Neurogenesis and neuroplasticity mechanisms

This study identifies p75NTR as an anti-migratory factor in cerebellar granule cell precursors by maintaining active RhoA levels during proliferation.

This study identifies that many molecules promoting oligodendrocyte formation inhibit cholesterol pathway enzymes, with a focus on EBP, and proposes a model for their mechanism.

The paper identifies a transcription factor network involving Gata2, Nkx2-2, and Skor2 that regulates the development of midbrain GABAergic neurons associated with REM sleep regulation.

The paper shows human neural progenitors form an ER diffusion barrier during cell division, enabling asymmetric segregation of damaged proteins.

This study identifies Dbx1 as a regulator of astrocyte development in the mouse spinal cord by modulating Notch signaling and influencing neuron-glial balance.

The paper uses morphology-based pseudotime and fate mapping to show cerebellar inhibitory interneurons diversify into two classes with within-class heterogeneity.

This study identifies Cd59 and inflammation as critical for Schwann cell development, showing that Cd59 deficiency leads to myelin defects and that inflammation inhibition restores normal development.

The paper shows that increasing neuronal activity in human cerebral spheroids increases new neurons and decreases new glial cells, with reduced miR-135a expression.

The paper shows that horizontal cells in the zebrafish retina use amoeboid-like migration to navigate crowded tissue and form the correct layer.

This study identifies reduced WNT signaling in Down syndrome progenitors, leading to fewer COUP-TFII+ interneurons and impaired neurogenesis.

This study investigates DDX3X syndrome using a mouse model, showing that DDX3X regulates cell cycle and translation in neural progenitors, leading to cortical malformations and neurodevelopmental issues.

This study uses in situ sequencing to map oligodendrocyte lineage progression across brain and spinal cord regions in juvenile and adult mice, revealing spatial and temporal heterogeneity.

This study identifies six signaling pathways regulating the proliferation and developmental potential of human neuroepithelial stem cells in vitro.

This study shows that Shh signaling regulates stellate cell pool size in the cerebellum, which is critical for dendritic inhibition and motor learning.

This study investigates how mechanical and chemical cues influence the migration of Cajal-Retzius cells in the developing neocortex, showing that mechanical properties and route stiffness affect their distribution.

The paper identifies input-specific mechanisms regulating the survival of two striatal interneuron subtypes during programmed cell death.

This study identifies an early wave of oligodendrogenesis in the human forebrain at PCW 8 using single-cell RNA-Seq and ATAC-Seq, supported by spatial gene expression analysis.

This study shows that increased adult hippocampal neurogenesis reduces CA1 neuronal activity during context fear memory retrieval and alters perineuronal net expression, potentially leading to memory forgetting.

The paper evaluates brain somatic mosaicism in the adult human to identify rules governing cellular distribution during embryogenesis.

The paper shows that contracting muscle conditioned media accelerates hippocampal neuronal maturation and astrocyte proliferation, with astrocytes mediating the effects on neuronal activity.

This study compares the efficiency and effects of tamoxifen injection versus chow administration in inducing recombination and altering adult hippocampal neurogenesis in mice.

This study shows that TDP-43 loss affects oligodendrocyte survival and myelination differently at various stages of maturation, leading to morphological defects and neurological impairments.

This study shows clemastine increases oligodendrocyte differentiation but impairs myelination during development, likely due to microglia-oligodendrocyte interactions.

The paper identifies VGF as a thalamus-derived factor essential for maintaining layer 4 neuron numbers in mouse sensory cortices, highlighting thalamocortical axons' role in shaping cortical cytoarchitecture through area-specific secretory protein supply.

This study shows that Vangl2 regulates adult hippocampal neurogenesis and cognitive flexibility in mice, with reduced Vangl2 leading to impaired memory and increased interference-based forgetting.

This study shows that oligodendrocyte precursor cells regulate axonal remodeling in the zebrafish visual system without forming myelin, affecting visual acuity.

This study shows that while most hypothalamic neurons develop normally without the H3K27me3 epigenetic mark, specific neuronal subtypes are sensitive to its loss.

This study shows that Pax6 loss affects neurite extension, axon initial segment properties, and electrophysiological function in developing mouse prethalamic neurons.

The paper identifies and characterizes lateral protrusions in neuroepithelial cells, showing they form a latticework regulated by WAVE1 and are involved in neurogenesis.

This study uses single-cell RNA-seq to show that mouse retinal ganglion cell precursors diversify into discrete types through gradual fate restriction after mitosis.