Cerebrospinal fluid and hydrocephalus

Perivascular and parenchymal fluid characteristics are related to age and cognitive performance across the lifespan

This study examines age-related changes in perivascular and parenchymal fluid flow characteristics and their relationship with cognitive performance across development and aging.

The Spatial Patterns and Determinants of Cerebrospinal Fluid Circulation in the Human Brain

This study develops a framework to analyze CSF flow patterns using low-b dMRI and identifies factors influencing these patterns across different brain regions.

Kcnb1-Kcng4 axis regulates Scospondin secretion and Reissner fiber development

The paper shows Kv2.1 negatively regulates Scospondin secretion and Reissner fiber assembly in zebrafish through interactions with cholesterol and signaling pathways.

Lumped parameter simulations of cervical lymphatic vessels: dynamics of murine cerebrospinal fluid efflux from the skull

The paper models CSF drainage through cervical lymphatic vessels using a lumped parameter approach, revealing key physical characteristics and flow dynamics.

A subset of human choroid plexus epithelial cells exhibit mitochondrial eccentricity and distinct expression of the pigmentation-associated enzyme TYRP1

The paper identifies four subpopulations of human choroid plexus epithelial cells, including TYRP1-high cells with distinct molecular features related to pigmentation, cell cycling, and stress.

Lymphatic drainage of cerebrospinal fluid using lymph node seeker 64Cu-labeled Gram-negative bacterial extracellular vesicles PET

The paper quantifies the lymphatic drainage of cerebrospinal fluid in mice using 64Cu-labeled bacterial extracellular vesicles and identifies cervical lymph nodes as the primary drainage sites.

Dysregulated Neurofluid Coupling as a New Noninvasive Biomarker for Primary Progressive Aphasia

This study identifies reduced BOLD-CSF coupling as a biomarker for Primary Progressive Aphasia, linking glymphatic dysfunction to clinical and structural brain changes.

Enhancing glymphatic function with very low-intensity ultrasound via the transient receptor potential vanilloid-4-aquaporin-4 pathway

Very low-intensity ultrasound enhances glymphatic influx via the TRPV4-AQP4 pathway in astrocytes without causing brain damage.

Cilia dysfunction in the lateral ventricles after neonatal intraventricular hemorrhage does not lead to functional changes in cilia-based CSF flow networks

This study shows IVH reduces ciliated ependymal cells but does not disrupt cilia function or CSF flow networks in the lateral ventricles.

Neurodegenerative fluid biomarkers are enriched in human cervical lymph nodes

This study detects neurodegenerative biomarkers in human cervical lymph nodes, showing higher concentrations than plasma and age-related changes in phospho-Tau-181.

Vasomotor Pulsation Becomes a Driver of Cerebrospinal Fluid and Electrophysiological Dynamics in Sleeping Human Brain

The paper investigates how vasomotor pulsation drives cerebrospinal fluid and electrophysiological dynamics during sleep in humans.

Modeling CSF circulation and the glymphatic system during infusion using subject specific intracranial pressures and brain geometries

The paper develops a computational model to assess how brain geometry, intracranial pressure, and physiological parameters affect CSF circulation and glymphatic system function during infusion tests in iNPH patients and healthy controls.

Glymphatic system health in early Alzheimer's disease and its relationship to sleep, cognition and CSF biomarkers.

The paper investigates glymphatic system function in early Alzheimer's disease, finding associations between clearance efficiency, sleep, cognition, and CSF biomarkers, with unexpected relationships between biomarker levels and clearance rates.

Simulating the Impact of Tumor Mechanical Forces on Glymphatic Networks in the Brain Parenchyma

This study simulates how brain tumor mechanical forces affect glymphatic transport in the brain parenchyma, showing increased stress and strain reduce CSF flow rates.

Influence of the Glymphatic System on α-Synuclein Propagation: Role of Aquaporin-4 and the Dystrophin-Associated Protein Complex

This study investigates how the glymphatic system influences α-synuclein propagation and shows that AQP4 dysfunction may contribute to Parkinson's disease pathology.

