Genetics, Aging, and Longevity in Model Organisms

The paper shows that yeast spores age by gradually losing gene-expressing ability, leading to death when this ability is irreversibly lost.

SynergyAge curates genetic and lifespan data from animal models with multiple longevity-modulating interventions to explore synergistic and antagonistic gene interactions.

The paper shows that damage retention and early repair in yeast promote rejuvenation and longer healthy lifespans by reducing damage variability and stress susceptibility.

The paper investigates factors influencing yeast quiescence using defined media, revealing interactions between auxotrophy, nutrient availability, and signaling pathways.

This study identifies PQM-1 as a regulator of hypoxic survival in C. elegans by modulating lipid metabolism and oxygen consumption, with trade-offs between maternal and progeny survival.

This paper reviews rhesus macaques as a model for human ageing, showing shared gene regulatory signatures in immune ageing between macaques and humans.

The paper identifies compounds that mimic calorie restriction by inducing liver gene signatures similar to those observed under calorie restriction in mice and rats.

This study shows that polyploid cells accumulate in the ageing Drosophila brain and are more resistant to DNA damage-induced cell death than diploid cells.

The paper uses single-cell RNA-sequencing to show that caste transition in ants leads to glia remodeling associated with extended lifespan.

RNAAgeCalc calculates transcriptional age across tissues using age-related genes identified from GTEx and validates its predictive power using TCGA data.

The paper identifies SEM-4 as a transcription factor required for regulating oxidative stress response by activating skn-1c and phase II detoxification genes in C. elegans.

The paper shows that ADAM17-triggered TNF signaling in Drosophila retina protects against age-related lipid droplet-mediated degeneration by initially buffering ROS but later causing toxic lipid release.

The paper uses multidimensional phenotyping of C. elegans to predict lifespan and quantify health, showing that more features improve prediction accuracy.

This study shows that caloric restriction in Daphnia magna causes extensive gene expression changes, including a shift in haemoglobin isoform preference, similar to hypoxia responses.

The paper shows that interactions between chromatin silencing and mitochondrial pathways create an epigenetic landscape that determines cell fate during aging, and introduces a genetically engineered long-lived state.

The paper compiles healthspan-related gene pathways in C. elegans and humans using literature review and molecular interaction data, identifying common themes like transcription and lipids.

This study examines age-related changes in the transcriptome and translatome of mouse tissues, revealing U-shaped gene expression patterns and age-related declines in protein synthesis.

The paper identifies rare genetic variants associated with exceptional longevity through pedigree analysis and genomic screening in Utah populations.

This paper shows that CREB regulates reproductive aging in C. elegans by controlling a Hedgehog-related signaling factor, WRT-10, through the TGF-β Sma/Mab pathway in the hypodermis.

The paper identifies genetic mechanisms underlying diet-dependent lifespan and healthspan in D. melanogaster using GWAS and validates gene effects on lifespan and climbing ability.

This study shows that reduced proteasome activity in aging brains leads to ribosome stoichiometry loss and aggregation, increasing mortality risk in killifish.

The paper introduces an optimized competitive-aging method to identify gene-drug interactions affecting yeast chronological lifespan, revealing a link between protein glycosylation and metformin-induced lifespan extension.

This study shows that mutations in egl-9 and rhy-1 suppress the long-lived phenotype of vhl-1 mutants in C. elegans, indicating a VHL-1-independent role for EGL-9 and RHY-1 in longevity regulation.

The paper identifies a neuronal circuit in C. elegans that modulates hydrogen peroxide defenses based on sensory input and bacterial presence.

The paper identifies intragenic repeat expansions in yeast that influence chronological aging by altering cellular metabolism and environmental interaction.

This paper models the aging self-organization system using supervised learning to optimize aging networks and study molecular mechanisms of aging and related diseases.

The paper compares gene regulations in 'healthy' and 'common' aging using GTEx data to identify differences and connections with age-related diseases.

The paper shows that somatic mutation frequencies increase with age in human liver hepatocytes but are lower in liver stem cells and organoids.

The paper identifies diet-induced gene expression variation in Drosophila melanogaster using RNA-seq, revealing diverse pathways beyond the insulin/TOR pathway.