MicroRNA in disease regulation

Structural features within precursor microRNA-20a regulate Dicer-TRBP processing

This study determines the structure of pre-miR-20a and identifies structural features that regulate its Dicer-TRBP processing and maturation efficiency.

miR-210 locus deletion disrupts cellular homeostasis; an integrated genetic study

This study examines the effects of miR-210 locus deletion on cellular homeostasis in human and mouse cells, revealing deregulation of neighboring genes and unexpected lack of miR-210 target enrichment.

Human rhinovirus 16 infection of Hela-Ohio and HEp-2 cells modifies micro RNA expression across the viral life-cycle

This study identifies miRNAs differentially expressed during RV16 infection and links them to host genes involved in antiviral responses and viral progression.

Molecular mechanisms of sexual dimorphism in cancer through improved miRNA regulation-level network-based approach: MIRROR2

This study develops MIRROR2, a network-based method to identify sex-specific regulatory mechanisms in cancer by analyzing miRNA and target gene expression across three cancer types.

miR-29a-3p and TGF-beta Axis in Fanconi Anemia: Mechanisms Driving Metabolic Dysfunction and Genome Stability

This study identifies miR-29a-3p as a regulator of metabolic dysfunction and genome stability in Fanconi anemia by modulating the PI3K/AKT and TGF-beta pathways.

Benchmarking microRNA Target Prediction Algorithms Using Single-Cell Co-Sequencing Data

This study benchmarks miRNA target prediction algorithms using single-cell co-sequencing data, showing varying performance across species and target numbers.

Host microRNA Target Prediction in SARS-CoV-2 and Hepatitis E Virus Genomes: Insights from RNAhybrid Analysis

This study predicts host miRNA binding sites in SARS-CoV-2 and Hepatitis E Virus genomes using RNAhybrid, identifying potential regulatory interactions with strong free energy values.

MicroRNA-502-3p modulates the GABA A subunits, synaptic proteins and mitochondrial morphology in hippocampal neurons

This study examines how miR-502-3p affects GABA A subunits, synaptic proteins, mitochondrial morphology, and gene expression in hippocampal neurons.

Metastatic niche mediated activation of metastasis initiating cells in ovarian cancer through miR-193b-3p downregulation via the ERK/EZH2/DNMT1 axis

This study identifies miR-193b-3p downregulation via the ERK/EZH2/DNMT1 axis in ovarian cancer metastasis initiating cells, showing its role in promoting cancer stem cell properties and invasion.

Evaluating Genetic Regulators of MicroRNAs Using Machine Learning Models

This study uses machine learning to predict miRNA expression and identify genetic regulators, revealing miRNA-gene regulatory relationships and pathway-specific associations.

miRNA-Mediated Regulation of Gene Expression During Early Activation in Jurkat Cells

The paper analyzes miRNA-mediated gene regulation during early T cell activation using multi-omics data, revealing distinct regulatory patterns based on translation efficiency and miRNA binding site density.

Early Candida - Oral Tumor Interactions Suggest miRNA-Mediated Regulation of Inflammatory and Tumor-associated processes

This study investigates how Candida species influence oral cancer progression through miRNA regulation, showing C. albicans drives oncogenic pathways while C. parapsilosis affects metabolic processes.

SOX10 and microRNAs: decoding their interplay in regulating melanoma plasticity

This paper reviews the interplay between SOX10 and microRNAs in melanoma, identifying key network motifs and their role in regulating tumor plasticity and therapy resistance.

MicroRNA-29a-5p attenuates hemorrhagic transformation and improves outcomes after mechanical reperfusion for acute ischemic stroke

This study shows that miR-29a-5p reduces astrocyte injury and HT in ischemia-reperfusion models, improving outcomes in acute ischemic stroke.

Peptide Barcodes for miRNA activity assessment in mammalian cells

This study introduces peptide barcodes to measure multiple miRNA activities in parallel, validated by fluorescent reporters, and demonstrates robust profiling across three cell lines.