Glymphatic clearance is enhanced during sleep

This study shows glymphatic clearance is increased during sleep and anesthesia and reduced during wakefulness, with tracer dose adjustments needed for accurate comparison across brain states.

Newly discovered base barrier cells provide compartmentalization of choroid plexus, brain and CSF

The paper identifies a novel fibroblast subtype in the choroid plexus that forms a barrier between the choroid plexus stroma, brain, and cerebrospinal fluid.

Aligning with the predecessors and counterarguments: A systematic review of the anatomical correlates for the newly discovered meningeal layer in the existing literature

This paper systematically reviews existing literature to determine if prior descriptions of a newly discovered meningeal layer exist, finding structural evidence in eight studies but limited clear descriptions.

Cerebrospinal Fluid Dynamics: Uncovering Alternative Blood Vessel Clearance Mechanisms

This study identifies a previously unrecognized CSF drainage pathway through blood vessels in the nasal mucosa, showing that CSF tracers can be drained via both lymphatic and venous routes in mice.

Ultrasonic cerebrospinal fluid clearance improves outcomes in hemorrhagic brain injury models

This paper demonstrates that low-intensity transcranial focused ultrasound improves outcomes in hemorrhagic brain injury models by clearing harmful substances via the meningeal lymphatic system.

The subcommissural organ regulates brain development via secreted peptides

The paper identifies three genes highly expressed in the subcommissural organ (SCO) and shows their ablation causes brain developmental defects, with peptide reintroduction rescuing these defects.

Transcranial direct current stimulation alters cerebrospinal fluid-interstitial fluid exchange in mouse brain

This study shows that tDCS increases CSF-ISF exchange and metabolic waste efflux in mice, linked to astrocytic IP3/Ca2+ signaling and delta wave changes.

Regional Glymphatic Dysfunction is linked to Spinocerebellar Ataxia Type 3 pathophysiology

This study links regional glymphatic dysfunction to SCA3 pathophysiology by showing impaired glymphatic markers and their correlation with disease severity.

Choroid plexus enlargement in acute neuroinflammation is tightly interrelated to the tyrosine receptor signalling

This study identifies tyrosine receptor signalling as linked to choroid plexus enlargement and CSF dynamics in MS neuroinflammation.

Non-invasive MRI of Blood-Cerebrospinal Fluid-Barrier Function: a Functional Biomarker of Early Alzheimer's Disease Pathology

This study uses MRI to measure blood-cerebrospinal fluid barrier function in a mouse model of Alzheimer's disease, finding increased water delivery through the barrier in early stages.

Design of a stem cell-based therapy for ependymal repair in hydrocephalus associated with germinal matrix hemorrhages

This study tests the use of neural stem cells and ependymal progenitors to repair ependymal damage in GMH/PHH, finding that EpPs in an MSC-conditioned environment are more effective.

The genetic basis of hydrocephalus: genes, pathways, mechanisms, and global impact

This review summarizes the genetic basis of hydrocephalus, including genes, pathways, and mechanisms, to highlight the complexity and global impact of its genetic contributions.

Molecular Signatures of Normal Pressure Hydrocephalus: A Large-scale Proteomic Analysis of Cerebrospinal Fluid

The paper identifies distinct proteomic signatures in cerebrospinal fluid of iNPH patients, highlighting downregulated synaptic markers and upregulated inflammatory markers, suggesting potential diagnostic biomarkers.

Cilia-mediated cerebrospinal fluid flow modulates neuronal and astroglial activity in the zebrafish larval brain.

This study investigates the role of cilia-mediated cerebrospinal fluid flow in zebrafish larval brain physiology, finding that cilia paralysis disrupts brain asymmetry and astroglial activity.

Cerebral Blood Volume Modulates Glymphatic Influx Through Extra-ventricular Cerebrospinal Fluid Volume

This study investigates how cerebral blood volume (CBV) affects glymphatic influx through changes in extra-ventricular cerebrospinal fluid volume across different anesthetic and awake conditions in mice.