger nesting and sleep via connections to the preoptic and hypothalamus.