Axon Guidance and Neuronal Signaling

Endothelial Semaphorin 3fb regulates Vegf pathway-mediated angiogenic sprouting

This study identifies Sema3fb's role in modulating VEGF signaling to regulate endothelial sprouting during vascular development.

The Slit-binding Ig1 domain is required for multiple axon guidance activities of Drosophila Robo2

This study shows that the Slit-binding Ig1 domain of Drosophila Robo2 is essential for midline repulsion and lateral axon pathway formation, and its removal disrupts these functions.

Development of motor neurons and motor activity in zebrafish requires F-actin nucleation by Fmn2b

This study shows that Fmn2b is essential for motor neuron development and function in zebrafish, with loss-of-function leading to motor deficits and impaired axon branching.

The CATP-8/P5A-type ATPase functions in multiple pathways during neuronal patterning

This study identifies the catp-8/P5A-ATPase as a regulator of neuronal patterning in C. elegans, showing its role in dendrite morphogenesis, axon guidance, and neuronal migration through multiple genetic pathways.

Vinculin mediated axon growth requires interaction with actin but not talin

This study shows that vinculin's tail domain affects neuronal migration and axon growth through actin interactions, independent of talin.

Neuronal post-developmentally acting SAX-7S/L1CAM can function as cleaved fragments to maintain neuronal architecture in C. elegans

This study shows that cleaved SAX-7S fragments, not full-length protein, maintain neuronal architecture in C. elegans after development.

Natural loss of function of ephrin-B3 shapes spinal flight circuitry in birds

This study shows that the loss of ephrin-B3 function in birds shapes spinal flight circuitry by enabling synchronous wing flapping through altered midline signaling.

Reciprocal repulsions instruct the precise assembly ofparallel hippocampal networks

The paper shows that reciprocal repulsions between Teneurin-3 and Latrophilin-2 guide the assembly of parallel hippocampal networks during development.

Syntaxin-1 is necessary for UNC5/Netrin-1-dependent macropinocytosis and chemorepulsion

The paper shows that syntaxin-1 is required for UNC5/Netrin-1-dependent macropinocytosis and chemorepulsion in axonal guidance.

R7 photoreceptor axon targeting depends on the relative levels of lost and found expression in R7 and its synaptic partners

The paper shows that Loaf protein levels in R7 photoreceptors and their synaptic partners determine axon targeting accuracy in Drosophila.

Blood vessels regulate primary motor neuronal pathfinding in zebrafish via exosome contained microRNA-22

This study shows that miRNA-22a in blood vessels guides motor neuron pathfinding in zebrafish via exosomes and regulates vascular and neuronal patterning.

BMP signaling interferes with optic chiasm formation and retinal ganglion cell pathfinding in zebrafish

This study shows that BMP signaling disrupts optic chiasm formation and retinal ganglion cell (RGC) pathfinding in zebrafish by affecting midline guidance cues and optic stalk morphogenesis.

Quantitative profiling of axonal guidance proteins during the differentiation of human neurospheres

This study quantifies proteomic changes during human neurosphere differentiation, identifying upregulated axon guidance pathways and a functional assay for neurite outgrowth.

The DCC receptor regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation

This study shows that DCC and NTN1 regulate astroglial development and interhemispheric fissure remodeling, essential for corpus callosum and hippocampal commissure formation.

Semaphorin3F Drives Dendritic Spine Pruning through Rho-GTPase Signaling

This study identifies Sema3F's role in dendritic spine pruning through Rho-GTPase signaling pathways in cortical neurons.

High-Throughput Kinase Inhibitor Screening Reveals Roles for Aurora and Nuak Kinases in Neurite Initiation and Dendritic Branching

The paper screens 493 kinase inhibitors to identify roles of Aurora and Nuak kinases in neurite initiation and dendritic branching using Neuro2a cells and primary cortical neurons.

Slit2 is necessary for optic axon organization in the zebrafish ventral midline

This study characterizes the role of Slit2 in optic axon organization in zebrafish by analyzing a null mutant and showing defects in axon sorting at the optic chiasm and proximal tract.

Transneuronal Dpr12/DIP-δ interactions facilitate compartmentalized dopaminergic innervation of Drosophila mushroom body axons

Robo recruitment of the Wave Regulatory Complex plays an essential and conserved role in midline repulsion

This study identifies the WRC as a conserved effector of Robo signaling in axon repulsion across species.

Lumican regulates cervical corticospinal axon collateralization via non-autonomous crosstalk between distinct corticospinal neuron subpopulations

The paper identifies Lumican as a factor regulating axon collateralization in cervical corticospinal neurons through inter-neuronal crosstalk.

Semaphorin 3C attracts MGE-derived cortical interneurons in the deepmigratory stream guiding them into the developing neocortex

The paper investigates the role of Sema3C in guiding MGE-derived cortical interneurons during migration, showing that Nrp1-expressing interneurons are attracted to Sema3C gradients.

Glial insulin regulates cooperative or antagonistic Golden goal/Flamingo interactions during photoreceptor axon navigation

The paper shows glial insulin modulates Gogo phosphorylation, which controls R8 axon navigation in Drosophila by switching between recognition and suppression of Flamingo interactions.

Endoglycan plays a role in axon guidance and neuronal migration by negatively regulating cell-cell adhesion

This study shows that Endoglycan negatively regulates cell-cell adhesion, affecting axon guidance and neuronal migration in the central nervous system.

The Collagens DPY-17 and SQT-3 Direct Anterior-Posterior Migration of the Q Neuroblasts in C. elegans.

This study identifies DPY-17 and SQT-3 Collagens as regulators of left-right asymmetric migration of Q neuroblasts in C. elegans.

The Pebble/Rho1/Anillin pathway controls polyploidization and axonal wrapping activity in the glial cells of the Drosophila eye

The paper investigates the role of the Pebble/Rho1/Anillin pathway in glial cell proliferation and polyploidization in Drosophila eye development, showing it prevents large polyploid glial cells but is not required for axonal wrapping.

Conserved and divergent aspects of Robo receptor signaling and regulation between Drosophila Robo1 and C. elegans SAX-3

This study compares midline repulsive signaling of Drosophila Robo1 and C. elegans SAX-3 using transgenic expression, showing SAX-3 can signal repulsion but less efficiently than Robo1.

HTT is a repressor of ABL activity required for APP induced axonal growth

The paper shows HTT represses ABL activity, which is necessary for axonal growth in Drosophila mushroom bodies.

Axon guidance at the midline - a live imaging perspective

The paper describes a spinal cord preparation enabling live imaging of single axons navigating midline choice points, revealing dynamic interactions with the floor plate.

Cellular Bases of Olfactory Circuit Assembly Revealed by Systematic Time-lapse Imaging

The paper uses time-lapse imaging in Drosophila to study how olfactory receptor neurons target axons to specific glomeruli, revealing dynamics of branching and bilateral interactions.

Loss of floor plate Netrin-1 impairs midline crossing of corticospinal axons and leads to mirror movements

This study shows that loss of floor plate Netrin-1 disrupts corticospinal tract midline crossing in mice, causing mirror movements similar to human congenital conditions.