A spatio-temporal brain miRNA expression atlas identifies sex-independent age-related microglial driven miR-155-5p increase

The paper creates a spatio-temporal miRNA atlas in mice, identifying age-related miR-155-5p increase driven by microglia, independent of sex.

Sequence based prediction of cell type specific microRNA binding and mRNA degradation for therapeutic discovery

This paper introduces REPRESS, a deep learning model that predicts cell-type-specific microRNA binding and mRNA degradation from RNA sequences, outperforming existing methods in multiple tasks.

Cell Type-Specific Effects of miR-21 Loss Attenuate Tumor Progression in MYC-Driven Prostate Cancer

This study shows that loss of miR-21 in MYC-driven prostate cancer reduces tumor progression by affecting cell-type-specific gene regulation and immune infiltration.

Novel features of miRNA and isomiR-mRNA interactions

The paper identifies 1,747 isomiRs and over 5 million microRNA/isomiR-mRNA interactions, finding that isomiRs bind mRNAs differently from their parent microRNAs.

Let-7 restrains an oncogenic circuit in AT2 cells to prevent fibrogenic cell intermediates in pulmonary fibrosis

This study identifies let-7 as a regulator of AT2 cell differentiation and fibrosis prevention by controlling oncogenic networks and epigenetic changes.

Nuclear Argonaute:miRNA complexes recognize target sequences within chromatin and silence gene expression

This study identifies nuclear miRNA:Argonaute complexes and their chromatin-associated RNA targets, showing miRNA-mediated gene silencing occurs in both nucleus and cytoplasm.

The up-regulation of TGF-beta1 by miRNA-132-3p/WT1 is involved in inducing leukemia cells to differentiate into macrophages

This study shows that miRNA-132-3p/WT1/TGF-beta1 axis regulates the differentiation of THP-1 leukemia cells into macrophages.

Evidence of target-mediated miRNA degradation in Drosophila ovarian cell culture

The paper investigates target-mediated miRNA degradation (TDMD) in Drosophila ovarian cells, showing that Dora, the Drosophila ortholog of ZSWIM8, mediates miRNA degradation and affects Notch signaling.

miR-631 suppresses oncogene RAB11A in oral squamous cell carcinoma

This study identifies miR-631 as a tumor suppressor in OSCC that targets RAB11A, reduces proliferation, and promotes apoptosis, with potential therapeutic applications.

mmu-miR-1291 Alleviates Oxidative Damage in Myocytes by Modulating the Process of Gene-Mediated Ubiquitination

The paper identifies a miRNA that regulates oxidative stress in myocytes by modulating Wsb1 expression and the NF-κB signaling pathway.

miRNA-29-CLIP uncovers new targets and functions to improve skin repair

This study identifies miRNA-29 targets and functions in skin repair using miRNA-CLIP and ASO, revealing roles in protein folding, RNA processing, and cell adhesion.

A microRNA-based Therapy against Human Medulloblastoma Validated in a Xenotransplant Model using Wild-Type Mouse Embryos

This study evaluates miRNA-based therapy for medulloblastoma using a xenotransplant model, showing reduced tumor growth and invasiveness through miRNA restoration.

miRBench: novel benchmark datasets for microRNA binding site prediction that mitigate against prevalent microRNA Frequency Class Bias

The paper introduces miRBench, a benchmark dataset for microRNA binding site prediction that reduces miRNA frequency class bias, showing improved performance with a simple CNN model.

Modulating populational variance of methyl-guanine methyl transferase expression through miR-181d degradation: a novel mechanism of temozolomide resistance

The paper shows that miR-181d degradation via a PNPT1-ATR feed-forward loop increases MGMT expression variance, leading to temozolomide resistance in glioblastoma cells.

Chasing non-existent microRNAs in cancer

The paper investigates whether reported miRNAs in cancer are functionally active, finding many are not incorporated into RISC and lack endogenous silencing capability.