Fungal and yeast genetics research

Minor isozymes tailor yeast metabolism to carbon availability

The paper identifies two minor yeast isozymes, ACO2 and PYK2, that have distinct roles in adapting to carbon availability through differential expression and functional advantages under specific metabolic conditions.

A dataset to explore kinase control of environmental stress responsive transcription

The paper presents a dataset analyzing kinase activity and gene expression in yeast under environmental stress, revealing how kinases modulate stress responses.

Long Range Order and Short Range Disorder in Saccharomyces cerevisiae Biofilm

The paper analyzes transcriptome-wide expression patterns in Saccharomyces cerevisiae biofilm strains, finding global regulatory stability despite local expression changes.

Multiple layers of cryptic genetic variation underlie a yeast complex trait

The paper identifies 21 loci underlying a yeast colony phenotype, showing cryptic genetic variation is revealed by specific perturbations and environmental contexts.

Mitochondrial DNA and temperature tolerance in lager yeasts

The paper shows that the mitochondrial genome origin determines temperature tolerance in lager-brewing yeast hybrids.

Cell cycle inhibitor Whi5 records environmental information to coordinate growth and division in yeast

This study shows that Whi5 in yeast acts as an environmental indicator that coordinates cell growth and division by adjusting cell cycle entry based on environmental conditions.

Identification of 15 new bypassable essential genes of fission yeast

This study identifies 15 new bypassable essential genes in fission yeast through extragenic suppressor screening, showing that essentiality can be bypassed in some genes.

The regulation of HAD-like phosphatases by signaling pathways modulates cellular resistance to the metabolic inhibitor, 2-deoxyglucose

This paper identifies Dog1 and Dog2 as 2DG detoxication enzymes in yeast, showing their regulation by signaling pathways and their role in 2DG resistance, with implications for human cancer therapy.

Transcriptional profiling elucidates the essential role of glycogen synthase kinase 3 to fruiting body formation in Coprinopsis cinerea

This study uses RNA-Seq to show that GSK3 inhibition in Coprinopsis cinerea disrupts fruiting body formation by altering gene expression related to metabolism and cellular processes.

The genetic basis of mutation rate variation in yeast

This study identifies genetic variants affecting mutation rates in yeast by analyzing natural isolates and segregant progeny, finding heritability and specific genes involved in mutation rate variation.

Updating genome annotation for the microbial cell factory Aspergillus niger using gene co-expression networks

This study uses gene co-expression networks to infer functions for uncharacterized genes in Aspergillus niger, identifying four transcription factors involved in secondary metabolite synthesis.

Perturbations of transcription and gene expression-associated processes alter distribution of cell size values in Saccharomyces cerevisiae

The paper shows that gene expression and transcription-related processes influence cell size distribution in yeast by analyzing single-gene deletion strains.

Genetic basis of variation in heat and ethanol tolerance in Saccharomyces cerevisiae

This study identifies genetic variants in S. cerevisiae that affect ethanol and temperature tolerance, showing their interdependent nature.

A novel link between Cell Wall Integrity pathway and Flocculation, regulated by yeast Sen1 dependent interplay between Rlm1 and Tup1

The paper identifies a molecular link between the Cell Wall Integrity (CWI) pathway and flocculation in yeast, regulated by Sen1-mediated interaction between Rlm1 and Tup1.

Mitotic systemic genomic instability in yeast

The paper identifies systemic genomic instability in yeast, showing non-independent accumulation of loss-of-heterozygosity events across multiple chromosomes.

Methionine coordinates a hierarchically organized anabolic program enabling proliferation.

The paper identifies how methionine reprograms yeast metabolism to support proliferation by rewiring key metabolic pathways and co-opting a stress response regulator.

Master regulators of genetic interaction networks mediating statin drug response in Saccharomyces cerevisiae vary with genetic background

The paper identifies master regulators of genetic interaction networks mediating statin response in yeast, showing variability across genetic backgrounds.

Role of cis, trans, and inbreeding effects on meiotic recombination in Saccharomyces cerevisiae

The paper measures meiotic recombination rates in yeast strains and finds recombination correlates with sequence similarity and is reduced in homozygous genotypes.

Identification and in silico analysis of the origin recognition complex in the human fungal pathogen Candida albicans

The paper identifies putative ORC homologs in Candida albicans and analyzes their domain architecture and 3D structure to understand their role in DNA replication.

eQTL network analysis reveals that regulatory genes are evolutionarily older and bearing more types of PTM sites in Coprinopsis cinerea

The paper identifies regulatory genes in Coprinopsis cinerea using eQTL analysis and finds they are evolutionarily older and have more PTM sites than non-regulatory genes.

Sfp1 regulates transcriptional networks driving cell growth and division through multiple promoter binding modes

This study identifies Sfp1 as a master regulator of cell growth and division in yeast by coordinating gene expression through two distinct promoter binding modes.

Heavy metal sensitivities of gene deletion strains for ITT1 and RPS1A connect their activities to the expression of URE2, a key gene involved in metal detoxification in yeast

The paper identifies two yeast genes, ITT1 and RPS1A, whose deletion increases heavy metal sensitivity by affecting URE2 mRNA translation.

The Genome of the Human Pathogen Candida albicans is Shaped by Mutation and Cryptic Sexual Recombination

This study analyzes the genome of Candida albicans to show that mutation and cryptic sexual recombination drive its evolution, with non-random distribution of SNPs and LOH events.

Balance between mutually exclusive traits shifted by variants of a yeast transcription factor

The paper identifies DNA-binding preferences of Ste12 in yeast and shows how mutations shift its preference toward mating or invasion.

Transposable element insertions shape gene regulation and melanin production in a fungal pathogen

The paper identifies transposable element insertions as a mechanism regulating Zmr1 expression and melanin accumulation in the fungal pathogen Zymoseptoria tritici.

A genome-wide resource for high-throughput genomic tagging of yeast ORFs

The paper describes a C-SWAT library for high-throughput tagging of yeast ORFs and validates it by tagging the yeast proteome with fluorescent proteins.

Investigating the long-term stability of protein immunogen(s) for whole recombinant yeast-based vaccines

The paper investigates the long-term stability of heterologous protein antigens in yeast cells and proposes a strategy to assess their integrity.

Kinome expansion in the Fusarium oxysporum species complex driven by accessary chromosomes

This study compares kinomes of 12 Fusarium oxysporum isolates and seven ascomycete genomes, identifying kinase expansions linked to environmental sensing and host specificity.

Generating genomic platforms to study Candida albicans pathogenesis

The paper generates an ORFeome collection and associated tools for studying Candida albicans pathogenesis.

Single cell functional genomics reveals the importance of mitochondria in cell-to-cell variation in proliferation, drug resistance and mutation outcome

The paper investigates cell-to-cell variation in yeast by analyzing the impact of gene deletions on mitochondrial state and its effects on proliferation, drug resistance, and mutation outcomes.