Hearing, Cochlea, Tinnitus, Genetics

Behavioral tinnitus in gerbils is associated with reduced spontaneous rates in single auditory-nerve fibers

This study shows that tinnitus in gerbils is linked to reduced spontaneous activity in specific auditory nerve fibers, supporting models of central hyperactivity in tinnitus.

Integrating GWAS meta-analysis with human brain cell mapping implicates the amygdala and the midbrain in the pathogenesis of tinnitus

The paper integrates GWAS meta-analysis with human brain cell mapping to identify genetic loci and cell types involved in tinnitus, implicating the amygdala and midbrain.

A computational model of the mammalian auditory periphery with a multichannel, energy-driven, medial olivocochlear reflex

This paper introduces a computational model of the mammalian auditory periphery that includes a medial olivocochlear reflex pathway, showing its ability to simulate effects of contralateral elicitors on auditory-nerve responses.

Increased basal ganglia volume in older adults with tinnitus

The paper examines subcortical structures and auditory function in older adults with tinnitus, finding increased basal ganglia volume but no differences in auditory areas.

Trophic and temporal dynamics of macrophage biology in human inner ear organogenesis

The paper identifies seven macrophage subtypes in the human inner ear across development and adulthood using scRNA-seq data, linking them to specific developmental stages and gene expression profiles.

Increased vulnerability to noise exposure of low spontaneous rate type 1C spiral ganglion neuron synapses with inner hair cells (Pre-Print)

The study investigates noise-induced vulnerability of low spontaneous rate type 1C spiral ganglion neuron synapses in C57Bl/6J mice using an LYPD1 reporter model and finds increased vulnerability of LYPD1-positive synapses.

Activity and retinoic acid drive hair cell spatial patterning in the zebrafish utricle

The paper shows that retinoic acid and hair cell activity jointly determine spatial patterning in zebrafish utricle hair cells.

Spontaneous otocoherence of the active ear

The paper introduces a method to analyze SOAE phase to quantify otocoherence across species, revealing correlations with auditory nerve fiber tuning and providing insights into active cochlear mechanics.

A tissue boundary orchestrates the segregation of inner ear sensory organs

The paper identifies a tissue boundary that facilitates the segregation of inner ear sensory organs in mice and chickens, showing its role in cell fate and actomyosin dynamics.

Modelling Auditory Enhancement: Efferent Control of Cochlear Gain can Explain Level Dependence and Effects of Hearing Loss

This paper models auditory enhancement using a subcortical auditory model with MOC efferent gain control, replicating psychoacoustic findings on level dependence and hearing loss effects.

A Pilot Study on Assessing Auditory Masking Using Auditory Steady-State Responses

This study assesses auditory masking using Auditory Steady-State Responses (ASSR) without requiring active participant engagement, finding that ASSR amplitude decreases with masker presence and varies with center frequency and sound levels.

Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy

This study uses MINFLUX nanoscopy to map the nanoscale organization of proteins at inner hair cell synapses in mice, revealing nanocluster-based structures in active zones and postsynaptic densities.

Loss of function and structural variants in the PRKRA synaptic gene link mild cognitive impairment and tinnitus

The paper identifies rare PRKRA variants in individuals with tinnitus and mild cognitive impairment, linking them to early cognitive decline and suggesting a potential role in disease mechanisms.

Coexistence of asymmetric cell shape dynamics governs organisational diversity in sensory epithelia

The paper identifies cell-shape dynamics as a mechanism for generating organisational diversity in sensory epithelia across species.

Large-scale audiometric phenotyping identifies distinct genes and pathways involved in hearing loss subtypes

This study identifies distinct genes and pathways for sensory and metabolic hearing loss using large-scale audiometric phenotyping and sex-stratified analyses.

Structural Mechanism of Prestin-Membrane Mechanotransduction

This study reveals how prestin translates membrane tension into charge and motor movement during sound-evoked vibrations through structural analysis and complementary experiments.

Timing of delamination of inner ear neurons specifies their topography and target innervation

The paper shows that the timing of inner ear neuron delamination determines their topography and target innervation in the developing eighth cranial nerve.

The tree cricket ear is a highly phase sensitive biomechanical interferometer.

The paper demonstrates that tree crickets use a biomechanical interferometer in their auditory system to precisely localize sound by detecting microsecond time delays through mechanical interference.

Intracochlear pressure measurements quantify overall noise exposure to the inner ear during mastoidectomy

The paper measures intracochlear pressure during mastoidectomy to quantify noise exposure to the inner ear and finds levels exceeding 120 dBA, with a peak at 1.33 kHz.

Probing the role of synaptic adhesion molecule RTN4RL2 in setting up cochlear connectivity

This study investigates the role of RTN4RL2 in cochlear synapse formation and function, finding that its deletion leads to synaptic abnormalities and hearing impairment in mice.

Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing

The paper investigates the structure and function of otoferlin, showing how it binds Ca2+ and facilitates synaptic vesicle fusion in inner hair cells.

Co-release of GABA and ACh from medial olivocochlear neurons fine tunes cochlear efferent inhibition

The paper shows that GABA and ACh are co-released from MOC terminals, modulating cholinergic inhibition at IHC synapses during development.

Retinoic acid signaling guides the efficiency of inner ear organoid-genesis and governs sensory-nonsensory fate specification

The paper identifies retinoic acid signaling's role in inner ear organoid development, showing it affects organoid efficiency and sensory-nonsensory fate specification.

A single-cell transcriptomic atlas of inner ear morphogenesis in zebrafish

The paper uses single-cell RNA sequencing to analyze inner ear development in zebrafish, identifying cell states and genes involved in sensory patches, semicircular canals, and endolymphatic sac formation.

Spontaneous calcium transients in hair cell stereocilia

This study detects spontaneous calcium transients in hair cell stereocilia using fluorescent sensors and microscopy, showing they originate from mechanoelectrical transduction channels and occur in multiple stereocilia regions.

Synaptic properties of layer 6 auditory corticothalamic inputs in normal hearing and noise-induced hearing loss

The paper examines synaptic properties of corticothalamic inputs in normal hearing and noise-induced hearing loss, finding differences in synaptic strength and plasticity between thalamic subdivisions.

Effects of Cholesterol Modulation on Cisplatin-Induced Hearing Loss

This study shows that reducing systemic cholesterol, either through statins or genetic models, protects against cisplatin-induced hearing loss by preserving cochlear outer hair cells.

Speech-in-noise discriminability after noise exposure: Insights from a gerbil model of acoustic trauma

This study examines speech-in-noise discrimination in gerbils before and after acoustic trauma, finding improved vowel discrimination despite hearing loss and differential effects on consonant discrimination.

Cell-type-specific plasticity in synaptic, intrinsic, and sound response properties of deep-layer auditory cortical neurons after noise trauma

This study investigates cell-type-specific plasticity in deep-layer auditory cortical neurons after noise trauma, finding shifts in synaptic input and response properties in corticothalamic neurons.

CX3CR1 Fate-Mapping In Vivo Distinguishes Cochlear Resident and Recruited Macrophages After Acoustic Trauma

This study uses a CX3CR1 fate-mapping model to show that cochlear macrophages are heterogeneous in origin, distribution, and fate after acoustic trauma.