Cerebrospinal fluid and hydrocephalus

A choroid plexus apocrine secretion mechanism shapes CSF proteome and embryonic brain development

The paper shows that apocrine secretion by the choroid plexus affects CSF proteome and brain development in mice, with maternal stressors disrupting this process.

Structural characterization of SLYM - a 4th meningeal membrane

The paper identifies and characterizes SLYM, a potential fourth meningeal membrane, using imaging and histological analysis in mice.

SCO-spondin knockout mice exhibit small brain ventricles and mild spine deformation

This study generates Sspo knockout mice and finds reduced brain ventricle size but only minor spine curvature defects.

Cerebrospinal Fluid Flow Extends to Peripheral Nerves

This study demonstrates cerebrospinal fluid (CSF) flows into peripheral nerves, connecting the central and peripheral nervous systems through a continuous fluid system.

Astrocyte sensitivity to glymphatic shear stress is amplified by albumin and mediated by the interaction of sphingosine 1 phosphate with Piezo1

The paper investigates how astrocytes respond to glymphatic shear stress, finding that albumin enhances sensitivity through S1P-Piezo1 signaling.

The evolutionary conserved choroid plexus sustains the homeostasis of brain ventricles in zebrafish

This study identifies the zebrafish choroid plexus as evolutionarily conserved and critical for maintaining brain ventricle size and homeostasis through CSF secretion and transport.

Piezo1 agonist restores meningeal lymphatic vessels, drainage, and brain-CSF perfusion in craniosynostosis and aged mice

This study shows that Yoda1, a Piezo1 agonist, reduces intracranial pressure and improves CSF flow and meningeal lymphatic function in craniosynostosis and aged mice.

Image Analysis Techniques for In Vivo Quantification of Cerebrospinal Fluid Flow

The paper presents image analysis techniques for in vivo quantification of cerebrospinal fluid flow using fluorescent microspheres and discusses methods for measuring arterial diameter changes and applying these techniques to cervical lymphatic vessels.

Ependymocytes control cerebrospinal fluid flow to the peripheral organs through periaxonal pathway

The paper identifies a novel mechanism by which ependymocytes regulate cerebrospinal fluid (CSF) flow from the central nervous system to peripheral organs via the periaxonal pathway, mediated by serotonin signaling and F-actin polymerization.

Transport Pathways and Kinetics of Cerebrospinal Fluid Tracers in Mouse Brain Observed by Dynamic Contrast-Enhanced MRI

This study compares the transport kinetics and pathways of three contrast agents in mouse brains using DCE-MRI, showing size-dependent differences in glymphatic system function.

Human brain solute transport quantified by glymphatic MRI-informed biophysics during sleep and sleep deprivation

The paper quantifies human brain solute transport mechanisms using MRI data and computational modeling, showing that enhanced extracellular diffusion and advection are key during sleep.

Meningeal CSF transport is primarily mediated by the arachnoid and pia maters during development

This study tracks CSF tracer distribution in neonatal rodents to show that arachnoid and pia maters, not dura mater, primarily mediate CSF transport during development.

Neurofluid Coupling during Sleep and Wake States

This study investigates neurofluid coupling during wake and sleep states, finding strong coupling in both and identifying non-neuronal systemic influences across states.

Blood pressure lowering enhances cerebrospinal fluid efflux primarily via the lymphatic vasculature

This study shows that lowering blood pressure increases cerebrospinal fluid efflux through the lymphatic system, which can be blocked by lymphatic vessel ligation.

ASD mutation of Katnal2 impairs ependymal ciliary motion and causes hydrocephalus

The paper shows that an ASD-linked mutation in Katnal2 impairs ependymal ciliary motion, causing hydrocephalus and behavioral deficits in mice.

Perivascular spaces in Alzheimer's disease are associated with inflammatory, stress-related, and hypertension biomarkers

This study examines the relationship between perivascular spaces, cortisol, hypertension, and inflammation in cognitive impairment, finding significant associations and interactions.

A minimally-invasive method for serial cerebrospinal fluid collection and injection in rodents with high survival rates

This paper introduces a minimally-invasive method for collecting and injecting cerebrospinal fluid in rodents with high survival rates and rapid procedure times.

Ultrastructure of the brain waste-clearance pathway

The paper examines the ultrastructural pathways of brain waste clearance, highlighting the role of macrophages and arachnoid villi in transporting waste to the venous system.

Interrogation of dynamic glucose-enhanced MRI and fluorescence-based imaging reveals a perturbed glymphatic network in Huntington disease

This study uses MRI and fluorescence imaging to show impaired glymphatic function in a mouse model of Huntington disease, suggesting it as a potential biomarker and therapeutic target.

Sex-specific age-related changes in glymphatic function assessed by resting-state functional magnetic resonance imaging

The paper assesses sex-specific age-related changes in glymphatic function using resting-state fMRI in healthy aging participants, finding a decline after age 55, especially in females.

In Rhesus monkeys, CSF-contacting neurons are the only neurons present in the medullo-spinal peri-ependymal zone

The paper investigates the organization of the central canal region in Rhesus monkeys and identifies CSF-contacting neurons as the only neuronal elements present in this area.

Dual impact of PTEN mutation on CSF dynamics and cortical networks via the dysregulation of neural precursors and their interneuron descendants

This study shows PTEN mutations cause ventriculomegaly and cortical network dysfunction through neural precursor and interneuron dysregulation, with mTORC1 inhibition offering therapeutic potential.

Nocturnal increase in cerebrospinal fluid secretion as a regulator of intracranial pressure

The paper shows that intracranial pressure increases during the dark phase in humans and rats, linked to elevated cerebrospinal fluid secretion, partly due to increased choroid plexus transport activity.

Brain perivascular space imaging across the human lifespan

The paper examines age-related changes in perivascular spaces (PVS) using MRI data from a large cohort, showing age and sex influence PVS size and distribution across the lifespan.

Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation

This study examines how AQP4 deletion affects glymphatic function using diffusion MRI techniques, finding altered brain fluid dynamics and reduced glymphatic influx in AQP4 KO mice.

Intrathecal Cu-albumin PET reveals age-related decline of cerebrospinal fluid (CSF)-lymphatic efflux

The paper uses [64Cu]Cu-albumin PET to quantify age-related decline in CSF-lymphatic efflux in mice, showing slower clearance and reduced lymph node activity in aged mice.

The genetic background of hydrocephalus in a population-based cohort: implication of ciliary involvement

This study investigates genetic variants in hydrocephalus patients and finds associations with ciliopathies and autism spectrum disorder using the iPSYCH cohort.

Notch inhibition rescues TNF-α mediated block in multiciliated ependymal cell differentiation: Implications for hydrocephalus therapy

This study shows that TNF-α inhibits multiciliated ependymal cell differentiation by upregulating Notch pathway effectors, and that Notch inhibition rescues this process, suggesting a potential therapeutic target for hydrocephalus.

Cortical-wide impairment of glymphatic system after focal brain injury

This study examines the effects of focal brain injury on intracerebral circulation using a closed head injury model in mice, finding reduced circulation on both ipsilateral and contralateral sides one week post-injury.

Treatment of Hydrocephalus by Decreasing Inflammatory Cytokine Response Using GIT 27

This study shows that GIT 27 reduces astrocyte attachment and cytokine levels when used as a pre-treatment for shunt insertion.