Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Sex differences in gene expression and proliferation are dependent on the epigenetic modifier HP1γ

The paper shows that HP1γ regulates sex differences in gene expression and proliferation in male and female mice by affecting autosomal gene expression.

Sex-specific co-expression networks and sex-biased gene expression in the salmonid Brook Charr Salvelinus fontinalis

The paper characterizes sex-specific co-expression networks and sex-biased gene expression in Brook Charr, identifying modules associated with growth, reproduction, and stress, and finding more transcripts in female networks with higher variation.

The mir-35 family links maternal germline sex to embryonic viability in C. elegans

This study shows that the mir-35 family of microRNAs in C. elegans is essential for embryonic viability and links maternal germline sex determination to embryonic lethality.

Dosage sensitivity of X-linked genes in human embryonic single cells

The paper reanalyzes single-cell RNA-seq data to show X-linked genes are not upregulated in male human embryos and their expression ratio decreases, contradicting Ohno's hypothesis.

Interactions between dosage compensation complex components Msl-1, Msl-2 and NURF component NURF301 with long non-coding RNA gene hsrω

This study identifies interactions between dosage compensation complex components and the long non-coding RNA hsrω in Drosophila, showing hsrω suppresses lethality and restores chromatin structure when Msl-1 or Msl-2 are down-regulated.

Genomics and transcriptomics to unravel sex determination pathway and its evolution in sand flies

The paper identifies sex determination genes in sand flies using genomics and transcriptomics, proposes a model for their sex determination cascade, and characterizes a novel transformer homolog.

Timing mechanism of sexually dimorphic nervous system differentiation

The paper identifies a regulatory pathway controlling the timing of sexual differentiation in C. elegans and shows its conservation in mice and humans.

Multi-modal regulation of C. elegans hermaphrodite spermatogenesis by the GLD-1-FOG-2 complex

This study investigates the role of the GLD-1-FOG-2 complex in regulating C. elegans hermaphrodite spermatogenesis through multiple RNA-binding interactions and quantitative modeling.

Sex chromosome evolution via two genes

The paper shows sex chromosomes can evolve from autosomes through two genes: one suppressing female function and one promoting male function.

DEAH-box helicase 37 (DHX37) defects are a novel molecular etiology of 46,XY gonadal dysgenesis spectrum

This study identifies DHX37 variants as a novel molecular cause of 46,XY gonadal dysgenesis, particularly in embryonic testicular regression syndrome.

Extensive cellular heterogeneity of X inactivation revealed by single-cell allele-specific expression in human fibroblasts.

The paper uses single-cell allele-specific expression to identify novel XCI escapees and reveals cellular heterogeneity in XCI driven by XIST.

Recurrent gene amplification on Drosophila Y chromosomes suggests cryptic sex chromosome drive is common on young sex chromosomes

The paper shows that gene amplification on Drosophila Y chromosomes indicates recurrent meiotic drive, shaping sex chromosome evolution and genomic patterns.

The African Bullfrog (Pyxicephalus adspersus) genome unites the two ancestral ingredients for making vertebrate sex chromosomes

The paper presents a chromosome-level genome assembly of the African Bullfrog, revealing ancestral synteny among vertebrate sex chromosomes and showing the repeated use of two genomic blocks in sex chromosome evolution.

wnt4a Promotes Female Development and Reproductive Duct Elongation in Zebrafish

This paper shows that wnt4a promotes female sex determination and reproductive duct development in zebrafish, similar to its role in mammals.

fruitless functions downstream of doublesex to promote sexual dimorphism of the gonad stem cell niche

This study shows that fruitless (fru) is regulated by doublesex (dsx) in the gonad stem cell niche, promoting sexual dimorphism independently of Transformer-mediated alternative splicing.

Non-canonical Drosophila X chromosome dosage compensation and repressive topologically-associated domains

The paper investigates non-canonical dosage compensation on the Drosophila X chromosome, showing that repressive chromatin domains contribute to gene expression balance in males.

The sequence of a male-specific genome region containing the sex determination switch in Aedes aegypti

The paper sequences a male-specific genome region containing the sex determination switch gene Nix in Aedes aegypti.

CLAMP directly interacts with MSL2 to facilitate Drosophila dosage compensation

This study shows that CLAMP directly interacts with MSL2 to aid in the recruitment of the MSL complex to the X chromosome in Drosophila.

Single-cell transcriptomics of the mouse gonadal soma reveals the establishment of sexual dimorphism in distinct cell lineages

The paper uses single-cell RNA sequencing to study sex determination in mouse gonadal somatic cells, identifying early progenitors and sex-specific fate acquisition in different cell lineages.

Mosaic Turner syndrome shows reduced phenotypic penetrance in an adult population study compared to clinically ascertained cases

This study examines X chromosome aneuploidy in an adult population, finding reduced phenotypic penetrance in mosaic 45,X/46,XX cases compared to clinically ascertained cases.

Carriage of Supernumerary Sex Chromosomes Decreases the Volume and Alters the Shape of Limbic Structures.

This study examines how supernumerary sex chromosomes affect limbic structure volume and shape in patients compared to controls, finding reduced amygdala volume but no hippocampal volume changes after brain size correction.

De novo assembly of a young Drosophila Y chromosome using Single-Molecule sequencing and Chromatin Conformation capture

The paper assembles the Drosophila miranda Y chromosome using long reads and chromatin conformation capture, revealing its expansion through repetitive sequences.

The creation of sexual dimorphism in Drosophila gonad stem cell niches

The paper shows that in Drosophila, gonad stem cell niches can switch between male and female programs in dsx mutants, indicating dsx tips the balance rather than instructs the fate.

A zinc knuckle gene on the Y chromosome (zkY) determines sex in Atlantic cod (Gadus morhua)

The paper identifies a Y-linked gene zkY in Atlantic cod that functions as a master sex-determining gene by suppressing germ cell division in males.

Sex Chromosome Dosage Effects On Gene Expression In Humans

The paper investigates how sex chromosome dosage affects gene expression in humans by analyzing diverse aneuploidies and identifies SCD-sensitive genes and their regulatory networks.

Chromatin at X-linked repeats that guide dosage compensation in Drosophila melanogaster is modulated by the siRNA pathway

The paper investigates how the siRNA pathway modulates chromatin at X-linked repeats in Drosophila to guide dosage compensation by influencing X chromosome recognition.

Male mice with large inversions or deletions of X-palindrome arms are fertile and express their associated genes post-meiosis.

The paper investigates whether palindromic structures on the X chromosome are necessary for post-meiotic gene expression and fertility in male mice, finding that gene expression and fertility are unaffected by deletions of these regions.

Sex Determination in the garden lizard, Calotes versicolor: Is Environment a Factor?

The study investigates sex determination in C. versicolor, finding temperature does not regulate gonadal differentiation, AI induces male sex reversal, and a consistent sex bias occurs regardless of incubation conditions.

Conserved microRNA targeting reveals preexisting gene dosage sensitivities that shaped amniote sex chromosome evolution

The paper uses miRNA target site analysis to show preexisting gene dosage sensitivities influenced the evolution of mammalian and avian sex chromosomes.

Identification of general patterns of sex-biased expression in Daphnia, a genus with environmental sex determination

The paper identifies a core set of 675 genes with consistent sex-biased expression in three Daphnia species, showing a female overexpression bias and similar proportions to species with genetic sex determination.