Cancer-related gene regulation

Targeting PRMT5 Across Cancers and AI-Driven Discovery of Candidate Compounds

The paper identifies PRMT5 as a cancer target, uses multi-omics and machine learning to screen compounds, and identifies a potential inhibitor with high docking scores.

PRMT5 inhibition induces a histone methylation switch that drives chromatin plasticity, drug resistance, and metastatic progression

This study shows PRMT5 inhibition causes splicing defects and epigenetic changes leading to drug resistance and metastatic progression in lung adenocarcinoma.

Differential histone tail citrullination by protein arginine deiminases observed via NMR spectroscopy

This study identifies PAD1-4 citrullination sites in histone tails using NMR spectroscopy, revealing differential specificity and conformational effects in nucleosomes.

Arginine methylation coordinates with phosphorylation to regulate NADP+ synthesis

This study identifies PRMT6-mediated arginine methylation of NADK that suppresses its kinase activity and NADP+ synthesis, revealing a regulatory mechanism involving coordination with Akt phosphorylation and implications for cancer progression.

Acquired resistance to the PRMT5 inhibitor confers collateral sensitivity to MEK inhibition in MTAP-null non-small cell lung cancer

The paper identifies collateral sensitivity to MEK inhibition in MTAP-null NSCLC cells that develop resistance to PRMT5 inhibitors.

Protein arginine-methyltransferase 1 (PRMT1): a new pharmacological target in cholangiocarcinoma

This study identifies PRMT1 as a critical driver of cholangiocarcinoma growth and immune evasion, showing its inhibition enhances antitumor immunity and synergizes with immunotherapy.

PRMT5 as an Epigenetic Target for Group 3 (MYC-driven) Medulloblastoma

This study identifies PRMT5 as an epigenetic regulator of MYC transcription and oncogenic programs in Group 3 medulloblastoma, showing that its inhibition suppresses tumor growth and prolongs survival in mouse models.

PRMT5-Mediated Arginine Methylation of HSP90AA1 Drives Esophageal Squamous Cell Carcinoma Progression

This study identifies PRMT5-mediated arginine methylation of HSP90AA1 as a driver of ESCC progression and shows that targeting this axis has therapeutic potential.

Identification of a lineage-agnostic splicing signature caused by PRMT5 inhibition

This paper identifies a splicing signature caused by PRMT5 inhibition in MTAP-deleted cancers, showing histology-agnostic splicing changes and potential as a biomarker for PRMT5 inhibitor activity.

LC-MS profiling of prmt-1 and prmt-5 knockout C. elegans reveals PRMT-1 substrates and global proteome remodeling

The paper uses LC-MS proteomics to identify PRMT-1 substrates and quantify proteome changes in C. elegans prmt-1 and prmt-5 knockout mutants.

Cellular consequences, citrullination substrates, and antigenicity resulting from wild-type and targeted PAD4 on cell surfaces

This study identifies PAD4 substrates and their citrullination effects, showing PAD4 induces cell migration and generates citrullinated peptides that can trigger autoantibodies.

Characterization of Lysine Methylation During Neuronal Differentiation of LUHMES cells.

This study identifies changes in non-histone lysine methylation during neuronal differentiation of LUHMES cells using quantitative proteomics.

Secreted protein methyltransferase METTL9 catalyzes Nπ-histidine methylation of extracellular plasma proteins

The paper identifies METTL9 as the first secreted methyltransferase that catalyzes Nπ-histidine methylation of extracellular plasma proteins, establishing histidine methylation as the second extracellular post-translational modification.

The cytosolic PRMT5-CDK4 complex impairs cell cycle kinase signaling

The paper identifies PRMT5-CDK4 complex formation as a non-enzymatic regulator of cell cycle signaling, showing it modulates CDK4 interactions and mimics CDK4 inhibition.

Decoding isozyme-specific substrate recognition in protein arginine deiminases by proteome-wide citrullination mapping

The paper maps isozyme-specific substrate recognition of PAD1-4 by identifying citrullination sites across the proteome, revealing distinct sequence preferences and key residues determining substrate specificity.

Brain endothelial PRMT5-ANGPTL4 axis regulates cerebellar inhibitory synaptogenesis and motor coordination

This study identifies the endothelial PRMT5-ANGPTL4 axis as critical for cerebellar inhibitory synaptogenesis and motor coordination in mice.

PRMT5-mediated histone methylation regulates alternative splicing via MECP2-PTBP1 to promote EMT in breast cancer hypoxia

JMJD5 regulates metabolism by hydroxylating ISY1, and regulating the Arginine Methyltransferase PRMT6

This paper identifies JMJD5-ISY1-PRMT6 as a pathway regulating metabolism by hydroxylating ISY1 to inhibit PRMT6, showing its role in liver cancer and potential as a therapeutic target.

Increased activity of PRMT5-MEP50 complex improves survival of chromosomally unstable cancer cells by increasing tolerance to protein aggregation and proteotoxicity

The paper shows that increased PRMT5-MEP50 complex activity helps aneuploid cancer cells survive by reducing protein aggregation and proteotoxicity.

Oligomerization of PRMT1 Regulated RNA-Binding Protein Cascade Promotes Pancreatic Ductal Adenocarcinoma

This study identifies PRMT1 oligomerization as critical for its function in pancreatic ductal adenocarcinoma by revealing its structural basis and functional impact on RNA-binding proteins.

CARM1-mediated methylation controls interactions of ALIX with key partners important for cytokinesis

This study identifies CARM1-mediated methylation of ALIX as critical for its interactions with SH3-domain proteins during cytokinesis.

PRMT5 activity sustains histone production to maintain genome integrity

This study shows PRMT5 sustains histone transcription and protein synthesis during S phase, maintaining genome integrity by regulating histone H4 methylation.

The PRMT5-splicing axis is a critical oncogenic vulnerability that regulates detained intron splicing

The paper identifies PRMT5 inhibition as inducing detained introns and shows their role in cancer vulnerability through conserved gene regulation across species.

PRMT activity promotes global 3' UTR shortening in proliferating cells

This study shows PRMT activity regulates 3' UTR shortening in proliferating cells through alternative polyadenylation, impacting cancer and immune-related diseases.

Potent and Selective SETDB1 Covalent Negative Allosteric Modulator Reduces Methyltransferase Activity in Cells

The paper identifies UNC10013, a covalent ligand targeting SETDB1's 3TD domain, which reduces methyltransferase activity and shows selectivity in cells.

Therapeutic Potential of PRMT1 as a Critical Survival Dependency Target in Multiple Myeloma

This study identifies PRMT1 as a critical survival dependency in multiple myeloma cells, showing that its inhibition reduces cell survival and impairs tumor growth.

PRMT1-Mediated Metabolic Reprogramming Promotes Leukemogenesis

This study shows PRMT1 promotes leukemogenesis by enhancing glycolysis and reducing fatty acid oxidation in AMKL cells.

Structure of the SMYD2-PARP1 Complex Reveals Both Productive and Allosteric Modes of Peptide Binding

The paper presents crystal structures of SMYD2, revealing an allosteric binding site that binds peptides, proteins, and small molecules, influencing catalytic activity and substrate specificity.

SETD8 inhibition targets cancer cells with increased rates of ribosome biogenesis

This study identifies novel SETD8 inhibitors and shows their toxicity correlates with ribosome biogenesis regulators, suggesting a biomarker for targeted cancer therapy.

The Interplay of Acetylation and Ubiquitination Controls PRMT1 Homeostasis

The paper identifies acetylation at K228 as a regulator of PRMT1 degradation via FBXL17-mediated ubiquitination, independent of transcript levels.