Cellular Mechanics and Interactions

This paper develops a continuum framework to study stress anisotropy in 3D curved biological layers, showing how curvature and cell mechanics lead to irregular cellular shapes like scutoids.

The paper shows that a mechanogen gradient controls contractility during Drosophila gastrulation by regulating actomyosin contractility through Fog signaling.

This study shows that ECM maturation and cytoskeletal tension determine the strain threshold for stretch-induced calcium signaling in human tendon cells.

The paper investigates the interaction between Solo and LARG in response to substrate stiffness and finds that this interaction is required for actin polymerization.

This study shows that low-intensity vibrations cause nuclear motion and cytoskeletal changes in mesenchymal stem cells, independent of matrix strain, leading to transcriptional activation.

This study identifies Spdi, the Drosophila homolog of SPECC1L, as a non-muscle myosin II binding protein that regulates focal adhesion dynamics, linking its dysfunction to cranial neural crest cell migration defects.

The paper investigates how mechanical stress is dissipated in folded epithelia, revealing that calcium waves and nuclear tension changes coordinate this process.

This study identifies NHSL3 as a regulator of actin dynamics by interacting with Ena/VASP proteins and the Scar/WAVE complex, inhibiting Arp2/3 activity to promote cell migration.

This study uses 3D reconstructions and simulations to show that geometrical ratcheting stabilizes the shape of budding intestinal organoids through changes in tension and actomyosin reorganization.

This study shows elevated hydrostatic pressure affects VE-cadherin junctions via piezo-1, with effects dependent on shear stress duration and intensity.

This study investigates how profilin regulates lamellipodium protrusion by modulating the interactions between the Arp2/3 complex, capping protein, and Ena/VASP proteins.

This study identifies SH3BGRL proteins as non-enzymatic regulators of actin dynamics, promoting nucleation and inhibiting depolymerization through their thioredoxin fold structure.

This study investigates mechanical excitability in renewable active matter, showing that activity and turnover generate travelling waves and spatiotemporal chaos in systems like the cell cytoskeleton.

The paper shows that most actin subunits in lamellipodial networks come from membrane-associated polymerases, not directly from solution.

This study investigates how mitotic cells regulate plasma membrane tension using FliptR sensors and AFM measurements, revealing two actin-driven mechanisms involving hydrostatic pressure and protrusion forces.

This study identifies distinct morphomechanical features of prostate cancer-associated fibroblasts (CAFs) linked to patient outcomes and shows these features can be modulated by cancer treatments.

This study shows that ROS-induced actin filament severing increases polymerization in vitro but can lead to network disassembly beyond a threshold.

This study shows that Sp1 mechanotransduction enhances breast cancer cell invasion in response to combined ECM cues like stiffness, stress relaxation, and collagen density.

This paper develops a tissue-engineered model to study how physical cues like stiffness and axonal diameter affect oligodendrocyte myelination, finding that softer substrates promote differentiation while rigid ones maintain mature states.

The paper shows that nuclear contact and positioning enhance basement membrane invasion efficiency in C. elegans anchor cells.

This study identifies the NHSL1-A complex as a regulator of cell migration and chemotaxis by interacting with the Arp2/3 complex and modulating lamellipodia dynamics.

This study investigates how viscoelastic substrate properties influence cell migration, revealing transitions between sub-diffusive and super-diffusive behavior through a new glassy motor-clutch model.

The paper shows that mechanical fracturing of the cardiac extracellular matrix patterns delamination in the zebrafish heart, independent of biochemical signals.

This study shows mechanical strain activates EGFR-ERK signaling in epithelial cells via E-cadherin-induced ADAM17-mediated ligand shedding.

This study examines how epithelial cell polarity affects tissue tension in free-standing monolayers, showing that basal cortex tension drives elastic responses while apical regions exhibit hysteresis.

This paper develops a three-color Cascade-FRET system to measure force-dependent interactions between RIAM and vinculin in focal adhesions, revealing force-independent binding and tension-sensing capabilities.

This study shows prolonged shear stress induces fibroblast-to-myofibroblast transition through mechanical and biochemical changes, with lasting effects on cell morphology, adhesion, and migration.

This paper develops a mathematical model of bleb expansion to show that TalA regulates intracellular pressure by limiting membrane expansion during blebbing, resulting in smaller and less frequent blebs in its absence.

This study investigates how mechanical tension and cytoskeletal stiffening regulate cardiomyocyte contractility through a combined theoretical and experimental approach.

This study investigates the mechanical role of keratin cortex in epithelial cells by comparing keratin-deficient and wild-type cells under strain.