A. Brown

Nutrient limitation mimics artemisinin tolerance in malaria

This study shows that nutrient limitation increases malaria parasite tolerance to the drug dihydroartemisinin, mimicking genetic resistance mechanisms.

Arf GTPase activates the WAVE Regulatory Complex through a novel binding site

This study identifies a novel Arf1 binding site on WRC that drives activation through a mechanism distinct from Rac1.

Structures reveal a key mechanism of WAVE Regulatory Complex activation by Rac1 GTPase

The paper reports WAVE Regulatory Complex structures bound to Rac1, revealing how Rac1 binding at the A site activates WRC to drive actin polymerization.

Phylogeny and Metadata Network Database for Epidemiologic Surveillance

The paper creates a graph database to integrate SARS-CoV-2 phylogenetic trees, metadata, and surveillance data for phylodynamic analysis.

Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine

This study shows a nanoparticle vaccine induces broad neutralizing antibodies against multiple SARS-CoV-2 variants and protects non-human primates and mice from viral challenges.

Extensive sequence divergence of non-coding regions between Aspergillus fumigatus, a major fungal pathogen of humans, and its relatives

The paper identifies extensive non-coding sequence divergence in A. fumigatus compared to related species, highlighting its potential role in virulence.

A Developmentally Prometastatic Niche to Hepatoblastoma in Neonatal Liver mediated by the Cxcl1/Cxcr2 Axis

This study identifies a neonatal liver niche that promotes hepatoblastoma metastasis via the Cxcl1/Cxcr2 axis, showing increased tumor aggressiveness and hypoxia in early postnatal models.

Heterogeneity in the transcriptional response of the human pathogen Aspergillus fumigatus to the antifungal agent caspofungin

This study investigates transcriptional heterogeneity in Aspergillus fumigatus strains responding to caspofungin, identifying a core response and variable response linked to secondary metabolite biosynthesis and iron homeostasis.

Endoplasmic Reticulum morphological regulation by RTN4/NOGO modulates neuronal regeneration by slowing luminal transport

The paper shows RTN4/NOGO regulates ER morphology, which modulates luminal transport and Ca2+ delivery, affecting axonogenesis in neurons.

Paradoxical Roles of Peritumoral Myofibroblasts in Intrahepatic Cholangiocarcinoma Growth and Metastasis

This study shows peritumoral myofibroblasts suppress iCCA growth but promote metastasis through Vcam1-dependent mechanisms.

Regulation of neurofilament length and transport by a dynamic cycle of polymer severing and annealing

The paper tracks neurofilament movement in axons, showing that length regulation via severing and annealing affects transport, with phosphorylation modulating these processes.

Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections

This paper identifies mechanisms of niclosamide action and resistance in Gram-negative bacteria and demonstrates synergistic combination therapies with efflux inhibitors and membrane permeabilizers.

Chromosome painting in cultivated banana and their wild relatives (Musa spp.) reveals differences in chromosome structure

The paper uses FISH with chromosome-arm specific oligo painting probes to analyze chromosome structure differences in banana species and cultivars, revealing translocations and aiding in understanding their genomic evolution.

Purification of recombinant SARS-CoV-2 spike, its receptor binding domain, and CR3022 mAb for serological assay

The paper describes methods for purifying SARS-CoV-2 spike protein, its receptor binding domain, and CR3022 mAb, and validates their use in serological assays.

Disentangling interactions among mercury, immunity, and infection in a Neotropical bat community

The paper examines how mercury contamination interacts with immunity and infection in Neotropical bats, finding that higher mercury levels are linked to lower infection odds in some species but not others.

Pex11 β knockdown decreases peroxisome abundance and reverses the inhibitory effect of palmitate on pancreatic beta-cell function.

This study shows that reducing Pex11β decreases peroxisomes and reverses palmitate's negative impact on beta-cell function.

Non-canonical open reading frames encode functional proteins essential for cancer cell survival

The paper identifies non-canonical open reading frames (ORFs) that encode functional proteins essential for cancer cell survival, with one example, GREP1, showing preferential essentiality in breast cancer.

Structure and activation mechanism of the BBSome membrane-protein trafficking complex

The paper reports cryo-EM structures of the BBSome in inactive and active states, revealing how ARL6 binding activates the complex and how disease mutations disrupt its function.

Ecological and evolutionary drivers of hemoplasma infection and bacterial genotype sharing in a Neotropical bat community

The paper examines hemoplasma infection prevalence and genetic diversity in Neotropical bats, finding high host specificity and phylogenetic constraints on bacterial sharing.

Targeted metagenomic sequencing enhances the identification of pathogens associated with acute infection.

Castanet, a targeted metagenomic sequencing method, improves pathogen detection in clinical samples by combining sensitivity with cost-effectiveness and broad organism coverage.

Applying Inter-rater Reliability to Improve Consistency in Classifying PhD Career Outcomes

This study improves the reliability of PhD career outcome classification by revising a taxonomy and guidance document based on inter-rater reliability testing.

Influential parameters for the analysis of intracellular parasite metabolomics

This study identifies normalization parameters that significantly affect differential abundance analysis in metabolomics of intracellular parasites, highlighting the impact of host contamination.