interferon and immune responses

This study identifies TRIM52 as a negative regulator of IFN-β production by promoting TBK1 ubiquitination and proteasomal degradation.

This study shows that C. elegans STA-1, a STAT-like protein, relocalizes from nuclei to cytoplasm during viral infection, acting cell-intrinsically to repress anti-viral defense.

This study uses in vivo single-cell analysis to show that type I IFN signaling and NK cells limit MHV68 infection in lymph nodes, with IFNAR deficiency increasing infected B cell numbers and NK cell depletion enhancing viral spread.

The paper shows that type I interferon primes alveolar epithelial cells for regeneration by enhancing their response to reparative signals from tissue-resident macrophages after viral infection.

The paper shows human ISGs can restrict bacterial phage replication, revealing conserved antiviral mechanisms across kingdoms.

This study characterizes the antiviral activities and regulatory mechanisms of diverse IFITM proteins in macaques, showing how gene duplication and retrotransposition generate functional diversity in antiviral defenses.

This paper identifies lineage-specific chromatin accessibility differences at IFN gene loci in pDCs and epithelial cells, revealing ETS-IRF composite elements as key regulators of divergent interferon responses.

This paper shows that reducing Profilin-1 in breast cancer cells triggers genomic instability and activates the cGAS-STING pathway, enhancing T cell-mediated anti-tumor immunity and leading to tumor regression.

The paper shows non-cyclic dinucleotide STING agonists effectively suppress MPXV infection by bypassing poxin-mediated inhibition, leading to reduced viral replication and improved survival in mice.

The paper disrupts the synergistic immune evasion of dengue virus by targeting IFIT1-STAT2, resulting in an attenuated virus that enhances innate immune priming.

This study identifies RNF213 as an IFN-gamma-induced antiviral protein that inhibits coronavirus translation by targeting nascent double membrane vesicles.

The paper establishes an immune-competent airway organoid model to study how macrophages, neutrophils, and monocytes respond to influenza virus in the human upper airway.

The paper identifies ZNF346 as a regulator of PKR activation by analyzing the composition of dRIFs and their functional roles in dsRNA response regulation.

This study identifies IFN homologs in jawless vertebrates and demonstrates their antiviral function, tracing the evolutionary origin of IFN to basal chordates.

This study compares HSV-1 and PRV sensitivity to IFN-λ, showing HSV-1's neuron-specific resistance and identifying RSAD2 as a key antiviral factor in neurons.

The paper shows replication stress causes rDNA instability, leading to immunostimulatory RNA that activates RLR signaling and drives inflammation.

This study identifies cGAS-STING pathway activation as a key mechanism of inflammation in VEXAS, showing that UBA1 mutations disrupt ERAD and mitochondrial homeostasis, leading to STING-driven inflammation.

The paper shows that rDNA breaks generate sense-antisense rRNA transcripts that activate immune signaling via MDA5 and RIG-I.

This study shows XAF1 protects against viral-induced neuropathogenesis by limiting excessive IFN responses in neurotropic virus infections.

This study shows that IRF7 deficiency worsens influenza A disease in mice, independent of TLR7, by impairing early interferon responses and adaptive immunity.

The paper shows that cGAS hyperactivates in response to unpaired DNA (Bu-DNA) by bending it into a V-shape, revealing a new activation mechanism.

The paper develops a computational model of influenza A virus infection that simulates semi-infectious particles and genome complementation, showing how these factors influence IFN response and viral load in respiratory epithelial cells.

This study identifies RNA length as a species-specific threshold for innate immune recognition, showing that different RNA sensors (RIG-I and MDA5) determine antiviral sensing across human, duck, and chicken cells.

This study shows cGAS forms a protein-dsDNA mesh that enables dsDNA-specific and length-dependent activation through higher-order assembly.

The paper shows neutrophils store and release IFN-I from the nucleolus, revealing a new role for nucleolar stress in immune responses.

This paper develops a Zbp1-floxed mouse model to study ZBP1's role in PANoptosis and its therapeutic potential across different cell types.

The paper shows that dsRNA mycoviruses in Aspergillus fumigatus enhance MDA5/MAVS signaling and reduce virulence in chronic allergic aspergillosis.

The paper characterizes gene regulatory networks in human airway epithelial cells and identifies cell type-specific responses to type I interferon.

This study shows that loss of DHCR7 leads to increased 7DHC, which activates IRF3 and impairs anti-bacterial immunity against Mycobacterium marinum in zebrafish.

This study identifies LSM14A's role in antiviral immunity independent of its localization to P-bodies and peroxisomes, revealing a specialized interaction network that enhances innate immune signaling.