J. Wang

Antigenicity and infectivity characterization of SARS-CoV-2 BA.2.86

This study characterizes the antigenic properties and infectivity of the SARS-CoV-2 BA.2.86 variant, finding it evades immune responses but has reduced infectivity compared to previous variants.

Preclinical screen for protection efficacy of chlamydial antigens that are immunogenic in humans

The paper screens 140 chlamydial antigens in mice to find subunit vaccine candidates, finding none effective but identifying pathogenic antigens and showing viable organisms induce better immunity.

Altered DNA methylation underlies monocyte dysregulation and innate exhaustion memory in sepsis

The paper identifies DNA methylation changes in sepsis-induced monocyte dysregulation and shows these can be reversed with specific treatments.

Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455-456 synergistically enhances antibody evasion and ACE2 binding

This study shows that convergent evolution of SARS-CoV-2 XBB lineages at RBD positions 455-456 synergistically enhances antibody evasion and ACE2 binding through epistatic interactions.

Dectin-1 Stimulation Promotes a Distinct Inflammatory Signature in the Setting of HIV-infection and Aging

This study shows that HIV-positive older adults have a unique inflammatory response to Dectin-1 stimulation, marked by increased cytokines and immune activation.

Expansion Strategy-Driven Micron-Level Resolution Mass Spectrometry Imaging of Lipids in Mouse Brain Tissue

This paper introduces a method to enhance spatial resolution in lipid mass spectrometry imaging of mouse brain tissue by using a swellable polyelectrolyte gel, achieving subcellular-level visualization.

Protein Coronas on Functionalized Nanoparticles Enable Quantitative and Precise Large-Scale Deep Plasma Proteomics

This paper demonstrates that nanoparticle-based proteomics workflows enable accurate and scalable deep plasma proteomics with high precision and statistical power for biomarker discovery.

Metagenomic analysis of individual mosquitos reveals the ecology of insect viruses

The paper analyzes the virome of 2,438 individual mosquitoes across China to reveal viral diversity, geographic hotspots, and the impact of host phylogeny on viral composition.

Semantic redundancy-aware implicit neural compression for multidimensional biomedical image data

This paper introduces SINCS, a compression method for multidimensional biomedical images that improves efficiency and quality by leveraging semantic redundancy and saliency maps.

Chemokine receptor 5 signaling in PFC mediates stress susceptibility in female mice

This study shows that CCL5-CCR5 signaling in the prefrontal cortex of female mice contributes to stress susceptibility by altering microglia function and BBB integrity.

Distinct Microstructural Heterogeneities Underpin Specific Micromechanical Properties in Human ACL Femoral and Tibial Entheses

This study identifies distinct microstructural and biomolecular features in ACL femoral and tibial entheses that contribute to their specific mechanical properties.

New insights into functional divergence and adaptive evolution of uncultured bacteria in anammox community by complete genome-centric analysis

The paper uses long-read sequencing to obtain complete metagenome-assembled genomes of anammox bacteria, revealing functional divergence and adaptive evolution through horizontal gene transfer and mobile genetic elements.

Lymphotoxin-β Promotes Bone Colonization and Osteolytic Outgrowth of Indolent Bone Metastatic cells of Breast Cancer

This study identifies lymphotoxin-β as a key factor promoting bone colonization and osteolytic outgrowth of breast cancer metastatic cells.

Uncovering the lung cancer mechanisms through the chromosome structural ensemble characteristics

This study develops a chromosome dynamic structural model to analyze the structural ensemble characteristics of normal and lung cancer cells, revealing links between chromosome structure, epigenetics, and gene expression.

SMB controls decompartmentalization in Arabidopsis root cap cells to execute programmed cell death

The paper identifies SMB-controlled decompartmentalization events and ion fluxes in Arabidopsis root cap cells that execute programmed cell death.

Percutaneous Intramyocardial Septal Cryoablation: A Canine Model with 6 months Follow-up

This study establishes a canine model for echocardiography-guided percutaneous intramyocardial septal cryoablation and shows its safety and feasibility in reducing interventricular septum.

RFC1 AAGGG pentanucleotide repeats form parallel G-quadruplex: structural implications for aberrant molecular cascades in CANVAS

The paper identifies and structures the G-quadruplex formed by RFC1 AAGGG repeats, showing its role in replication stalling and transcription inhibition in CANVAS.

Large-scale lensless microscopy with fast acquisition and region-wise focusing

This paper develops a fast acquisition and region-wise focusing strategy for lensless microscopy, achieving high-resolution imaging of biological samples with reduced acquisition and reconstruction times.

CD4+ T cell senescence is associated with reduced reactogenicity in severe/critical COVID-19

The paper finds that higher levels of CD4+ T cell senescence in severe/critical COVID-19 patients correlate with reduced antibody responses and worse survival, especially in breakthrough infections.

The essential genome of Xanthomonas citri

This study identifies essential genes and genomic features of Xanthomonas citri using transposon mutagenesis, revealing insights into its genome organization and potential therapeutic targets.

Frequency-dependent selection of neoantigens fosters tumor immune escape and predicts immunotherapy response

This study introduces negative frequency-dependent selection (NFDS) in tumors, showing it leads to immune evasion and poor response to immunotherapy, supported by whole-exome sequencing data.

Characterization of N-glycosylation and its Functional Role in SIDT1-Mediated RNA Uptake

This study maps N-glycosylation sites in SIDT1 and SIDT2 and shows their role in RNA uptake, cell surface expression, and protein stability.

Conformational Properties of Polymers at Droplet Interfaces as Model Systems for Disordered Proteins

The paper uses polymer models to study conformational properties at droplet interfaces, finding compact conformations and segmental enrichment at the interface, which mirrors behavior in natural proteins.

Quantifying the large-scale chromosome structural dynamics during the mitosis-to-G1 phase transition of cell cycle

This study quantifies chromosome structural dynamics during the mitosis-to-G1 phase transition using a data-driven model and nonequilibrium landscape-switching model, revealing asynchronous structural changes and TAD dynamics.

Metabolic Nutrient Preferences of Vibrio mimicus: Leveraging Nucleotides and Oligopeptides from Yellow Catfish for Enhanced Infectivity

This study identifies host-specific metabolites that enhance Vibrio mimicus infectivity in yellow catfish by providing nutrients like deoxyguanosine.

Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

This study identifies that WDR5 WIN site inhibitors suppress ribosome protein gene transcription, induce nucleolar stress, and activate p53 in MLL-rearranged cancer cells, revealing a novel ribosome-directed anti-cancer mechanism.

Emotional state dynamics impacts temporal memory

This study investigates how emotional state changes affect memory of temporal order and duration, finding that negative events compress time while shifts to negative events dilate time.

Replication stress inducing ELF3 upregulation promotes BRCA1-deficient breast tumorigenesis in luminal progenitors

The paper identifies replication stress as a driver of BRCA1-deficient breast tumorigenesis in luminal progenitors, showing ELF3 upregulation promotes this process.

Bioinformatic and Experimental Characterization of the RBM15 RNA Binding Protein

This study characterizes RBM15's RNA binding mechanism through bioinformatics and experiments, showing it interacts with stem-loop RNA motifs via RRMs 2 and 3.

The super-pangenome of Populus unveil genomic facets for adaptation and diversification in widespread forest trees

The paper constructs a super-pangenome of 19 Populus species to explore genomic factors driving adaptation and diversification in forest trees.