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First Plant sedaDNA assemblage from California reveals ecological stability throughout 10,000 years of human presence at Lake Elsinore

Angiosperms353 capture of Lake Elsinore sedimentary DNA recovers 50 land-plant orders across 24,000 years, with a fire-linked community shift preceding a persistent Holocene chaparral assemblage.

Temporally overlapping mechanisms diversify clonal B cell responses in vivo.

Single-cell RNA and BCR sequencing of infected mouse spleens shows class switching overlaps clonal expansion, GC-seeding clones also form plasmablasts, and SHM proceeds at constant rate.

Human vein-to-artery endothelial cell fate transition is driven by VEGF/ERK activation and PI3K inhibition

A stem cell-derived human vein-to-artery endothelial conversion model mirrors angiogenesis-derived embryonic arteries; VEGF plus PI3K inhibition alone yields 92% DLL4+CXCR4+ endothelium by 48 hours.

AlphaFold3 for Structure-guided Ligand Discovery

Retrospective and prospective benchmarks show AlphaFold3 co-folding memorizes training poses and achieves half the prospective hit rate of DOCK3 at 6,700-fold higher cost, but excels as a post-docking filter.

A global map for introgressed structural variation and selection in humans

Long-read phased assemblies from two Papuans plus 47 HPRC genomes map archaic introgressed structural variants, revealing 11 candidate archaic centromeres and 16 candidate adaptive SVs.

Population-scale detection of methylation outliers from long-read genome sequencing

METAFORA calls depth-aware, covariate-adjusted methylation outlier regions from PacBio and Nanopore long reads; in 551 rare-disease genomes, outliers tracked structural variants, repeat expansions, and imprinting defects.

OmicsPred as a centralised resource for genetic prediction of multi-omic traits

OmicsPred collects 3,339,469 genetic prediction models for transcript, protein and metabolite traits with harmonised metadata and MetaXcan/PGSC-Calculator files, plus multi-ancestry Million Veterans Program phenome-wide association results.

eQTM (expression quantitative trait methylation) Atlas: a comprehensive resource of over 11 million DNA methylation-gene expression associations through across 11 tissues and 4 diseases

eQTM Atlas, an R Shiny resource, curates over 11 million DNA methylation-gene expression associations from eight cohorts and 11 tissues to annotate EWAS CpGs beyond proximity.

The Meatball Matchup: Plant vs. Animal Proteins on Campus

Stanford diners (n = 116) rated soy and soy-wheat meatballs below beef-based ones on moistness, meatiness, fattiness and tastiness, yet perceived no hardness or chewiness gap despite instrumental differences.

Replaying germinal center evolution on a quantified affinity landscape

Across 119 monoclonal germinal centers, B cell affinity rises reliably despite divergent phylogenies. Selection is noisy but persistent; mutability limits exploration. A DMS-based landscape shows saturating fitness and survivorship biases.

MD simulations of Human Sigma1 Receptor Trimer Uncovers Cholesterol Dependent Stabilization and Ligand Specific Dynamics

Across 12 µs of all-atom simulations, cholesterol stabilizes the sigma-1 receptor trimer, while haloperidol, unlike (+)-pentazocine, engages β6-strand W136 to tighten interprotomer coupling.

Cell type-specific proximity labeling of organ secretomes reveals energy balance-dependent proteomic remodeling.

A Cre-dependent ER-targeted TurboID knock-in mouse enables cell type-specific secretory proteomics, mapping adipocyte and hepatocyte responses to fasting, LPS and obesity, with B cells profiled at baseline.

EcoKMER: One-stop shop for spatio-temporal metagenomic exploration using DataFed

An R-Shiny app built on DataFed lets researchers filter metagenomic sample metadata by location, date and environmental variables, then download only matching sequence files via Globus.

Inclusive Biology Curriculum Interventions Can Reduce High School Students' Bioessentialist Beliefs

Participating in two or more gender-and-sexual-diversity-inclusive high school biology activities significantly reduced students' binary, bioessentialist sex and gender beliefs and increased diversity-affirming attitudes through four to six months.

AreTomoLive: Automated reconstruction of comprehensively-corrected and denoised cryo-electron tomograms in real-time and at high throughput

AreTomo3 and DenoisET form an automated GPU pipeline that reconstructs cryo-electron tomograms with tile-based contrast transfer function correction, screens their quality, and denoises them during acquisition.

From time-course expression to gene regulation: direct linear ODE inference without finite-difference approximation

Fitting a linear ODE with an equilibrium term via its matrix-exponential solution, not finite differences, raises TF-network AUROC over competing methods on simulated and scRNA-seq data.

Zebrafish facility report on implementation of artificial plants as structural enrichment

Across six zebrafish lines over one year, artificial home-tank plants left sex ratio, fertility and microbial counts unchanged, while fish avoided plant areas.

Empagliflozin targets a renal neuro-epithelial-immune axis in heart failure

Empagliflozin lowered renal norepinephrine by about 50% in rats with heart failure, independent of intrarenal renin-angiotensin activity, and shifted kidney macrophages toward a reparative phenotype.

Heterogeneous endocrine cell composition defines human islet functional phenotypes

In 299 islet preparations from donors without diabetes, endocrine cell composition, not donor demographics, tracked insulin secretion, and δ cell percentage rose with type 2 diabetes genetic risk.

Galvanin (TMEM154) is an electric-field sensor for directed cell migration

A CRISPRi migration screen in neutrophil-like HL-60 cells identified Galvanin (TMEM154), a single-pass membrane protein whose negatively charged ectodomain electrophoreses anodally to steer cathodal electrotaxis.