Zebrafish Biomedical Research Applications

ZebraTrack: An Open-Source Object Detection Algorithm to Detect and Track Larval Zebrafish Motor Touch Responses

ZebraTrack automates the analysis of larval zebrafish touch response videos using YOLOv8n, extracting swim metrics and enabling high-throughput, error-free tracking.

Pharmacokinetics and efficacy of tank-water administered BRAF-inhibitor dabrafenib in a zebrafish model of BRAF-mutant melanoma

This study evaluates the pharmacokinetics and efficacy of tank-water administered dabrafenib in zebrafish with BRAF-mutant melanoma, showing rapid absorption, short half-life, and effective treatment with minimal toxicity.

Parkia javanica extracts exhibits tissue regeneration potential in Zebrafish (Danio rerio)

This study evaluates the tissue regeneration and antioxidant effects of Parkia javanica fruit and bark extracts in zebrafish, showing upregulated genes associated with regeneration and antioxidant capacity.

Jam2 Signaling and Hand2 Function are Required for the Formation of Organ-Specific Vascular Progenitors in Zebrafish

This study identifies Jam2 signaling and Hand2 function as essential for forming organ-specific vascular progenitors in zebrafish embryos, with implications for evolutionary conservation.

Evaluating anaesthetics for improving scientific research and welfare using larval zebrafish

The paper evaluates six anaesthetics for their efficacy and tolerability in larval zebrafish, identifying MS222 and quinaldine sulfate as most suitable for deep anaesthesia and etomidate for cardiovascular studies.

A zebrafish model of nicotinamide adenine dinucleotide (NAD+) deficiency-derived congenital disorders

The paper describes a zebrafish model of NAD+ deficiency to study congenital anomalies and their potential link to VACTERL association.

Non-invasive longitudinal imaging reveals aging-associated changes in neuroimmune cells in adult zebrafish

A 3D-printable device enables non-invasive, longitudinal imaging of adult zebrafish brains, revealing aging-associated changes in microglia dynamics.

Non-Destructive Larval Genotyping of Danio rerio for Mitochondrial and Nuclear DNA Genetics

This paper develops a non-destructive method for genotyping zebrafish larvae for mitochondrial and nuclear DNA, validated through PCR and sequencing, and shows its utility for gene editing studies.

Effects of stress coping styles and social defeat on zebrafish behaviour and brain transcriptomics

This study examines how boldness and shyness traits in zebrafish affect behaviour and brain gene expression after social defeat stress.

The Growth of Xiphophorus hellerii is Negatively Correlated with Colony Density

This study shows that lower colony density in Xiphophorus hellerii leads to greater growth compared to higher densities.

Genetic context of transgene insertion can influence neurodevelopment in zebrafish

The study investigates neurodevelopmental effects of a zebrafish Gal4 transgenic line, finding phenotypes linked to transgene insertion site rather than Gal4 toxicity.

Ketamine-induced NMDA receptor hypofunction alters social and locomotor behavior in adult zebrafish

This study examines the behavioral effects of ketamine in adult zebrafish, finding acute but not sustained changes in social and locomotor behavior.

Lifelong development of zebrafish gills: Asymmetries in early vascular patterning predict adult gill architecture

This study examines zebrafish gill development, showing early vascular asymmetries predict adult gill structure and reveal mechanisms of branching morphogenesis.

Imaging cellular activity simultaneously across all organs of a vertebrate reveals body-wide circuits

The paper introduces WHOLISTIC, a method to image cellular activity across all organs of a vertebrate, revealing body-wide circuits and responses to stimuli.

Angptl5 restricts primitive hematopoiesis by modulating retinoic acid signaling in zebrafish

This study identifies Angptl5 as a regulator of hematopoietic homeostasis in zebrafish by modulating retinoic acid signaling, leading to myeloid hyperplasia and erythroid expansion in mutants.

rapunzel5 is necessary for normal hematopoietic development in zebrafish

This study identifies rapunzel5 as essential for hematopoietic stem and progenitor cell development in zebrafish, affecting erythroid and myeloid differentiation.

Identifying in vivo genetic dependencies of melanocyte and melanoma development

This study uses a zebrafish model to identify genetic dependencies in melanocyte and melanoma development, revealing that gene loss can paradoxically promote aggressive phenotypes.

Larval zebrafish maintain elevation with multisensory control of posture and locomotion

This study shows larval zebrafish adjust their swimming and posture strategies based on light conditions after losing lateral line hair cells, demonstrating multisensory control of elevation.

Establishment of a transgenic strain for the whole brain calcium imaging in larval medaka fish (Oryzias latipes)

The paper develops a transgenic medaka strain for whole brain calcium imaging and demonstrates its use in detecting neural activity responses to stimuli.

Analysis of lhx8a, isl1, pax6a/b, calb2a and sst7 Reveals that Dopaminergic Neurons in the Zebrafish Subpallium Belong to the Extended Amygdala

The paper identifies subpallial dopaminergic neurons in zebrafish as part of the extended amygdala through developmental expression patterns of specific markers.

Paradise fish (Macropodus opercularis) as novel translational model for emotional and cognitive function

This study compares the behavioral responses of paradise fish and zebrafish in social and non-social tasks, finding that paradise fish show less social bias and more consistent behavior in individual-based assays.

Collective Behavior in Medaka Fish Depends on Discrete Kinematic States of Swimming Behavior

This study identifies three kinematic states in Medaka fish swimming and shows how social information processing varies across these states, leading to coordinated group behavior.

Volumetric imaging and computation to explore contractile function in zebrafish hearts

The paper develops a framework for real-time volumetric imaging of zebrafish hearts to study contractile dynamics at the cellular level.

Fishexplorer: A multimodal cellular atlas platform for neuronal circuit dissection in larval zebrafish

FishExplorer integrates multimodal brain data from larval zebrafish to enable circuit analysis and hypothesis generation.

Role of the 5HT2C receptor in anxiety-like behavior in zebrafish (Danio rerio)

This study examines the effects of 5-HT2C receptor agonists and antagonists on anxiety-like behaviors in zebrafish using novel tank and light-dark tests.

Distinct brain-wide neural dynamics predict social approach behavior

The paper shows that distinct brain-wide neural activity patterns predict social approach behavior in zebrafish, linking neural dynamics to behavioral variability.

Roles of the 5-HT1A receptor in zebrafish responses to potential threat and in sociality

This paper investigates the role of 5-HT1A receptors in zebrafish anxiety-like behavior and sociality using pharmacological treatments and behavioral assays.

Evolutionary Perspectives on Anxiety: Telencephalic Circuitry and the Anxiogenic Role of TrkB Signaling in Tuberous Sclerosis Complex

The paper investigates how TrkB signaling contributes to anxiety-like behavior in TSC zebrafish by analyzing telencephalic circuitry and shows that ANA-12 treatment rescues anxiety symptoms.

A connectomic resource for neural cataloguing and circuit dissection of the larval zebrafish brain

The paper presents a connectomic dataset of a larval zebrafish brain, enabling circuit analysis through synaptic and neuronal annotations.

Nervous system-wide single-cell morphology atlas of excitatory and inhibitory neurons in larval zebrafish

The paper creates a comprehensive atlas of larval zebrafish neuron morphology, including excitatory and inhibitory identities and connectivity patterns.