Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

The X chromosome of the German cockroach, Blattella germanica, is homologous to a fly X chromosome despite 400 million years divergence

The paper investigates the homology between the X chromosomes of the German cockroach and flies, finding conserved genes and dosage compensation despite 400 million years of divergence.

Targeting of the dosage-compensated male X-chromosome during early Drosophila development

This study identifies how the MSLc complex targets the X-chromosome in Drosophila embryos using meiotic drive and ChIP-seq, revealing a multi-stage process involving CLAMP binding sites.

Heritability of skewed X-inactivation in female twins is tissue-specific and dependent on age

This study quantifies XCI skewing in female twins across tissues, showing age- and tissue-specific heritability and associations with smoking in older females.

RUNX1 safeguards the identity of the fetal ovary through an interplay with FOXL2

The paper identifies RUNX1 as a conserved regulator of fetal ovarian supporting cell identity, showing its interaction with FOXL2 in maintaining granulosa cell fate across species.

Multiple evidences suggest sox2 as the main driver of a young and complex sex determining ZW/ZZ system in turbot (Scophthalmus maximus)

The paper identifies sox2 as the main driver of the ZW/ZZ sex-determining system in turbot through genetic and genomic analyses.

Differential sperm motility mediates the sex ratio drive shaping mouse sex chromosome evolution

The paper shows that X-bearing sperm have greater motility than Y-bearing sperm in mice with Yq deletions, leading to a skewed sex ratio.

Transcriptional kinetics of X-chromosome upregulation

The paper analyzes allele-specific scRNA-seq data to show that X-chromosome upregulation in mouse cells occurs through increased transcriptional burst frequency.

Mapping of multiple complementary sex determination loci in a parasitoid wasp

The paper identifies four CSD candidate regions in Lysiphlebus fabarum, showing they lack homology with the honeybee's CSD gene and suggest a novel molecular mechanism for CSD in Hymenoptera.

Identification of a female determinant gene for the sexual determination of a hemipteran insect, the brown planthopper

The paper identifies NlFmd as a female determinant gene in the brown planthopper, showing its role in sex determination and its conservation in related species.

Hemimetabolous insects elucidate the origin of sexual development via alternative splicing

This paper investigates the evolution of sexual development in insects by analyzing dsx and tra expression in three hemimetabolous insect orders, revealing a gradual, mosaic evolution of the tra-dsx splicing cascade.

The Non-random Location of Autosomal Genes that Participate in X Inactivation

The paper identifies autosomal genes on chromosomes 1 and 19 involved in X inactivation, showing their non-random genomic organization and evolutionary conservation.

tudor-domain containing protein 5-prime promotes male sexual identity in the Drosophila germline and is repressed in females by Sex lethal

The paper identifies tdrd5p as a gene repressed by Sxl in female Drosophila germ cells and essential for male germline identity and fertility.

Müllerian-inhibiting substance (MIS) is both necessary and sufficient for testicular differentiation in Chinese soft-shelled turtle Pelodiscus sinensis

This study shows that Mis is essential and sufficient for testicular differentiation in the Chinese soft-shelled turtle, demonstrating its role in reptilian sex determination.

Response to \"Expression reduction of biallelically transcribed X-linked genes during the female human preimplantation development.\"

The paper challenges a previous study's conclusion about X-linked gene expression reduction in human preimplantation embryos, arguing that the original analysis was based on flawed premises.

Minimal effects of proto-Y chromosomes on house fly gene expression in spite of evidence that selection maintains stable polygenic sex determination

The paper examines the effect of proto-Y chromosomes on gene expression in house flies and finds minimal effects despite evidence of selection maintaining polygenic sex determination.

Systematic Allelic Analysis Defines the Interplay of Key Pathways in X Chromosome Inactivation

The paper systematically analyzes Xist-mediated allelic silencing in ES cells, identifying key factors and their roles in gene silencing during X chromosome inactivation.

Modular tissue-specific regulation of doublesex underpins sexually dimorphic development in Drosophila

The paper identifies modular cis-regulatory elements that control doublesex expression in sexually dimorphic structures in Drosophila legs and genitalia.

Mechanistic diversification of XIST regulatory network in mammals

The paper investigates the mechanistic differences in XIST regulatory networks between humans and mice, showing that JPX regulates XIST expression through distinct mechanisms in each species.

The Drosophila fertility factor kl-3 is linked to the Y-chromosome of the vector of Chagas’ disease Triatoma infestans (Hemiptera: Reduviidae) and is essential for male fertility

This paper identifies a Y-linked gene in Triatoma infestans orthologous to Drosophila kl-3, showing it is essential for male fertility through knockdown experiments.

Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features

The paper predicts Xist-induced gene silencing kinetics using a Random Forest model based on epigenetic and genomic features, identifying key factors like distance to Xist and promoter pre-marking.

Expression reduction of biallelically transcribed X-linked genes during the human female preimplantation development

The paper reanalyzes previous findings on X-linked gene expression in human preimplantation embryos and challenges a recent reanalysis that disputes biallelic expression dampening.

Specific miRNA-GPCR networks regulate Sox9a/Sox9b activities to promote gonadal renewal in zebrafish

The paper identifies miRNA-GPCR regulatory networks that control Sox9a/Sox9b activities, influencing gonadal renewal in zebrafish.

CBX2 is required during male sex determination to repress female fate at bivalent loci

This study shows that CBX2 represses female fate by maintaining bivalent female-determining genes in male gonads, enabling Sry expression and testis development.

Early sex-chromosome evolution in the diploid dioecious plant Mercurialis annua

This study identifies the sex chromosome in Mercurialis annua using genomic and transcriptomic data, revealing suppressed recombination and X/Y sequence divergence without extensive Y-chromosome degeneration.

Single-cell RNA-seq reveals distinct dynamic behavior of sex chromosomes during early human embryogenesis

The paper analyzes single-cell RNA-seq data from human embryos to compare gene expression between males and females, identifying differences in sex chromosome activation and dosage compensation during early development.

Instability of the pseudoautosomal boundary in house mice

The paper examines PAR boundary instability in house mice subspecies, showing high recombination rates and copy-number variation.

GA-repeats on mammalian X chromosomes support Ohno’s hypothesis of dosage compensation by transcriptional upregulation

The paper shows GA-repeats on mammalian X chromosomes support Ohno's hypothesis of dosage compensation by transcriptional upregulation through convergent evolution.

Sex differences in gene expression in the human fetal brain

The paper analyzes RNA sequencing data from human fetal brains to identify sex-biased gene expression, finding differences in 2558 autosomal and 155 X-chromosome genes, with implications for neurodevelopmental disorders.

Nr5a1 suppression during the fetal period optimizes ovarian development by fine-tuning of Notch signaling

This paper shows that Nr5a1 suppression during fetal development optimizes ovarian development by fine-tuning Notch signaling, using mouse models with altered Nr5a1 expression.

Human Genes Escaping X-inactivation Revealed by Single Cell Expression Data

The paper identifies X-chromosome escapees using single-cell RNA-Seq in fibroblasts and lymphoblasts, finding 24 and 49 candidates, respectively, with 66% previously reported and 11 being lncRNAs.