Axon Guidance and Neuronal Signaling

PlexinA4-Semaphorin3A mediated crosstalk between main cortical interneuron classes is required for superficial interneurons lamination

The paper shows that PlexinA4-Semaphorin3A signaling between deep and superficial cortical interneurons regulates their laminar positioning in the developing neocortex.

Characterizing the diverse cells that associate with the developing commissures of the zebrafish forebrain

The paper identifies and characterizes diverse cell types associated with commissure formation in zebrafish forebrain development.

Activity-dependent refinement of nasal retinal projections drives topographic map sharpening in the teleost visual system

This study uses a new transgenic zebrafish model to show that activity-dependent refinement of nasal retinal projections sharpens the antero-posterior retinotopic map in real-time.

EphA7 Isoforms Differentially Regulate Cortical Dendrite Development

This study identifies how two EphA7 isoforms differentially regulate cortical dendrite development through distinct signaling mechanisms.

The molecular logic of synaptic wiring at the single cell level

This study identifies a homeo-immunoglobulin code that specifies single-cell specific connections between motoneurons and target muscles through combinatorial immunoglobulin domain proteins.

Achieving functional neuronal dendrite structure through sequential stochastic growth and retraction

The paper investigates dendrite development in Drosophila c1vpda neurons, showing that sequential growth and stochastic retraction balance structural and functional requirements.

Zic2 abrogates an alternative Wnt signaling pathway to convert axon attraction into repulsion

The paper identifies an alternative Wnt signaling pathway regulated by Zic2 that mediates axon repulsion by modulating β-catenin phosphorylation and Eph signaling.

Synaptic specificity is collectively determined by partner identity, location and activity

The paper investigates how synaptic connections in Drosophila are formed through partner-derived cues, global positional cues, and synaptic activity, showing that all three contribute to proper circuit assembly.

Actin-based protrusions lead microtubules during stereotyped axon initiation in spinal neurons in vivo

The paper shows that axon initiation in spinal neurons occurs at a stereotyped position in vivo, independent of microtubule dynamics and laminin cues.

Myosin X interaction with KIF13B, a crucial pathway for Netrin-1-induced axonal development

The paper shows that Myo X and KIF13B form a pathway essential for Netrin-1-induced axon development in mouse neocortex.

Minimal structural elements required for midline repulsive signaling and regulation of Drosophila Robo1

This study identifies the minimal ectodomain structure of Drosophila Robo1 required for Slit binding and midline repulsive signaling, showing that Ig1 plus one additional domain is sufficient for full function.

On the role of photoreceptor identity in controlling accurate wiring of the Drosophila visual circuit

This study investigates how photoreceptor identity influences axon extension velocity and circuit formation in Drosophila.

Autophagy is required for midbrain dopaminergic axon development and their responsiveness to guidance cues

This study shows that autophagy is essential for midbrain dopaminergic axon development and responsiveness to guidance cues, with knockout of autophagy genes causing axonal swellings and impaired branching.

The branching code: a model of actin-driven dendrite arborisation

The paper develops a computational model to explain dendrite branchlet morphology in Drosophila neurons by analyzing actin-modulatory protein roles and dynamics.

New insights on the modelling of the molecular mechanisms underlying neural maps alignment in the midbrain

The paper validates a computational model of visual map alignment in the midbrain using a mouse model and proposes a new quantification method for map alignment.

Fmn2 regulates growth cone motility by mediating a molecular clutch to generate traction forces

This study identifies Fmn2 as a molecular clutch that regulates growth cone motility by coupling actin dynamics to the extracellular matrix through point contact adhesion complexes.

An autism-associated calcium channel variant causes defects in neuronal polarity and axon termination in the ALM neuron of C. elegans

This study shows that an autism-associated CACNA1C variant disrupts neuronal polarity and axon termination in C. elegans ALM neurons.

EPH tyrosine kinase receptors regulate epithelial morphogenesis and phosphorylate the PAR-3 scaffold protein to modulate downstream signaling networks

This study identifies novel effector proteins of EPH receptors and shows they regulate cell polarity and morphogenesis through PAR-3 and CSK signaling.

CAP1 and cofilin1 cooperate in neuronal actin dynamics, growth cone function and neuron connectivity

The paper identifies CAP1 as a novel actin regulator in growth cones that is critical for neuron connectivity and function.

Deterministic and stochastic rules of branching govern dendritic morphogenesis of sensory neurons

The paper investigates how deterministic and stochastic mechanisms shape dendritic branching in Drosophila neurons, finding that primary branches grow deterministically while secondary branches exhibit stochastic behavior influenced by geometric feedback.

A developmental stretch-and-fill process that optimises dendritic wiring

The paper develops a mathematical model of dendritic growth that optimizes wiring efficiency and space-filling through two complementary strategies.

Modular and distinct PlexinA4/Farp2/Rac1 signaling controls dendrite morphogenesis

This study identifies a novel Sema3A-Nrp1/PlxnA4/FARP2/Rac1 signaling pathway that specifically controls dendritic morphogenesis but not axon repulsion in cortical neurons.

NMDA receptors control cortical axonal projections via EPHRIN-B/EPHB signaling

This study shows that NMDA receptors, specifically NR2B-containing ones, control callosal axonal projections in the primary somatosensory cortex through interactions with EPHRIN-B/EPHB, independent of ion channel function.

Multicellular rosettes organize neuropil formation

The paper shows multicellular rosettes organize the nerve ring neuropil in C. elegans by guiding axon outgrowth and structural formation.

Regulation of nerve growth and patterning by cell surface protein disulphide isomerase

This study identifies protein disulphide isomerase as a key mediator of axon repulsion barriers in somites, showing its role in nitric oxide signaling and growth cone regulation.

The AMPK-related kinase NUAK1 controls cortical axons branching though a local modulation of mitochondrial metabolic functions

This study shows NUAK1 regulates cortical axon branching by modulating mitochondrial metabolism and positioning, with functional rescue observed through mitochondrial function upregulation.

A point mutation in Ttc26 causes lumbar spinal cord fusion and synchronous hind-limb locomotion in hop mice

Role of Drosophila Rap/Fzr (DCdh1) in Retinal Axon Targeting and its Interactions with Loco and Liprin-alpha

This paper investigates the role of Rap/Fzr in Drosophila retinal axon targeting and its interactions with Loco and Liprin-alpha, showing defects in axon projection in mutants and enhanced phenotypes in double mutants.

Tuba1a is uniquely important for axon guidance through midline commissural structures

The paper shows that reduced Tuba1a impairs axon guidance but supports neuronal migration, revealing TUBA1A's role in microtubule dynamics during neurodevelopment.

Interplay between axonal Wnt5-Vang and dendritic Wnt5-Drl/Ryk signaling controls glomerular patterning in the Drosophila antennal lobe

The paper shows that Wnt5 signaling through Vang and Drl/Ryk in Drosophila ORNs and PNs controls the rotation of DA1/VA1d glomeruli during antennal lobe development.