Cancer-related gene regulation

Chimeric PRMT6 protein produced by an endogenous retrovirus promoter regulates cell fate decision in mouse preimplantation embryos

The paper identifies a chimeric PRMT6 protein produced by MERVL in mouse embryos that promotes cell proliferation and differentiation, differing from the canonical PRMT6 protein.

SETDB1 Triple Tudor Domain Ligand, (R,R)-59, Promotes Methylation of Akt1 in Cells

The paper shows that (R,R)-59, a SETDB1 ligand, enhances SETDB1-mediated methylation of Akt1 and promotes cell proliferation.

E2F1 methylation by SETD6 regulates SETD6 expression via positive feedback mechanism

The paper identifies a positive feedback loop where SETD6 methylates E2F1 at K117, enhancing SETD6 expression, and shows that this methylation is critical for maintaining SETD6 levels.

PRMT5 links lipid metabolism to contractile function of skeletal muscles

This study shows PRMT5 links lipid metabolism to skeletal muscle function by regulating SREBP1a and ATGL through epigenetic mechanisms.

Asymmetric dimethylation of Ribosomal S6 Kinase 2 regulates its cellular localisation and pro-survival function

This study identifies asymmetric dimethylation of S6K2 by PRMT1, PRMT3, and PRMT6 as a mechanism regulating its nuclear localization and pro-survival function in cancer.

The T1150A cancer mutant of the protein lysine dimethyltransferase NSD2 can introduce H3K36 trimethylation

The paper shows that the T1150A mutation in NSD2 leads to hyperactivity and H3K36 trimethylation, suggesting a role in leukemia.

Arginine methylation of Puf4 drives diverse protein functions

This study shows that arginine methylation of Puf4 regulates its functions in post-transcriptional gene regulation in Cryptococcus neoformans.

ProMetheusDB: an in-depth analysis of the high-quality human methyl-proteome

The paper presents a high-quality human methyl-proteome dataset generated using hmSILAC and a machine learning tool, showing improved identification of methyl-peptides and novel histone methylation marks.

A chemical biology toolbox to investigate in-cell target engagement and specificity of PRMT5-inhibitors

The paper develops chemical biology assays to assess PRMT5 inhibitor target engagement and selectivity, revealing SAM's role in inhibitor binding and confirming the specificity of GSK3326595.

Discovering the N-terminal Methylome by Repurposing of Proteomic Datasets

This paper identifies N-terminal methylated peptides in yeast and humans by reanalyzing proteomic datasets, revealing novel substrates and non-canonical motifs.

Transcriptomic and proteomic regulation through abundant, dynamic, and independent arginine methylation by Type I and Type II PRMTs

The paper investigates the substrate preferences and functional consequences of Type I and II PRMTs by inhibiting them in A549 cells and analyzing proteomic and transcriptomic changes.

Prmt5 promotes vascular morphogenesis independently of its methyltransferase activity.

This study shows Prmt5 supports vascular development by regulating gene expression through chromatin looping as a scaffold, independent of its methyltransferase activity in zebrafish.

Arginine Methylation Regulates SARS-CoV-2 Nucleocapsid Protein Function and Viral Replication

This study shows that arginine methylation of SARS-CoV-2 N protein by PRMT1 is essential for RNA binding and suppression of stress granules, and inhibiting this methylation reduces viral replication.

Large-scale identification of protein histidine methylation in human cells

The paper identifies histidine methylation sites in human cells using proteomic data and reports their prevalence, localization, and functional associations.

A systematic survey of PRMT interactomes reveals the key roles of arginine methylation in the global control of RNA splicing and translation

The paper systematically identifies PRMT interactomes and shows arginine methylation regulates RNA splicing and translation by affecting ribosome assembly and cell growth.

Global analysis of protein arginine methylation

The paper develops an NMR-based method to quantify global protein arginine methylation levels across various biological samples and demonstrates its prevalence and modulation in health and disease.

Deep protein methylation profiling by combined chemical and immunoaffinity approaches reveals novel PRMT1 targets

The paper develops a combined chemical and immunoaffinity approach to profile protein methylation, identifying novel PRMT1 targets and revealing dynamic interactions between methyltransferases.

Post-translational epigenetics: PRMT7 regulates RNA-binding capacity and protein stability to control Leishmania parasite virulence

The paper identifies PRMT7 as an epigenetic regulator in Leishmania that modifies RNA-binding proteins, affecting mRNA stability and virulence.