Cardiac Fibrosis and Remodeling

Decipher macrophage-fibroblast-cardiomyocyte signaling interactions associated with heart failure using deep graph neural network models and single-cell RNA-seq data

This study uses deep learning models and single-cell RNA-seq data to identify molecular targets and signaling pathways involved in macrophage-fibroblast-cardiomyocyte interactions in heart failure.

Deletion of the ion channel Trpm4 increases cardiac inflammatory markers and fibrosis after myocardial infarction in mice

This study shows that Trpm4 knockout in mice increases cardiac inflammation and fibrosis after myocardial infarction without improving survival.

A Canine Model of Chronic Ischemic Heart Failure

This paper develops a canine model of chronic ischemic heart failure by ligating different coronary artery branches to study survival and HF progression.

Defining Cardiac Recovery at Single Cell Resolution

The paper defines the cellular and transcriptional features of cardiac recovery using snRNA-seq, identifying RUNX1 downregulation as a key predictor and potential therapeutic target.

Loss of Acta2 in cardiac fibroblasts does not prevent myofibroblast differentiation or affect cardiac repair after myocardial infarction

MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation

This paper shows that MKK6 deficiency leads to cardiac dysfunction through hyperactivation of the MKK3-p38γ/δ-mTOR pathway, causing hypertrophy and fibrosis, and highlights potential cardiotoxicity of p38 inhibitors.

Endothelial TET2 Regulates Cardiac Remodeling by Modifying Endothelial-to-Mesenchymal Transition

This study shows TET2 regulates cardiac remodeling by inhibiting endothelial-to-mesenchymal transition, with vitamin C partially improving cardiac function.

Fibroblast Mechanotransduction Network Predicts Targets for Mechano-Adaptive Infarct Therapies

The paper predicts mechano-adaptive therapies for myocardial infarction by modeling fibroblast mechanotransduction and identifying 13 drug targets that modulate matrix accumulation in specific regions.

Nrg1/ErbB Signaling-Mediated Regulation of Fibrosis After Myocardial Infarction

This study investigates how M2-like macrophages regulate post-MI fibrosis through Nrg1/ErbB signaling, showing it suppresses fibroblast senescence and apoptosis.

Nicotinamide riboside kinase-2 inhibits JNK pathway and limits dilated cardiomyopathy in mice with chronic pressure overload

This study shows that NRK-2 protects against pressure overload-induced cardiac remodeling by inhibiting JNK pathway activation and mitochondrial dysfunction in mice.

Fibrosis protein-protein interactions from Google matrix analysis of MetaCore network

The paper uses Google matrix analysis of MetaCore network to predict protein-protein interactions involved in cardiac fibrosis in mouse and human tissues.

Discoidin Domain Receptor 2 regulates AT1R expression in Angiotensin II-stimulated cardiac fibroblasts via fibronectin-dependent Integrin-β1 signaling

This study identifies DDR2-mediated fibronectin regulation as a key mechanism for Angiotensin II-induced AT1R expression in cardiac fibroblasts through Integrin-β1 signaling.

A Transcriptional Switch Governing Fibroblast Plasticity Underlies Reversibility of Chronic Heart Disease

The paper identifies a reversible transcriptional switch in cardiac fibroblasts that governs fibroblast plasticity and contributes to chronic heart disease, with MEOX1 as a key regulator.

Extracellular Superoxide Dismutase (EC-SOD) Regulates Gene Methylation and Cardiac Fibrosis During Chronic Hypoxic Stress.

This study shows that EC-SOD overexpression reduces cardiac fibrosis and RASSF1A methylation in hypoxic mice.

Cardiovascular disease risk factors induce mesenchymal features and senescence in cardiac endothelial cells

This study shows that cardiovascular disease risk factors alter the transcriptome of cardiac endothelial cells, promoting mesenchymal features and senescence, with SERPINH1/HSP47 as a potential therapeutic target.

The landscape of accessible chromatin in quiescent and post-myocardial infarction cardiac fibroblasts

This study examines chromatin accessibility and gene expression in cardiac fibroblasts before and after myocardial infarction using ATAC-seq and RNA-seq, revealing correlations between promoter accessibility and gene expression, and identifying potential transcription factors involved in differential gene expression.

