Circadian rhythm and melatonin

Human hormone seasonality

The paper analyzes health records to show seasonal patterns in human hormones, finding that effector hormones peak in winter-spring while upstream pituitary hormones peak in summer, suggesting a circannual clock mechanism.

Amplitude effects allow short jetlags and large seasonal phase shifts in minimal clock models

The paper shows that minimal clock models can reproduce essential circadian phenotypes like fast jetlag and seasonal shifts through amplitude effects and twist mechanisms.

Antagonistic Regulation of Circadian Output and Synaptic Development by the E3 Ubiquitin Ligase JETLAG and the DYSCHRONIC-SLOWPOKE Complex

The paper shows JETLAG and the DYSCHRONIC-SLOWPOKE complex antagonistically regulate circadian output and synaptic development in Drosophila.

Adult mice lacking VIP SCN neurons retain circadian locomotor behavior but exhibit dampened daily glucocorticoid rhythms

This study ablates VIP neurons in the adult SCN of mice and finds dampened glucocorticoid rhythms but preserved circadian locomotor behavior, suggesting distinct roles for VIP neurons in development and adulthood.

Gonads or body? Differences in gonadal and somatic photoperiodic growth response in two vole species.

The paper compares photoperiodic responses in gonadal and somatic growth between two vole species, finding species-specific differences in sensitivity and developmental programming of the photoperiodic neuroendocrine system.

No evidence for an S cone contribution to the human circadian response to light

The paper tests if S cones contribute to circadian light responses and finds no evidence, suggesting melanopsin is the sole driver.

Simple and complex interactions between sleep-wake driven and circadian processes shape daily genome regulatory dynamics in the mouse

This study examines how sleep deprivation affects gene expression and chromatin accessibility in mice, revealing long-term genomic regulatory changes.

Sirt7 regulates circadian phase coherence of hepatic circadian clock via a body temperature/Hsp70-Sirt7-Cry1 axis

This study identifies a novel body temperature/Hsp70-Sirt7-Cry1 axis that maintains circadian phase coherence in mouse liver by regulating Sirt7 activity.

Thermosensitive alternative splicing senses and mediates temperature adaptation in Drosophila

This study shows that temperature changes alter the splicing of the timeless gene in Drosophila, affecting TIM protein levels and activity through temperature-sensitive splicing isoforms.

Bayesian Modeling Reveals Ultrasensitivity Underlying Metabolic Compensation in the Cyanobacterial Circadian Clock

The paper uses Bayesian modeling to show that ultrasensitivity in KaiC phosphorylation, driven by differential KaiA binding to ATP/ADP states, enables metabolic compensation in the cyanobacterial circadian clock.

Cyclin Dependent Kinase 5 (CDK5) Regulates the Circadian Clock

This study identifies CDK5 as a kinase that regulates the mammalian circadian clock by phosphorylating PER2, facilitating its nuclear entry and maintaining circadian period.

Visual and non-visual properties of filters manipulating short-wavelength light

The paper introduces a framework to quantify visual and non-visual effects of short-wavelength light filters using factors like luminance, melanopsin activation, color shift, and gamut reduction.

Splice variants of DOMINO control Drosophila circadian behavior and pacemaker neuron maintenance

This study identifies DOM splice variants DOM-A and DOM-B as regulators of circadian behavior and sLNv maintenance in Drosophila by modulating pacemaker gene expression and PDF accumulation.

In silico identification of a molecular circadian system with novel features in the crustacean model organism Parhyale hawaiensis

The paper identifies circadian clock genes in Parhyale hawaiensis, finding missing orthologs of cryptochrome 1 and timeless and atypical CLOCK peptide features.

Pathological circadian rhythm states driven by CK2 and noise

The paper models circadian rhythm disruption in Drosophila using a CK2-Per interaction framework, identifying three pathological states driven by noise and system size fluctuations.

Dissection of central clock function in Drosophila through cell-specific CRISPR-mediated clock gene disruption

The paper uses CRISPR to disrupt clock genes in specific Drosophila neurons, showing that neither the morning nor evening oscillator alone is sufficient for circadian locomotor activity, indicating a distributed network function.

Neuron-specific knockouts indicate the importance of network communication to Drosophila rhythmicity

The paper shows that network communication is important for Drosophila circadian rhythms, with specific neuron groups relying on it for period determination.

A detailed graphical and computational model of the mammalian renal circadian clock

The paper constructs a computational model of the mammalian renal circadian clock and validates it against experimental data to understand its role in blood pressure regulation.

Light-mediated circuit switching in the Drosophila neuronal clock network

The paper identifies a light-mediated pathway in Drosophila that uses PDF-releasing lLNv neurons to adjust circadian rhythms to long day conditions.

MYC-associated factor MAX is an essential regulator of the clock core network

This study identifies MAX as a repressive component of the circadian clock core network, essential for maintaining circadian rhythms and balancing molecular clock elements.

Weak Coupling Between Intracellular Feedback Loops Explains Dissociation of Clock Gene Dynamics

The paper shows that weak coupling between feedback loops in circadian clocks leads to dissociated gene expression dynamics at the single-cell level.

Cellular properties of intrinsically photosensitive retinal ganglion cells during postnatal development

The paper characterizes the morphological and physiological properties of three ipRGC subtypes during postnatal development and finds they reach adult-like features at different times.

Systemic Commitments of the Context-Dependency; Basics of Elementary Coordination in Circadian Cycles

The paper examines how circadian rhythms influence coordination dynamics and biological functions, finding that circadian effects are consistent across day-night cycles and that disruptions may lead to physical complications.

Photoreceptor inputs to pupil control

The paper reanalyses existing data to confirm that melanopsin-weighted quantities improve pupil size modeling using Watson & Yellott's formula.

Low-dimensional Dynamics of Two Coupled Biological Oscillators

This study infers coupling and non-linear dynamics between circadian clocks and cell cycles from single-cell microscopy data, revealing temperature-independent, evolutionarily conserved phase-locked states.

ECHO: an Application for Detection and Analysis of Oscillators Identifies Metabolic Regulation on Genome-Wide Circadian Output

ECHO detects and analyzes oscillators in time-course genome-scale data, revealing metabolic regulation through circadian rhythms with changing amplitudes.

Circadian Oscillations Persist in Low Malignancy Breast Cancer Cells

The paper investigates circadian oscillations in breast cancer cells using luciferase reporter lines, finding persistent oscillations in low-grade MCF7 cells but not in high-grade MDA-MB-231 cells.

miR-210 controls the evening phase of circadian locomotor rhythms through repression of Fasciclin 2

This study identifies miR-210 as a regulator of evening circadian behavior in fruit flies by repressing Fasciclin 2.

A novel subtype of pineal projection neurons expressing melanopsin share a common developmental program with classical projection neurons

The paper identifies a new subtype of pineal projection neurons in zebrafish that express melanopsin and share developmental features with classical projection neurons.

Distinct ipRGC subpopulations mediate light’s acute and circadian effects on body temperature and sleep

The paper shows that a specific subpopulation of ipRGCs projecting to the SCN mediates light's acute effects on body temperature and sleep, while other ipRGCs are involved in circadian regulation.