Parkinson's Disease Mechanisms and Treatments

This study explores associations between coffee, smoking, and aspirin use with age at onset and clinical severity in idiopathic Parkinson's disease using a large cohort.

The paper investigates mitonuclear SNP combinations in Parkinson's disease cohorts and identifies five significant interactions associated with disease risk.

The paper identifies a kinase inhibitor, BX795, that rescues pathological phenotypes in a patient-derived Parkinson's disease model through proteomic analysis and high-content screening.

This study shows that grafts of neural precursors reverse cognitive and motor symptoms in a non-human primate model of Parkinson's disease.

This study introduces a modified Real-Time Quaking-induced Conversion assay to assess alpha-synuclein seeding activity in multiple system atrophy, revealing heterogeneity in seeding behavior across brain regions.

This study uses CRISPR/Cas9 to delete A53T-SNCA in a rat model of Parkinson's disease, showing reduced -synuclein levels and improved motor symptoms.

This study identifies gene regulatory networks influenced by Parkinson's disease risk SNPs using eQTL and chromosomal conformation data across multiple tissues.

This study investigates metabolic changes in a Drosophila Parkinson's disease model with DJ-1 deficiency, identifying altered pathways and potential therapeutic targets.

The paper compares aggregated alpha-synuclein in Parkinson's disease and multiple system atrophy brains to determine their proteomic composition and potential cross-seeding mechanisms.

This study identifies TRIM1 as an E3 ligase that ubiquitinates LRRK2, regulating its localization, degradation, and toxicity in Parkinson's Disease.

This paper presents a multiscale computational model of the cortico-basal ganglia system to simulate arm reaching behavior under normal, Parkinsonian, and levodopa conditions, showing how SNc cell loss and medication affect motor performance.

The paper uses machine learning to identify six genetic variants and tissue-specific eQTL effects linked to Parkinson's disease risk.

The paper uses single-cell RNA sequencing to analyze gene expression changes in the substantia nigra pars compacta of pesticide-exposed mice, identifying differentially expressed genes and highlighting the role of support cells in pesticide-induced Parkinson's disease.

This study identifies reduced thalamic excitation to motor cortical pyramidal tract neurons in a mouse model of parkinsonism, mediated by NMDA receptor overactivation and reversible via chemogenetic suppression of basal ganglia outputs.

This study examines oculomotor function in Parkinson's disease patients, finding task- and stimulus-specific preservation of eye movements in response to dynamic targets.

This study compares [11C]UCB-J and [18F]FDG PET in a 6-OHDA rat model of Parkinson's disease, finding divergent changes in synaptic density and metabolic function in CSTC circuits.

This study shows that Gastrodia elata Blume extract protects against LRRK2-G2019S Parkinson's disease by activating glial Nrf2 and inhibiting Mad/Smad signaling in both fly and mouse models.

The paper investigates developmental differences in mouse nigra that correlate with vulnerability to Parkinson disease, finding that CD-1 and crossbred mice show greater resilience due to reduced cell death and earlier neuronal maturation.

This study shows that inhibiting LRRK2 kinase activity increases α-synuclein presynaptic localization and anterograde axonal transport in neurons.

The paper reports a small molecule that suppresses levodopa-induced dyskinesia in a nonhuman primate model of Parkinson's disease.

This study investigates whether cortical injection of alpha-synuclein preformed fibrils (PFF) affects interval timing in mice, finding no consistent deficits despite synucleinopathy.

The paper investigates whether variants in the PTRHD1 gene are associated with Parkinson's disease risk and age at onset in European populations, finding no significant associations.

The paper investigates USP30 inhibition's role in enhancing Parkin-mediated mitophagy using pharmacological and genetic approaches in cellular models.

This study shows that PLK2 inhibition reduces soluble nuclear pS129 levels but not aggregated pS129 in synucleinopathy models.

This study fine-maps Parkinson's disease susceptibility loci to identify putative causal variants and their mechanisms of action.

The paper identifies gene expression patterns linked to cortical thickness changes in Parkinson's disease using MRI and transcriptomic data, revealing pathways related to cellular maintenance mechanisms.