Neurological Disease Mechanisms and Treatments

Oligodendrocyte stress response as a driver of vascular dementia

This study identifies oligodendrocyte stress response as a driver of vascular dementia by showing its role in myelin damage and cognitive impairments in mice and humans.

Inhibition of Soluble Epoxide Hydrolase Rescues Cognitive Deficits by Preserving Neurovascular Integrity and Attenuating Glial- and Neuropathology in Diabetic-Related Dementia

This study shows that inhibiting soluble epoxide hydrolase with TPPU improves cognitive function in diabetic-related dementia by enhancing cerebral blood flow and reducing neuroinflammation and gliosis.

Neuroprotective Effect of Combined Pomegranate and Candesartan Therapy Against Chronic Cerebral Ischemia in Rats.

This study evaluates the neuroprotective effects of candesartan and pomegranate in a rat model of chronic cerebral ischemia, finding that their combination improves cognitive function more than either alone.

Chronic Aerobic Exercise Alleviates Amyloid-induced Capillary Dysfunction

This study shows that aerobic exercise preserves capillary oxygenation and improves hyperemic responses in preclinical Alzheimer's mice, suggesting a capillary-focused mechanism for exercise's neurovascular benefits.

PCSK9 and High-Fat Diet Synergistically Induce Neurovascular Dysfunction and Neuroinflammation

This study shows that PCSK9 overexpression with high-fat diet in mice causes neurovascular dysfunction and cognitive deficits, including lipid-droplet accumulating microglia and vascular amyloid-beta deposition.

Global hypoperfusion leads to a mismatch in oxygen delivery and consumption in the cerebral watershed area

This study investigates how global hypoperfusion affects oxygen delivery and consumption in the cerebral watershed area compared to the MCA territory using in vivo imaging techniques in mice.

Hypertension-Induced Neurovascular and Cognitive Dysfunction at Single-Cell Resolution

This study uses scRNA-seq in a mouse hypertension model to identify early molecular changes in brain cells linked to neurovascular dysfunction and cognitive impairment.

An Inflammation Centered Perspective to the Mechanisms and Interactions Related to Vascular Cognitive Impairment

This study identifies key protein interactions and pathways involved in vascular cognitive impairment by analyzing protein-protein interaction networks and conformational changes.

Intrinsic diving reflex enhances cognitive performance by alleviating microvascular dysfunction in vascular cognitive impairment

This study investigates how the diving reflex alleviates microvascular dysfunction and improves cognitive performance in a rat model of vascular cognitive impairment.

Intercellular Signaling Pathways as Therapeutic Targets for Vascular Dementia Repair

This study identifies intercellular signaling pathways involved in vascular dementia repair and demonstrates therapeutic potential through drug intervention.

Impaired capillary-venous drainage contributes to gliosis and demyelination in white matter during aging

The paper shows that impaired capillary-venous drainage in aging mice leads to hypoperfusion, gliosis, and demyelination in deep white matter regions.

Understanding Molecular Links of Vascular Cognitive Impairment: Selective Interaction between Mutant APP, TP53, and MAPKs

The paper identifies novel protein interactions involving mutant APP, TP53, and MAPKs in vascular cognitive impairment using network analysis and molecular modeling.

Vascular and neural transcriptomics reveal stage-dependent pathways to inflammation and cognitive dysfunction in a rat model of hypertension

This study investigates stage-dependent molecular and cellular changes in a rat model of hypertension, revealing vascular and neural pathways linked to inflammation and cognitive dysfunction.

Gradual cerebral hypoperfusion in a knock-in mouse model of Alzheimer's disease triggers cortical network dysfunctions

This study shows that gradual cerebral hypoperfusion in AD mouse models causes cortical network dysfunctions and microgliosis, with distinct effects in wild-type and AD mice.

Neurovascular Function in a Novel Model of Experimental Atherosclerosis

This study shows that experimental atherosclerosis in mice leads to reduced cortical hemodynamics and neural activity, associated with neuroinflammation and neuronal loss.

Low oxygen post conditioning improves stroke-induced cognitive impairment

This study shows that low oxygen post conditioning reduces amyloid-beta levels and improves cognitive function in mice after stroke.