A. Das

B cell receptor repertoire analysis unveils dynamic antibody response and severity markers in COVID-19 patients

The paper analyzes B cell receptor repertoires in COVID-19 patients to identify antibody response dynamics and severity markers.

Activation of the neonatal immune system in healthy neonates within hours of birth.

This study identifies rapid immune cell changes in neonates within hours of birth, showing increased effector T cell proliferation and cytokine production.

Conserved basal lamina proteins, laminin and nidogen, are repurposed to organize mechanosensory complexes responsible for touch sensation.

This study shows that laminin and nidogen in the basal lamina form complexes with the MEC-4 channel to enable touch sensation in C. elegans.

The CRISPR-Cas System differentially regulates surface-attached and pellicle-biofilm in Salmonella enterica serovar Typhimurium

This study shows the CRISPR-Cas system in Salmonella Typhimurium promotes surface-biofilm while inhibiting pellicle-biofilm through gene regulation of flagellar, curli, and cellulose pathways.

BESFA: Bioinformatics based Evolutionary, Structural & Functional Analysis of Prostrate, Placenta, Ovary, Testis, and Embryo (POTE) Paralogs

This study analyzes the POTE protein family to understand their structure, function, and adaptive divergence, identifying potential therapeutic applications in cancer.

Synergistic collagen-condiment: Streptococcal collagen-like (Scl) protein in cell-adhesion and diabetic wound-closure matrix

This study investigates the biomaterial potential of recombinant Streptococcal collagen-like (rScl1) protein, showing its non-cytotoxicity, cell-adhesion support, and efficacy in diabetic wound closure with increased type III collagen.

Active Segregation Dynamics in the Living Cell

The paper develops an active version of Flory-Huggins theory to model nonequilibrium phase segregation in living cells driven by active stresses, highlighting unique dynamics like anomalous growth and mesoscale segregation.

Cells use molecular working memory to navigate in changing chemoattractant fields

The paper shows cells use a molecular working memory mechanism to maintain directional migration in changing chemoattractant fields by memorizing disrupted signals while adapting to new cues.

A phylogenetically-restricted essential cell cycle progression factor in the human pathogen Candida albicans

The paper identifies CSA6 as a clade-specific cell cycle progression factor in Candida albicans, essential for mitotic exit and a potential antifungal target.

Production and characterization of virus-free, CRISPR-CAR T cells capable of inducing solid tumor regression

This study produces and tests virus-free CRISPR-CAR T cells that effectively regress solid tumors in vivo.

CD4+ T cell lymphopenia and dysfunction in severe COVID-19 disease is autocrine TNF-α/TNFRI-dependent

The paper shows that autocrine TNF-α/TNFRI signaling drives CD4+ T cell lymphopenia and dysfunction in severe COVID-19, and TNF-α blockade improves outcomes.

The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate

This study examines the impact of maternal SARS-CoV-2 infection on neonatal immunology, finding increased pro-inflammatory cytokines and immune cell percentages in infants exposed in utero.

Arp2/3 mediated dynamic lamellipodia of the hPSC colony edges promote liposome-based DNA delivery

This study identifies Arp2/3-dependent lamellipodia at hPSC colony edges as a mechanism for enhanced cationic liposome transfection, while epithelial-like core cells use receptor-mediated endocytosis.

Why does Δ9-Tetrahydrocannabinol act as a partial agonist of cannabinoid receptors?

This study investigates the molecular mechanism of partial agonism in cannabinoid receptors, finding that THC stabilizes both agonist and antagonist-like poses through its alkyl side chain, leading to partial receptor activation.

Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells

The paper develops a FRET biosensor using intrinsically disordered proteins to monitor osmotic stress effects across multiple organisms.

Nef dimerization defect abrogates HIV viremia and associated immune dysregulation in the Bone Marrow-Liver-Thymus-Spleen (BLTS) humanized mouse model

The paper shows that preventing Nef dimerization in HIV reduces viremia and immune dysregulation in a humanized mouse model.

-actinin-4 drives invasiveness by regulating myosin IIB expression and myosin IIA localization

This study shows ACTN4 regulates cancer cell invasiveness by controlling NMM IIB expression and NMM IIA localization during 3D invasion.

Inhibition of Extracellular Vesicle-Associated MMP2 Abrogates Intercellular Transfer of Hepatic miR-122 to Tissue Macrophages and Curtails Liver Inflammation

The paper shows that inhibiting MMP2 on extracellular vesicles reduces miR-122 transfer to macrophages, thereby decreasing liver inflammation.

The molecular and metabolic program for adaptation of white adipocytesto cool physiologic temperatures

This study investigates how white adipocytes adapt to cooler temperatures, finding changes in gene expression, lipid metabolism, and energy source utilization.

Nicotinamide mononucleotide (NMN) de-amidation by host-microbiome interactions

This study shows orally delivered NMN undergoes deamidation and incorporation into mammalian tissue via the de novo pathway, with microbiome disruption reducing this process and increasing gut NAD+ availability.

Receptor-independent membrane mediated pathways of serotonin action

This study shows serotonin can directly modulate membrane properties and cellular processes without acting through receptors.

Monocyte Subsets with High Osteoclastogenic Potential and Their Epigenetic Regulation Orchestrated by IRF8

The paper identifies monocyte subsets with high osteoclastogenic potential and shows IRF8 regulates their epigenetic and transcriptional programs.

Skin protective effects of RM191A, a novel superoxide dismutase mimetic

This study evaluates RM191A, a novel SOD mimetic, showing enhanced antioxidant activity and protective effects against UV-induced DNA damage and inflammation in skin models.

Tumor neoantigen heterogeneity impacts bystander immune inhibition of pancreatic cancer growth

This study investigates how neoantigen heterogeneity affects bystander immune inhibition in pancreatic cancer, finding that high neoantigen frequency is needed for effective antitumor response, which can be improved with immune therapy.

Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel

This paper identifies novel endocannabinoid epoxides that modulate TRPV1 and cannabinoid receptors, reducing inflammation and offering potential for new therapeutics.

Rational design of protein-specific folding modifiers

This paper designs a method to create protein-specific folding modifiers using xenonuclei, showing they can accelerate protein refolding by 33% under specific conditions.

Controlled neighbor exchanges drive glassy behavior, intermittency and cell streaming in epithelial tissues

This study shows that rate-limited T1 transitions in epithelial tissues lead to glassy behavior, intermittency, and cell streaming, with predictions validated against Drosophila pupal development experiments.

Development of humanized mouse and rat models with full-thickness human skin and autologous immune cells

This paper develops humanized mouse and rat models with full-thickness human skin and autologous immune cells to study human host-skin pathogen interactions.

Defined microbiota transplant restores Th17/RORtγ+ regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotas

The paper shows that transplanting healthy microbiota into mice with IBD microbiotas restores Th17/RORγt+ regulatory T cell balance by reducing pathogenic strains.

Physico-biochemical and molecular responses of Acacia auriculiformis to salinity stress

This study investigates the physiological, molecular, and antioxidant responses of Acacia auriculiformis to varying salinity levels, identifying key enzymes, metabolites, and gene expression patterns associated with salt tolerance.