DNA Repair Mechanisms

This study shows that RPA1 is critical for DNA damage repair in oocytes, leading to infertility when disrupted.

This paper identifies two distinct MUS81 inhibitors that enhance chemotherapy efficacy by impairing DNA repair in cancer cells.

This study shows that BLM helicase is essential for resolving ultrafine DNA bridges during mitosis, preventing genomic instability.

This study shows that deficiencies in Fanconi Anemia or homologous recombination pathways enhance the antitumor effects of CP-506, a hypoxia-activated prodrug, through synthetic lethality mechanisms.

The paper shows that AT/TA repeats form DNA structures that are processed by nucleases and repositioned to the nuclear periphery for repair.

This study presents a cryo-EM structure of the human CTF18-RFC complex bound to PCNA, revealing structural features important for PCNA loading and Pol ε-mediated leading strand synthesis.

This study tracks DNA damage and chromatin remodeling in live cells using Hoechst-based imaging, showing PARP1 dynamics and chromatin relaxation kinetics.

The paper investigates how MRE11 suppresses germline mutagenesis at meiotic double-strand breaks in mice by analyzing the effects of DSB processing and end joining.

The paper shows PTBP2 stabilizes Pol{kappa} mRNA, leading to genomic instability in CML cells by interacting with MRE11 and promoting DNA damage.

This study identifies SFPQ as a factor promoting homologous recombination by stabilizing RAD51 and its paralogs' mRNA, independent of DSB localization or p53 activation.

The paper studies mutations and structural variants during double-strand break repair in budding yeast, finding that repair-associated deletions and template switches depend on microhomology and homeology.

This study identifies a type I interferon signaling signature in XPC-deficient keratinocytes, linking UVB exposure to JAK/STAT pathway dysregulation and hypersensitivity.

The paper measures repair kinetics during C. elegans meiosis and finds similar rates for sister- and homolog-directed repair, challenging the assumption of homolog bias.

This study shows DNA polymerase η is regulated by both mono-ubiquitination and mono-NEDDylation at the same lysine residues, with NEDDylation disrupting foci formation.

The paper uses proteomic profiling to identify DNAJC9 and MCM2 as key histone chaperones involved in chromatin repair during UV damage response in human cells.

The paper identifies PAF15-PCNA assembly as a rate-limiting factor for lagging strand replication and replisome integrity, showing its regulation by the S-phase checkpoint.

This study reveals a non-catalytic role for RFC in stabilizing PCNA-Polδ interactions during DNA synthesis, essential for processive replication.

This study shows that obese serum increases DNA damage, reduces DNA repair, activates DDR pathways, and promotes colon cancer cell proliferation.

This study identifies JAK1 as a driver of tumor cell radiosensitivity and shows that Kif18a inhibition can counteract therapeutic resistance by exacerbating mitotic stress.

This study reveals how SCFFBH1 promotes fork reversal and regulates RAD51 through DNA binding and ubiquitination, using cryo-EM structures and in vitro experiments.

This study investigates the role of XPG interactions with TFIIH subunits p62 and XPD in nucleotide excision repair, showing their importance for catalytic activity and incision initiation.

This study shows that super-enhancer activity influences transcription stress and DNA break repair dynamics in cancer, with γH2AX marking linked to DSB turnover and mutagenic vulnerability.

The paper demonstrates that OGG1 uses coordinated amino acids to efficiently detect 8-oxoG lesions in DNA.

The paper investigates how recombination context affects nucleolar architecture in yeast by analyzing Cdc14 localization during meiotic prophase I.

This study identifies REV7 as a novel binding partner of ATRIP that inhibits ATR kinase activity and negatively regulates ATR signaling.

This study shows that phosphorylation of RAD51AP1 at S277/282 regulates its function in homology-directed DNA repair, with phosphomimetic variants enhancing its activity.

This study identifies Rad51 mutations that shift post-replication repair pathway usage from homologous recombination to alternate pathways by affecting fork protection.

This study shows Rad18 suppresses 4NQO-induced oral carcinogenesis but not KrasG12D-driven lung tumors, highlighting context-specific tumor-suppressive roles.

MUSICiAn identifies DNA repair genes by analyzing mutational spectra from CRISPR-Cas9 perturbations without controls, revealing known genes and novel candidates.