Cancer-related gene regulation

Differential histone tail citrullination by protein arginine deiminases observed via NMR spectroscopy

This study identifies PAD1-4 citrullination sites in histone tails using NMR spectroscopy, revealing differential specificity and conformational effects in nucleosomes.

Arginine methylation coordinates with phosphorylation to regulate NADP+ synthesis

This study identifies PRMT6-mediated arginine methylation of NADK that suppresses its kinase activity and NADP+ synthesis, revealing a regulatory mechanism involving coordination with Akt phosphorylation and implications for cancer progression.

Acquired resistance to the PRMT5 inhibitor confers collateral sensitivity to MEK inhibition in MTAP-null non-small cell lung cancer

The paper identifies collateral sensitivity to MEK inhibition in MTAP-null NSCLC cells that develop resistance to PRMT5 inhibitors.

PRMT5-Mediated Arginine Methylation of HSP90AA1 Drives Esophageal Squamous Cell Carcinoma Progression

This study identifies PRMT5-mediated arginine methylation of HSP90AA1 as a driver of ESCC progression and shows that targeting this axis has therapeutic potential.

PRMT5-mediated histone methylation regulates alternative splicing via MECP2-PTBP1 to promote EMT in breast cancer hypoxia

Oligomerization of PRMT1 Regulated RNA-Binding Protein Cascade Promotes Pancreatic Ductal Adenocarcinoma

This study identifies PRMT1 oligomerization as critical for its function in pancreatic ductal adenocarcinoma by revealing its structural basis and functional impact on RNA-binding proteins.

The PRMT5-splicing axis is a critical oncogenic vulnerability that regulates detained intron splicing

The paper identifies PRMT5 inhibition as inducing detained introns and shows their role in cancer vulnerability through conserved gene regulation across species.

Potent and Selective SETDB1 Covalent Negative Allosteric Modulator Reduces Methyltransferase Activity in Cells

The paper identifies UNC10013, a covalent ligand targeting SETDB1's 3TD domain, which reduces methyltransferase activity and shows selectivity in cells.

SETD8 inhibition targets cancer cells with increased rates of ribosome biogenesis

This study identifies novel SETD8 inhibitors and shows their toxicity correlates with ribosome biogenesis regulators, suggesting a biomarker for targeted cancer therapy.

Chimeric PRMT6 protein produced by an endogenous retrovirus promoter regulates cell fate decision in mouse preimplantation embryos

The paper identifies a chimeric PRMT6 protein produced by MERVL in mouse embryos that promotes cell proliferation and differentiation, differing from the canonical PRMT6 protein.

SETDB1 Triple Tudor Domain Ligand, (R,R)-59, Promotes Methylation of Akt1 in Cells

The paper shows that (R,R)-59, a SETDB1 ligand, enhances SETDB1-mediated methylation of Akt1 and promotes cell proliferation.

PRMT5 links lipid metabolism to contractile function of skeletal muscles

This study shows PRMT5 links lipid metabolism to skeletal muscle function by regulating SREBP1a and ATGL through epigenetic mechanisms.

Asymmetric dimethylation of Ribosomal S6 Kinase 2 regulates its cellular localisation and pro-survival function

This study identifies asymmetric dimethylation of S6K2 by PRMT1, PRMT3, and PRMT6 as a mechanism regulating its nuclear localization and pro-survival function in cancer.

The T1150A cancer mutant of the protein lysine dimethyltransferase NSD2 can introduce H3K36 trimethylation

The paper shows that the T1150A mutation in NSD2 leads to hyperactivity and H3K36 trimethylation, suggesting a role in leukemia.

ProMetheusDB: an in-depth analysis of the high-quality human methyl-proteome

The paper presents a high-quality human methyl-proteome dataset generated using hmSILAC and a machine learning tool, showing improved identification of methyl-peptides and novel histone methylation marks.

Discovering the N-terminal Methylome by Repurposing of Proteomic Datasets

This paper identifies N-terminal methylated peptides in yeast and humans by reanalyzing proteomic datasets, revealing novel substrates and non-canonical motifs.

Transcriptomic and proteomic regulation through abundant, dynamic, and independent arginine methylation by Type I and Type II PRMTs

The paper investigates the substrate preferences and functional consequences of Type I and II PRMTs by inhibiting them in A549 cells and analyzing proteomic and transcriptomic changes.

Prmt5 promotes vascular morphogenesis independently of its methyltransferase activity.

This study shows Prmt5 supports vascular development by regulating gene expression through chromatin looping as a scaffold, independent of its methyltransferase activity in zebrafish.

Arginine Methylation Regulates SARS-CoV-2 Nucleocapsid Protein Function and Viral Replication

This study shows that arginine methylation of SARS-CoV-2 N protein by PRMT1 is essential for RNA binding and suppression of stress granules, and inhibiting this methylation reduces viral replication.

Large-scale identification of protein histidine methylation in human cells

The paper identifies histidine methylation sites in human cells using proteomic data and reports their prevalence, localization, and functional associations.

A systematic survey of PRMT interactomes reveals the key roles of arginine methylation in the global control of RNA splicing and translation

The paper systematically identifies PRMT interactomes and shows arginine methylation regulates RNA splicing and translation by affecting ribosome assembly and cell growth.

Global analysis of protein arginine methylation

The paper develops an NMR-based method to quantify global protein arginine methylation levels across various biological samples and demonstrates its prevalence and modulation in health and disease.

Deep protein methylation profiling by combined chemical and immunoaffinity approaches reveals novel PRMT1 targets

The paper develops a combined chemical and immunoaffinity approach to profile protein methylation, identifying novel PRMT1 targets and revealing dynamic interactions between methyltransferases.