Cardiac fibroblast GSK-3α mediates adverse myocardial fibrosis via IL-11 and ERK pathway

This study identifies GSK-3α in cardiac fibroblasts as a mediator of myocardial fibrosis through the IL-11 and ERK pathway, showing its role in fibroblast activation and cardiac function improvement upon deletion.

Epigenetics and expression of key genes associated with cardiac fibrosis: NLRP3, MMP2, MMP9, CCN2/CTGF, and AGT

The paper examines the epigenetic regulation and expression of five fibrosis-related genes in cardiac fibrosis, identifying super-enhancers and enhancer chromatin features associated with their expression.

Protective Effects of Matrine on Acute Myocardial Hypertrophy Induced by Isoproterenol via Akt/mTOR/p70S6K/eIF4E Signaling Pathway in Rats

This study investigates how matrine reduces isoproterenol-induced myocardial hypertrophy in rats by modulating the Akt/mTOR/p70S6K/eIF4E signaling pathway.

Interleukin-35 pretreatment attenuates lipopolysaccharide-induced heart injury by inhibition of inflammation, apoptosis and fibrosis

This study shows that IL-35 pretreatment reduces LPS-induced heart injury by decreasing inflammation, apoptosis, and fibrosis through inhibiting NF-κBp65 and TGF-β1/Smad2/3 pathways.

Co-ordinated regulation of cell survival and cell cycle pathways by DDR2-dependent SRF transcription factor in cardiac fibroblasts

This study identifies DDR2-dependent SRF activation as a mechanism regulating cell survival and cell cycle progression in cardiac fibroblasts through ERK1/2 MAPK signaling.

Computational Model Predicts Paracrine and Intracellular Drivers of Fibroblast Phenotype After Myocardial Infarction

The paper develops a computational model to simulate fibroblast signaling and fibrosis after myocardial infarction, revealing how paracrine stimuli and signaling pathways drive fibroblast phenotype dynamics.

Role of microRNA-21 in hypertrophic cardiac remodeling

This study investigates the role of miR-21 in hypertrophic cardiac remodeling, showing that its suppression prevents remodeling by regulating PDCD4, AP-1, and TGF-β1 signaling.

CADHERIN-11 BLOCKADE REDUCES INFLAMMATION DRIVEN FIBROTIC REMODELING AND IMPROVES OUTCOMES AFTER MYOCARDIAL INFARCTION

This study shows that blocking CDH11 reduces inflammation-driven fibrosis and improves cardiac function after myocardial infarction in mice.

Dynamic chromatin targeting of BRD4 stimulates cardiac fibroblast activation

This study shows BRD4 promotes cardiac fibrosis by dynamically targeting chromatin and activating gene expression in fibroblasts, revealing a signaling pathway involved in heart failure.

Translational control of cardiac fibrosis

The paper identifies translational regulators of fibrogenic genes in human cardiac fibroblasts and shows their role in cardiac fibrosis through ribosome profiling and RNA-binding protein analysis.

Regression from pathological hypertrophy is sexually dimorphic and stimulus-specific

This study investigates sex differences and stimulus-specific mechanisms in the regression of pathological cardiac hypertrophy in mouse models.

Myocardin ablation in a cardiac-renal rat model

The paper examines MYOCD expression in DCM patients with and without renal disease and evaluates the effects of MYOCD silencing in a cardiorenal syndrome rat model.

The signaling mechanism of Hcy-induced atrial fibrosis mediated by TRPC3

This paper investigates how Hcy-induced atrial fibrosis is mediated by TRPC3 and SIRT1 interactions, showing increased fibrosis and TRPC3 expression in high-Hcy conditions.

The administration of high-mobility group box 1 fragment prevents deterioration of cardiac performance by enhancement of bone marrow mesenchymal stem cell homing in the delta-sarcoglycan-deficient hamster

This study shows that administering HMGB1 fragment improves cardiac function and reduces fibrosis in a hamster model of dilated cardiomyopathy by enhancing stem cell homing.